PKCα相关文献与解析，生知库 | 链接生命科学的每一步

Tadokoro, Tomonori; Li, Hui; Gan, Peiheng; Xu, Zhisheng; Tan, Wei; Alzhanov, Damir; Sánchez-Ortiz, Efraín; McAnally, John R; Guo, Lei; Xu, Lin; Ruan, Peifeng; Liu, Ning; Olson, Eric N

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PKC

PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2-PKCÎ± pathway in Sertoli cells.

PTBP1 通过促进支持细胞中 mTORC2-PKCα 通路的细胞骨架组织来支持小鼠精子发生。

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-026-09636-5

Ozawa Manabu, Taguchi Jumpei, Mori Hideto, Kikuchi Mio, Muratani Masafumi, Yamamoto Takuya, Yamada Yasuhiro, Yoshida Nobuaki, Ikawa Masahito

USP14 and UCHL5 synergistically deubiquitinate PKCα and translocate NF-κB to promote the progression of anaplastic thyroid cancer

USP14 和 UCHL5 协同作用，使 PKCα 去泛素化并转位 NF-κB，从而促进未分化型甲状腺癌的进展。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-07890-9

Zhang, Song; Han, Bing; Jiang, Bo; Chen, Mengyu; Mu, Deyang; Wang, Qi; Sun, Shu; Xu, Tong; Song, Feifeng; Ren, Xinxin; Pan, Zongfu; Huang, Ping; Ge, Minghua

CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

CD271通过PI3K/Akt和PKCα/ERK通路调控皮肤结构、分化和炎症。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08062-5

Quadri, Marika; Reggiani Bonetti, Luca; Pellegrini, Cristina; Mastrangelo, Mirco; Caporali, Andrea; Vaschieri, Cristina; Lotti, Roberta; Fargnoli, Maria Concetta; Pincelli, Carlo; Marconi, Alessandra; Palazzo, Elisabetta

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model

人类 iPSC 衍生的小胶质细胞在嵌合小鼠视网膜模型中的整合和功能

期刊:Journal of Neuroinflammation

影响因子:9.3

doi:10.1186/s12974-025-03393-8

Chun Tang #, Qi-Qi Zhou #, Xiu-Feng Huang #, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, Jia Qu, Jun Zhang, Mei-Ling Gao1

PKCα Phosphorylates FACI to Switch Its Function in Clathrin-mediated Endocytosis to a Presumed Role in Macropinocytosis in Intestinal and Hepatic Cells

PKCα 磷酸化 FACI，使其在网格蛋白介导的内吞作用中的功能转变为在肠道和肝脏细胞中巨胞饮作用中发挥假定作用。

期刊:Cellular and Molecular Gastroenterology and Hepatology

影响因子:7.4

doi:10.1016/j.jcmgh.2025.101551

Cheng, Yun; Kang, Xiao-Zhuo; Fung, Sin-Yee; Siu, Kam-Leung; Jin, Dong-Yan

Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCÎµ/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.

α-酮戊二酸通过抑制 PKCα/MAPK/P65 信号通路来减弱 LPS 诱导的炎症反应，并抑制库普弗细胞中的氧化应激。

期刊:Inflammation

影响因子:5

doi:10.1007/s10753-025-02308-2

Li Yanfei, Kuang Haoran, Fan Guoqiang, Yang Xiaojing

Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCÎ±-Induced Î²-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression.

非瑟酮抗黑色素生成作用的机制研究：PKCα诱导β-catenin降解、ERK/MITF抑制和直接酪氨酸酶抑制。

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms262311739

Ei Zin Zin, Racha Satapat, Zou Hongbin, Chanvorachote Pithi

TROP-2 Promotes Cell Proliferation via the AKT-Mediated PKCÎ± Pathway and Is a Novel Target for Antibody-Drug Conjugates in Penile Carcinoma.

TROP-2 通过 AKT 介导的 PKCα 通路促进细胞增殖，是阴茎癌抗体药物偶联物的新靶点。

期刊:Oncology Research

影响因子:4.1

doi:10.32604/or.2025.066184

Tang Yi, Situ Minyi, Wu Zhiming, Wang Yanjun, Deng Xinpei, Liu Zhicheng, Guo Shengjie, Zhou Qianghua, Yuan Gangjun, Tan Xingliang, Yao Kai

DADS Regulates EMT and Chemotherapy Resistance by Inhibiting RORÎ±/Î²-Catenin Signaling through PKCÎ±-Dependent Phosphorylation in Gastric Cancer.

DADS 通过 PKCα 依赖性磷酸化抑制 RORα/β-catenin 信号传导来调节胃癌中的 EMT 和化疗耐药性。

期刊:Oncology Research

影响因子:4.1

doi:10.32604/or.2025.068689

Zhang Yizhen, Li Juan, Liu Huanqing, Xia Hong, Su Jian, Liu Fang, Su Bo, Su Qi

Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure

利用 CRISPR-Cas9 碱基编辑技术消除 PKCα 磷酸化可挽救心力衰竭

PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2-PKCÎ± pathway in Sertoli cells.

PTBP1 通过促进支持细胞中 mTORC2-PKCα 通路的细胞骨架组织来支持小鼠精子发生。

USP14 and UCHL5 synergistically deubiquitinate PKCα and translocate NF-κB to promote the progression of anaplastic thyroid cancer

USP14 和 UCHL5 协同作用，使 PKCα 去泛素化并转位 NF-κB，从而促进未分化型甲状腺癌的进展。

CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways

CD271通过PI3K/Akt和PKCα/ERK通路调控皮肤结构、分化和炎症。

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model

人类 iPSC 衍生的小胶质细胞在嵌合小鼠视网膜模型中的整合和功能

PKCα Phosphorylates FACI to Switch Its Function in Clathrin-mediated Endocytosis to a Presumed Role in Macropinocytosis in Intestinal and Hepatic Cells

PKCα 磷酸化 FACI，使其在网格蛋白介导的内吞作用中的功能转变为在肠道和肝脏细胞中巨胞饮作用中发挥假定作用。

Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCÎµ/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.

α-酮戊二酸通过抑制 PKCα/MAPK/P65 信号通路来减弱 LPS 诱导的炎症反应，并抑制库普弗细胞中的氧化应激。

Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCÎ±-Induced Î²-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression.

非瑟酮抗黑色素生成作用的机制研究：PKCα诱导β-catenin降解、ERK/MITF抑制和直接酪氨酸酶抑制。

TROP-2 Promotes Cell Proliferation via the AKT-Mediated PKCÎ± Pathway and Is a Novel Target for Antibody-Drug Conjugates in Penile Carcinoma.

TROP-2 通过 AKT 介导的 PKCα 通路促进细胞增殖，是阴茎癌抗体药物偶联物的新靶点。

DADS Regulates EMT and Chemotherapy Resistance by Inhibiting RORÎ±/Î²-Catenin Signaling through PKCÎ±-Dependent Phosphorylation in Gastric Cancer.

DADS 通过 PKCα 依赖性磷酸化抑制 RORα/β-catenin 信号传导来调节胃癌中的 EMT 和化疗耐药性。