PFKFB3相关文献与解析，生知库 | 链接生命科学的每一步

KrÃ¼ppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis.

Krüppel 样因子 15 通过调节 PFKFB3/AKT 轴来改善小鼠酒精性肝损伤。

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01651-2

Chen Hao, Yang Lin, Li Xiao-Feng, Han Si-Yuan, Zhao Qi, Xiao Rong-Cheng, Ou Zi-Yao, Fang Ling, Du Yan

Vitamin D attenuates the progression of pulmonary fibrosis via inhibiting thymidine kinase 1/PFKFB3-driven glycolysis

维生素D通过抑制胸苷激酶1/PFKFB3驱动的糖酵解来减缓肺纤维化的进展

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-025-07298-1

Yang, Huanyu; Zhang, Li; Han, Mengjia; Zhu, Keye; Guo, Xianghan; Yang, Wenkang; Xu, Qi

Proteomic Identification of PFKFB3 and PFKFB4 Associated with Coenzyme Metabolism and Redox Imbalance in Dairy Cows with Clinical Mastitis

通过蛋白质组学鉴定与临床乳腺炎奶牛辅酶代谢和氧化还原失衡相关的PFKFB3和PFKFB4

期刊:Antioxidants

影响因子:6.6

doi:10.3390/antiox15020240

Yu, Xing; Zhang, Bohao; Gao, Yumeng; Yang, Zhen; Dong, Weitao; Zhang, Yong; Zhao, Xingxu; Zhang, Quanwei

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease.

糖酵解激活剂 PFKFB3 的选择性自噬降解有助于维持炎症性肠病中的肠道上皮屏障。

期刊:International Journal of Molecular Medicine

影响因子:5.8

doi:10.3892/ijmm.2025.5714

Pan Yiyang, Yang Feng, Wang Liucan, Yang Tianshu, Du Guangsheng, Xu Cong, Yang Hua, Yu Min, Xiao Weidong

Ginsenoside Re regulates PFKFB3-mediated glycolysis to inhibit endothelial cell migration to ameliorate atherosclerosis.

人参皂苷 Re 调节 PFKFB3 介导的糖酵解，抑制内皮细胞迁移，从而改善动脉粥样硬化。

期刊:Journal of Ginseng Research

影响因子:5.6

doi:10.1016/j.jgr.2025.11.012

Wang Zhihui, Mou Junyu, Han Wen, Liu Siyuan, Wang Min, Sun Guibo

Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-Î²1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming.

从辣木种子中分离出的氰苷通过驱动代谢重编程抑制PFKFB3/TGF-β1/smads通路，从而缓解糖尿病肾病。

期刊:Pharmaceutical Biology

影响因子:4.8

doi:10.1080/13880209.2025.2607563

Ge Chengyu, Shi Zhihua, He Jia, Feng Xu, Shang Kaiqi, Liao Xiaolin, Liu Yufeng, Jiang Yueping, Liu Shao

Inhibition of PFKFB3 in macrophages ameliorates intestinal inflammation by modulating gut microbiota in DSS-induced colitis.

抑制巨噬细胞中的 PFKFB3 可通过调节肠道菌群来缓解 DSS 诱导的结肠炎中的肠道炎症。

期刊:mSystems

影响因子:4.6

doi:10.1128/msystems.00632-25

Gao Jia-Hui, Li Li-Xiang, Li Wei-Jia, Wang Xia, Lyu Dong-Ping, Xie Xiao-Ran, Li Shi-Yang, Zuo Xiu-Li, Li Yan-Qing

Immunology/Inflammation

NAT10 promotes the glycolysis of retinoblastoma through ac4C modification of PFKFB3 mRNA.

NAT10 通过 PFKFB3 mRNA 的 ac4C 修饰促进视网膜母细胞瘤的糖酵解。

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-026-15546-w

Li Zhen, Xie Weiwei, Wang Layi, Wu Guohai

PFKFB3 exacerbates myocardial injury by accelerating CXCR4hi neutrophil mobilization after acute myocardial infarction

PFKFB3通过加速急性心肌梗死后CXCR4hi中性粒细胞的动员，加剧心肌损伤。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0333657

Xu, Yingjia; Xiao, Min; Zhu, Qin; Wang, Wutao; Wang, Danrui; Liu, Dadong; Yu, Zongying

Glucose Metabolic Enzyme PFKFB3 in Cardiopulmonary Vascular Health and Disease

葡萄糖代谢酶PFKFB3在心肺血管健康和疾病中的作用

KrÃ¼ppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis.

Krüppel 样因子 15 通过调节 PFKFB3/AKT 轴来改善小鼠酒精性肝损伤。

Vitamin D attenuates the progression of pulmonary fibrosis via inhibiting thymidine kinase 1/PFKFB3-driven glycolysis

维生素D通过抑制胸苷激酶1/PFKFB3驱动的糖酵解来减缓肺纤维化的进展

Proteomic Identification of PFKFB3 and PFKFB4 Associated with Coenzyme Metabolism and Redox Imbalance in Dairy Cows with Clinical Mastitis

通过蛋白质组学鉴定与临床乳腺炎奶牛辅酶代谢和氧化还原失衡相关的PFKFB3和PFKFB4

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease.

糖酵解激活剂 PFKFB3 的选择性自噬降解有助于维持炎症性肠病中的肠道上皮屏障。

Ginsenoside Re regulates PFKFB3-mediated glycolysis to inhibit endothelial cell migration to ameliorate atherosclerosis.

人参皂苷 Re 调节 PFKFB3 介导的糖酵解，抑制内皮细胞迁移，从而改善动脉粥样硬化。

Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-Î²1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming.

从辣木种子中分离出的氰苷通过驱动代谢重编程抑制PFKFB3/TGF-β1/smads通路，从而缓解糖尿病肾病。

Inhibition of PFKFB3 in macrophages ameliorates intestinal inflammation by modulating gut microbiota in DSS-induced colitis.

抑制巨噬细胞中的 PFKFB3 可通过调节肠道菌群来缓解 DSS 诱导的结肠炎中的肠道炎症。

NAT10 promotes the glycolysis of retinoblastoma through ac4C modification of PFKFB3 mRNA.

NAT10 通过 PFKFB3 mRNA 的 ac4C 修饰促进视网膜母细胞瘤的糖酵解。

PFKFB3 exacerbates myocardial injury by accelerating CXCR4hi neutrophil mobilization after acute myocardial infarction

PFKFB3通过加速急性心肌梗死后CXCR4hi中性粒细胞的动员，加剧心肌损伤。