日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2

利用 XRCC3-RAD51C-RAD51D-XRCC2 进行 RAD51 丝状体组装和末端封端的冷冻电镜可视化

Greenhough, Luke A; Galanti, Lorenzo; Liang, Chih-Chao; Boulton, Simon J; West, Stephen C

Rad51 determines pathway usage in post-replication repair.

Rad51 决定复制后修复过程中的通路使用情况。

Meyer Damon, Gore Steven K, Liu Jie, Ceballos Shannon J, Hung Shih-Hsun, Reginato Giordano, Cano-Linares Maria I, Maslowska Katarzyna H, Villafañez Florencia, Fasching Clare, Ede Christopher, Pagès Vincent, Prado Felix, Cejka Petr, Heyer Wolf-Dietrich

Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1.

F-box解旋酶1的SCF泛素连接酶复合物对叉反转和RAD51调控的结构基础。

Greer Briana H, Mendia-Garcia Javier, Mullins Elwood A, Peacock Emma M, Haigh Sander K, Schiltz Carl J, Aicart-Ramos Clara, Tsai Miaw-Sheue, Cortez David, Moreno-Herrero Fernando, Eichman Brandt F

The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments

人类 RAD52 复合物发生相分离,促进 RAD51 突触前丝的束状化和端对端连接。

Alshareedah, Ibraheem; Pangeni, Sushil; Dewan, Paul A Jr; Honda, Masayoshi; Liao, Ting-Wei; Spies, Maria; Ha, Taekjip

Impairment of oxidative metabolism compromises Rad51 recruitment and potentiates PARP inhibitor effectiveness in ovarian cancer.

氧化代谢受损会损害 Rad51 的募集,并增强 PARP 抑制剂在卵巢癌中的疗效。

Formenti Laura, Abramo Francesca, Dellavedova Giulia, Dematteis Valentina, Decio Alessandra, Grasselli Chiara, Fabbrizio Paola, Brunelli Laura, Giavazzi Raffaella, Ghilardi Carmen

Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity.

多组学分析和临床前模型实验表明,RAD51-IN-1 可增强安罗替尼的敏感性。

Meng Huangyang, Chang Qianjing, Zhang Yashuang, Ren Jingjing, Guo Hongyu, Yu Liang, Qian Cheng, Jiang Yi, Zhang Lin, Cheng Wenjun

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.

RAD51C-XRCC3 复合物调节 FANCM 介导的 R 环解析,以保障基因组完整性。

Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer

靶向 ANGPTL4/NRP1/ABL1/RAD51 轴可通过损害头颈癌中的 DNA 损伤修复来逆转顺铂耐药性。

Asiedu, Emmanuel B; Kumar, Ajay; Choi, Alexander; Luciano, Derek Osorio; Lo, Kevin; Sharma, Deepti; Ma, Tao; Rassool, Feyruz; Sodhi, Akrit; Montaner, Silvia

RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer.

RAD51 同源重组缺陷与早期乳腺癌的治疗反应和生存率相关。

Llop-Guevara Alba, Pellegrino Benedetta, Pimentel Isabel, Villacampa Guillermo, Solinas Cinzia, Torres-Esquius Sara, Campanini Nicoletta, Simonetti Sara, Tommasi Chiara, Serra Olga, Corianò Matilde, Boggiani Daniela, Michiara Maria, Minari Roberta, Bortesi Beatrice, Rapacchi Elena, Dieci Maria Vittoria, Lambertini Matteo, Zoppoli Gabriele, Schirone Alessio, Casarini Chiara, Cretella Elisabetta, Cortesi Laura, Silini Enrico Maria, Saura Cristina, Willard-Gallo Karen, Boisson Anais, Musolino Antonino, Serra Violeta, Balmaña Judith, Cruz Cristina

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51

Epacadostat 和 Olaparib 通过抑制 BRCA1 和 RAD51 的表达,协同抑制 BRCA 功能正常的三阴性乳腺癌的生长。

Huang, Lei; Yang, Ye; Duan, Dongxia; Dai, Li; Zhai, Bingxin; Qian, Bingjun