PER2相关文献与解析，生知库 | 链接生命科学的每一步

The circadian clock component PER2 deficiency aggravates airway epithelial remodeling through Wnt/Î²-catenin signaling pathway.

生物钟成分 PER2 缺乏通过 Wnt/β-catenin 信号通路加剧气道上皮重塑。

期刊:Respiratory Research

影响因子:5

doi:10.1186/s12931-026-03522-8

Zhang Shuwen, Lin Jiangtao

Circadian regulators PER1 and PER2 regulate osteoclastogenesis by balancing competing activities of innate immunity genes

昼夜节律调节因子PER1和PER2通过平衡先天免疫基因的竞争活性来调节破骨细胞生成。

期刊:

影响因子:

doi:10.64898/2026.01.11.698889

Katoku-Kikyo, Nobuko; Vu, Elizabeth K; Mitchell, Samuel; Karkache, Ismael Y; Bradley, Elizabeth W; Kikyo, Nobuaki

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis.

抑郁症的外周机制：肠道上皮 Per2 基因表达紊乱导致昼夜节律紊乱的小鼠出现抑郁行为，其机制是通过肠道屏障损伤和微生物群失调。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202501818

Zhang Huiliang, Qin Xuan, Song Haiyue, Zhou Jieru, Wei Hui, Zhang Lun, Liu Yi, Wang Zhuoqun, Zhang Yiren, Lai Yiwen, Yang Jiayu, Hu Wenting, Chen Zhongshan, Zeng Ji, Jin Yu, Wang Xiaochuan, Liu Rong

KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC

KDM6A磷酸化抑制PER2，从而导致头颈部鳞状细胞癌（HNSCC）中糖酵解脆弱性。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08130-w

Chen, Jun; Ji, Yikang; Chen, Xin; Zhang, Mi; Zhang, Mei; Hu, Xin; Xu, Xing; Zhang, Yu; Zhang, Zhen; Pan, Xinhua; Yan, Ming; Zhang, Jianjun; Xu, Qin; Yang, Xi; Chen, Wantao; Wang, Xu

The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior

CREB 和 PER2 之间的相互作用介导了躁狂样行为和抑郁样行为之间的转变。

期刊:Neuropsychopharmacology

影响因子:7.1

doi:10.1038/s41386-025-02076-5

Wang, Xin-Ling; Ji, Yan-Bin; Li, Su-Xia; Serchov, Tsvetan

Promoter Frame Position Affects Strength and Nature of Circadian Oscillations in hPER2 Luciferase Reporters

启动子框架位置影响hPER2荧光素酶报告基因昼夜节律振荡的强度和性质

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms262110785

Kalyanaraman, Bhavna; Villafana, Gabrielle; Taylor, Stephanie R; Farkas, Michelle E

PER2

发表日期：2025

文献求助收藏

PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an in vitro model of hepatocellular carcinoma

在体外肝细胞癌模型中，PER2表达和细胞定位在肿瘤侵袭性和耐药性方面起着关键作用。

期刊:Cancer Drug Resistance

影响因子:4.6

doi:10.20517/cdr.2024.193.

Mariarosaria Negri ,Feliciana Amatrudo ,Donatella Paola Provvisiero ,Roberta Patalano ,Giovanna Trinchese ,Fabiano Cimmino ,Cristina de Angelis ,Chiara Simeoli ,Renata Simona Auriemma ,Maria Pina Mollica ,Annamaria Colao ,Rosario Pivonello ,Claudia Pivonello

[Retracted] The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor‑associated genes in human oral squamous cell carcinoma

【已撤稿】昼夜节律基因PER2通过调控人类口腔鳞状细胞癌中的肿瘤相关基因，在肿瘤抑制中发挥重要作用。

期刊:Oncology Reports

影响因子:3.9

doi:10.3892/or.2025.8888

Su, Xiaoli; Chen, Dan; Yang, Kai; Zhao, Qin; Zhao, Dan; Lv, Xiaoqiang; Ao, Yiran

Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock

PER2寡聚化是哺乳动物生物钟动态调控的一种方式

p75NTR Promotes Circadian-Driven Mineralization During Tooth Development via CK2/PER2 Pathway

p75NTR通过CK2/PER2通路促进牙齿发育过程中昼夜节律驱动的矿化作用

The circadian clock component PER2 deficiency aggravates airway epithelial remodeling through Wnt/Î²-catenin signaling pathway.

生物钟成分 PER2 缺乏通过 Wnt/β-catenin 信号通路加剧气道上皮重塑。

Circadian regulators PER1 and PER2 regulate osteoclastogenesis by balancing competing activities of innate immunity genes

昼夜节律调节因子PER1和PER2通过平衡先天免疫基因的竞争活性来调节破骨细胞生成。

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis.

抑郁症的外周机制：肠道上皮 Per2 基因表达紊乱导致昼夜节律紊乱的小鼠出现抑郁行为，其机制是通过肠道屏障损伤和微生物群失调。

KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC

KDM6A磷酸化抑制PER2，从而导致头颈部鳞状细胞癌（HNSCC）中糖酵解脆弱性。

The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior

CREB 和 PER2 之间的相互作用介导了躁狂样行为和抑郁样行为之间的转变。

Promoter Frame Position Affects Strength and Nature of Circadian Oscillations in hPER2 Luciferase Reporters

启动子框架位置影响hPER2荧光素酶报告基因昼夜节律振荡的强度和性质

PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an in vitro model of hepatocellular carcinoma

在体外肝细胞癌模型中，PER2表达和细胞定位在肿瘤侵袭性和耐药性方面起着关键作用。

[Retracted] The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor‑associated genes in human oral squamous cell carcinoma

【已撤稿】昼夜节律基因PER2通过调控人类口腔鳞状细胞癌中的肿瘤相关基因，在肿瘤抑制中发挥重要作用。