日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

自噬及时调控PHGDH介导的丝氨酸代谢，以支持卵母细胞发育。

期刊:Autophagy
影响因子:14.3
doi:10.1080/15548627.2025.2552907
细胞生物学
代谢
发育与干细胞
信号转导
PHGDH
Autophagy
自噬
发表日期：2026
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A ESRP1/circPHGDH/miR-149/RAP1B positive feedback loop promotes the malignant behaviors and glycolysis of prostate cancer cell

ESRP1/circPHGDH/miR-149/RAP1B正反馈环路促进前列腺癌细胞的恶性行为和糖酵解。

期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-026-01646-x
Wang, Xiang; Yu, Limei; Qian, Xiaoling; Yu, Zhenfei
肿瘤
肿瘤免疫
PHGDH
细胞生物学
前列腺癌
发表日期：2026
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PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer

PHGDH 处于十字路口：代谢可塑性、转移悖论和癌症治疗探索

期刊:Journal of Biomedical Science
影响因子:12.1
doi:10.1186/s12929-025-01205-y
Hao, Liang; Li, Bai-Qiang; Lu, Shi-Yang; An, Zhong-Cai; Yin, Zheng-Yuan; Du, Zhen-Xian; Wang, Hua-Qin
肿瘤
肿瘤免疫
PHGDH
代谢
发表日期：2026
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PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury

星形胶质细胞中PHGDH依赖的丝氨酸代谢：脑缺血再灌注损伤中氧化应激和细胞焦亡的关键调节因子

期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2025.103954
Zhang, Jimeng; Luo, Yaowen; Xie, Changcai; Zhang, Min; Qin, Heyao; Zhou, Yuefei; Wu, Xiuquan; Hu, Chenchen; Hu, Feiming; Fei, Xiaowei; Zhang, Hongchen; Li, Juan; Fu, Yihao; Yuan, Yunchao; Yang, Shuya; Gao, Dakuan
胶质细胞
表观遗传
PHGDH
氧化应激
神经科学
代谢
焦亡
细胞生物学
毒理研究
发表日期：2026
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RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease

PHGDH的RNA结合活性驱动散发性阿尔茨海默病人脑类器官模型中β-淀粉样蛋白的产生

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2532234123
Chen, Junchen; Xu, Ming; Liu, Yuan; Hadi, Fatemeh; Xue, Shuanghong; Chien, Shu; Zhong, Sheng
3D/类器官
阿尔茨海默症
神经科学
PHGDH
发表日期：2026
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PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment

WNK1介导的PHGDH磷酸化可作为代谢脆弱性和对奥沙利铂治疗反应性的双重标志物。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2525213123
Fang, Shaobo; Jin, Guoguo; Yan, Mingyang; Song, Yanming; Zhao, Simin; Zhang, Chengjuan; Shao, Yang; Zhao, Kexin; Liu, Meng; Wang, Zhenwei; Jia, Xinyang; Guo, Qinxin; Guo, Manman; Wang, Meiyun; Guo, Zhiping; Dong, Zigang
PHGDH
信号转导
NK1
代谢
磷酸化
WNK1
发表日期：2026
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PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.

PHGDH 通过 TGF-β/Smad 信号通路调控细胞周期进程，从而驱动心肌细胞增殖和心肌再生。

期刊:Cell Proliferation
影响因子:5.6
doi:10.1111/cpr.70123
Zhang Han, Zhang Li, Feng Zehao, Li Xing, Qiu Zhaohui, Wang Xingyun, Qian Lingmei
细胞生物学
PHGDH
发表日期：2026
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PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification

PHGDH介导的丝氨酸生物合成代谢抑制血管钙化

期刊:Biology Direct
影响因子:4.9
doi:10.1186/s13062-026-00764-w
Tan, Liao; Liu, Jie; Shi, Ruizheng; Liu, Yubo
心血管
PHGDH
代谢
发表日期：2026
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PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia

PHGDH介导的丝氨酸合成通过维持脑缺血后GSH和NADPH水平来减少少突胶质细胞死亡

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2026.1735477
Zhang, Zhaolong; Tan, Jinhua; Lv, Mengfei; Duan, Zhongying; Wang, Congxiao; Gao, Mingchen; Cui, Yu; Feng, Yugong
细胞生物学
PHGDH
胶质细胞
神经科学
发表日期：2026
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Integrative analysis and functional validation identified palmitoylated PHGDH as a therapeutic target for colon adenocarcinoma

整合分析和功能验证确定棕榈酰化PHGDH是结肠腺癌的治疗靶点。

期刊:Cellular Oncology
影响因子:4.8
doi:10.1007/s13402-026-01207-4
Song, Yixian; Lin, Lingling; Liu, Dejian; Zhu, Mengqing; Wang, Pei; Li, Ke; Li, Aimin; Chen, Kequan; Ye, Zhanhui
肿瘤
肿瘤免疫
PHGDH
发表日期：2026
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