日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma

通过 miR-1304-5p 或法尼基转移酶抑制靶向 NRAS 可使 ALK 突变型神经母细胞瘤对 ALK 抑制剂敏感。

Perla Pucci ,Liam C Lee ,Miaojun Han ,Jamie D Matthews ,Leila Jahangiri ,Michaela Schlederer ,Eleanor Manners ,Annabel Sorby-Adams ,Joshua Kaggie ,Ricky M Trigg ,Christopher Steel ,Lucy Hare ,Emily R James ,Nina Prokoph ,Stephen P Ducray ,Olaf Merkel ,Firkret Rifatbegovic ,Ji Luo ,Sabine Taschner-Mandl ,Lukas Kenner ,G A Amos Burke ,Suzanne D Turner

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

SHP2 变构抑制剂的脱靶自噬抑制有助于其在 RAS 驱动的癌症中发挥抗肿瘤活性

Yiming Miao, Yunpeng Bai, Jinmin Miao, Allison A Murray, Jianping Lin, Jiajun Dong, Zihan Qu, Ruo-Yu Zhang, Quyen D Nguyen, Shaomeng Wang, Jingmei Yu, Frederick Nguele Meke, Zhong-Yin Zhang

The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1

催化抑制剂epacadostat可以影响IDO1的非酶功能

Eleonora Panfili, Giada Mondanelli, Ciriana Orabona, Marco Gargaro, Claudia Volpi, Maria Laura Belladonna, Sofia Rossini, Chiara Suvieri, Maria Teresa Pallotta

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

药物靶向 RAGE-NFκB 信号轴可通过抑制 SHP-2 酪氨酸磷酸酶功能来阻止糖尿病条件下的单核细胞活化

Marc Dorenkamp, Madina Nasiry, Dilvin Semo, Sybille Koch, Ivonne Löffler, Gunter Wolf, Holger Reinecke, Rinesh Godfrey

Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation

对 SHP2 磷酸酶结构域具有选择性的单体抑制剂及其作为量化 SHP2 变构调控的探针的用途

Fern Sha, Kohei Kurosawa, Eliezra Glasser, Gayatri Ketavarapu, Samara Albazzaz, Akiko Koide, Shohei Koide

Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

单细胞转录组学揭示变构抑制在结肠癌中 SHP2 介导的肿瘤免疫抑制

Jian Gao, Zhigui Wu, Mingxia Zhao, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu, Hongqi Chen, Dijun Chen, Yang Sun

BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia

BH3 类似物与尼洛替尼或普纳替尼联合使用是治疗急变期慢性粒细胞白血病的一种有前景的治疗策略

Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G Vignir Helgason, Helen Wheadon, Mhairi Copland

Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling

内皮细胞Shp2缺陷通过Notch信号通路控制巨噬细胞的替代激活,从而预防辐射引起的肺损伤。

Pan Liu ,Yiqing Li ,Mengyao Li ,Hui Zhou ,Huilun Zhang ,Yuefei Zhang ,Jiaqi Xu ,Yun Xu ,Jie Zhang ,Bing Xia ,Hongqiang Cheng ,Yuehai Ke ,Xue Zhang

Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2

Suchilactone 通过抑制 SHP2 来抑制急性髓系白血病的生长

Jingjing Wu, Yuan Deng, Xin Zhang, Jingjing Ma, Xinqi Zheng, Yue Chen

Shp2 suppresses fat accumulation in white adipose tissue by activating Wnt/β-catenin signaling following vertical sleeve gastrectomy in obese rats with type-2 diabetes

在患有 2 型糖尿病的肥胖大鼠接受垂直袖状胃切除术后,Shp2 通过激活 Wnt/β-catenin 信号抑制白色脂肪组织中的脂肪堆积

Xiaoyang Qi, Ziying Sun, Xugang Li, Yuwen Jiao, Shuai Chen, Peng Song, Zhifen Qian, Jun Qian, Xusheng Qiu, Liming Tang