日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains

UBR5 介导的异型泛素链控制 C9orf72 蛋白质质量

Julia Jülg, Dieter Edbauer, Christian Behrends

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

针对 RAN 蛋白的抗体疗法可挽救 C9orf72 小鼠模型中的 C9 ALS/FTD 表型

Lien Nguyen, Fabio Montrasio, Amrutha Pattamatta, Solaleh Khoramian Tusi, Olgert Bardhi, Kevin D Meyer, Lindsey Hayes, Katsuya Nakamura, Monica Banez-Coronel, Alyssa Coyne, Shu Guo, Lauren A Laboissonniere, Yuanzheng Gu, Saravanakumar Narayanan, Benjamin Smith, Roger M Nitsch, Mark W Kankel, Mia Rus

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation

黄芩苷通过保护谷氨酰胺合成酶免受 ROS 诱导的 20S 蛋白酶体降解来对抗谷氨酸兴奋毒性

Xianrui Song, Zixuan Gong, Kaili Liu, Junping Kou, Baolin Liu, Kang Liu

Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD

C9orf72 聚(Gly-Ala)的细胞间传播可触发 ALS/FTD 的关键特征

Bahram Khosravi, Kathrine D LaClair #, Henrick Riemenschneider #, Qihui Zhou #, Frédéric Frottin, Nikola Mareljic, Mareike Czuppa, Daniel Farny, Hannelore Hartmann, Meike Michaelsen, Thomas Arzberger, F Ulrich Hartl, Mark S Hipp, Dieter Edbauer

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

在小鼠中同源表达poly-GA(而非poly-PR)会引发选择性神经元丢失和干扰素反应,而这些反应在C9orf72 ALS中也存在。

Katherine D LaClair #,Qihui Zhou #,Meike Michaelsen,Benedikt Wefers,Monika S Brill,Aleksandar Janjic,Birgit Rathkolb,Daniel Farny,Mikolaj Cygan,Martin Hrabe de Angelis,Wolfgang Wurst,Manuela Neumann,Wolfgang Enard,Thomas Misgeld,Thomas Arzberger,Dieter Edbauer

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

UBQLN2 介导蛋白酶体清除自噬独立的蛋白质聚集体

Roland Hjerpe, John S Bett, Matthew J Keuss, Alexandra Solovyova, Thomas G McWilliams, Clare Johnson, Indrajit Sahu, Joby Varghese, Nicola Wood, Melanie Wightman, Georgina Osborne, Gillian P Bates, Michael H Glickman, Matthias Trost, Axel Knebel, Francesco Marchesi, Thimo Kurz