PLP1相关文献与解析，生知库 | 链接生命科学的每一步

A canine PLP1 missense variant differentiates oligodendrocyte maturation in connatal and classical Pelizaeus-Merzbacher disease.

犬类 PLP1 错义变异可区分先天性和经典型 Pelizaeus-Merzbacher 病中的少突胶质细胞成熟。

期刊:Proceedings of the National Academy of Sciences of the United States of America

Gutierrez-Quintana Rodrigo, Montague Paul, Rupp Angie, Leeb Tosso, Penderis Jacques, Byrne Niamh, Gonzalo-Nadal Veronica, August Ben, Mullin Margaret, Barrie Jennifer, Edgar Julia M, Duncan Ian D, McLaughlin Mark

Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases

血液来源的APLP1+细胞外囊泡是脑部疾病早期诊断的潜在生物标志物。

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.ado6894

Yuri Choi ，Jae Hyun Park ，Ala Jo ，Chul-Woo Lim ，Ji-Min Park ，Jin Woo Hwang ，Kang Soo Lee ，Young-Sang Kim ，Hakho Lee ，Jisook Moon

TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer

基于TMT的蛋白质组学分析鉴定出RPLP1是熊果酸抑制结直肠癌的关键蛋白靶点。

期刊:Discover Oncology

影响因子:2.9

doi:10.1007/s12672-025-03486-z

Zhu, Li-Min; Shi, Hai-Xia; Xu, Zhen-Ye; Deng, Hai-Bin

Clinical characteristics of the Ala21Val variant in the myelin proteolipid protein 1 (PLP1) gene associated with Pelizaeus-Merzbacher disease in a Brazilian male patient

巴西一名男性患者髓鞘蛋白脂蛋白1 (PLP1) 基因Ala21Val变异与佩利措伊斯-梅尔茨巴赫病相关的临床特征

期刊:Human Genome Variation

影响因子:1.3

doi:10.1038/s41439-024-00306-8

Manzke, Pedro; Brandão, Pedro Renato P; Balieiro, Talita; de Carvalho Bispo, Diógenes Diego; Osório, Maria Joana; Barra, Gustavo Barcelos

CRISPR/CasRx-Mediated Knockdown of Rab7B Restores Incomplete Cell Shape Induced by Pelizaeus-Merzbacher Disease-Associated PLP1 p.Ala243Val

利用 CRISPR/CasRx 介导的 Rab7B 基因敲低可恢复由 Pelizaeus-Merzbacher 病相关 PLP1 p.Ala243Val 突变引起的细胞形态不全

期刊:Neuroscience Insights

影响因子:2.9

doi:10.1177/26331055241276873

Nana Fukushima,Yuki Miyamoto,Junji Yamauchi

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

敲除 Rab9 可恢复 FBD-102b 细胞中由化学内质网应激诱导剂或 PMD 相关 PLP1 突变蛋白引起的形态分化缺陷

期刊:Pathophysiology

影响因子:2.7

doi:10.3390/pathophysiology31030032

Nana Fukushima ，Yuki Miyamoto ，Junji Yamauchi

Exploring the function and prognostic value of RPLP0, RPLP1 and RPLP2 expression in lung adenocarcinoma

探讨RPLP0、RPLP1和RPLP2表达在肺腺癌中的功能和预后价值

期刊:Journal of Molecular Histology

影响因子:2.2

doi:10.1007/s10735-024-10251-z

Xu, Chunyan; Lu, Zhimin; Hou, Guoxin; Zhu, Moran

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice

细胞毒性中枢神经系统相关T细胞通过靶向PLP1突变小鼠中功能紊乱的少突胶质细胞，驱动轴突退化。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2023.106698

Tassnim Abdelwahab ，David Stadler ，Konrad Knöpper ，Panagiota Arampatzi ，Antoine-Emmanuel Saliba ，Wolfgang Kastenmüller ，Rudolf Martini ，Janos Groh

PLP1 gene mutations cause spastic paraplegia type 2 in three families

PLP1基因突变导致三个家族出现痉挛性截瘫2型。

期刊:Annals of Clinical and Translational Neurology

影响因子:3.9

doi:10.1002/acn3.51722

Yao, Li; Zhu, Zeyu; Zhang, Chao; Tian, Wotu; Cao, Li

PLP1

发表日期：2023

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Spatially concentrated adenine base editors efficiently correct PLP1 mutations in oligodendrocytes.

空间集中的腺嘌呤碱基编辑器能有效纠正少突胶质细胞中的 PLP1 突变。

A canine PLP1 missense variant differentiates oligodendrocyte maturation in connatal and classical Pelizaeus-Merzbacher disease.

犬类 PLP1 错义变异可区分先天性和经典型 Pelizaeus-Merzbacher 病中的少突胶质细胞成熟。

Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases

血液来源的APLP1+细胞外囊泡是脑部疾病早期诊断的潜在生物标志物。

TMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid Inhibition of colorectal cancer

基于TMT的蛋白质组学分析鉴定出RPLP1是熊果酸抑制结直肠癌的关键蛋白靶点。

Clinical characteristics of the Ala21Val variant in the myelin proteolipid protein 1 (PLP1) gene associated with Pelizaeus-Merzbacher disease in a Brazilian male patient

巴西一名男性患者髓鞘蛋白脂蛋白1 (PLP1) 基因Ala21Val变异与佩利措伊斯-梅尔茨巴赫病相关的临床特征

CRISPR/CasRx-Mediated Knockdown of Rab7B Restores Incomplete Cell Shape Induced by Pelizaeus-Merzbacher Disease-Associated PLP1 p.Ala243Val

利用 CRISPR/CasRx 介导的 Rab7B 基因敲低可恢复由 Pelizaeus-Merzbacher 病相关 PLP1 p.Ala243Val 突变引起的细胞形态不全

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

敲除 Rab9 可恢复 FBD-102b 细胞中由化学内质网应激诱导剂或 PMD 相关 PLP1 突变蛋白引起的形态分化缺陷

Exploring the function and prognostic value of RPLP0, RPLP1 and RPLP2 expression in lung adenocarcinoma

探讨RPLP0、RPLP1和RPLP2表达在肺腺癌中的功能和预后价值

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice

细胞毒性中枢神经系统相关T细胞通过靶向PLP1突变小鼠中功能紊乱的少突胶质细胞，驱动轴突退化。

PLP1 gene mutations cause spastic paraplegia type 2 in three families

PLP1基因突变导致三个家族出现痉挛性截瘫2型。