日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

支架蛋白GRASP/Tamalin直接与Dock180以及细胞黏附素结合,促进上皮细胞迁移中的GTP酶串扰。

Attar, Myriam A; Santy, Lorraine C

STRATEGIC-1: multiple-line, randomized, open-label GERCOR-PRODIGE-39 phase III trial in unresectable RAS/BRAF wild-type metastatic colorectal cancer

STRATEGIC-1:一项针对不可切除的 RAS/BRAF 野生型转移性结直肠癌的多线、随机、开放标签的 GERCOR-PRODIGE-39 III 期试验

Chibaudel, Benoist; Dourthe, Louis-Marie; André, Thierry; Henriques, Julie; Bourgeois, Vincent; Etienne, Pierre-Luc; Desramé, Jérôme; Carola, Elisabeth; Dupuis, Olivier; Baba-Hamed, Nabil; Auby, Dominique; Louvet, Christophe; Maillard, Emmanuel; Romano, Olivier; Tournigand, Christophe; Garcia-Larnicol, Marie-Line; Shacham-Shmueli, Einat; Bird, Brian Healey; Ghiringhelli, François; de Gramont, Aimery

Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations.

胰腺癌中垂直 RAS 通路抑制可驱动线粒体发生具有治疗意义的改变。

Upfront Modified FOLFOXIRI Plus Panitumumab for RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Final Results of the Phase III TRIPLETE Study

改良版 FOLFOXIRI 联合帕尼单抗一线治疗 RAS/BRAF 野生型转移性结直肠癌:III 期 TRIPLETE 研究的最终结果

Conca, Veronica; Rossini, Daniele; Antoniotti, Carlotta; Lonardi, Sara; Pietrantonio, Filippo; Moretto, Roberto; Antonuzzo, Lorenzo; Randon, Giovanni; Lavacchi, Daniele; Pozzo, Carmelo; Marmorino, Federica; Bergamo, Francesca; Tamburini, Emiliano; Passardi, Alessandro; Fazio, Roberta; Murgioni, Sabina; Borelli, Beatrice; Buonadonna, Angela; Germani, Marco Maria; Formica, Vincenzo; Carullo, Martina; Bordonaro, Roberto; Aprile, Giuseppe; Zaniboni, Alberto; Masi, Gianluca; Boni, Luca; Cremolini, Chiara

An oncogenic KRAS-driven secretome involving TNFα promotes niche preparation prior to pancreatic cancer onset.

致癌的 KRAS 驱动的分泌组(涉及 TNFα)促进胰腺癌发生前的微环境准备。

Allgöwer Chantal, Mulaw Medhanie A, Nagai James, Wiedenmann Sandra, Ringel Elena Anne, Ferrara Benedetta, Piemonti Lorenzo, Maulana Tengku Ibrahim, Ferreira Luisa T, Flinders Adam, Teufel Claudia, Reichardt Leon, Lopatta Paul B, Srinivasan Dharini, Lahusen Anton, Seufferlein Thomas, Gaisa Nadine Therese, Beck Annika, Lindenmayer Jessica, Melzer Michael K, Zimmer Eleni, Roger Elodie, Heller Sandra, Löhr J-Mathias, Liebau Stefan, Loskill Peter, Lin Yuan-Na, Camisa Paolo Riccardo, Jorgensen Claus, Crippa Stefano, Meier Matthias, Hohwieler Meike, Costa Ivan G, Breunig Markus, Kleger Alexander

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

转移性结直肠癌中 EMP1+ 到 LGR5+ 细胞状态的转化可绕过 KRASG12D 药物抑制。

Centonze Alessia, Roura Adrià-Jaume, Novillo-Font Meritxell, Giordano Cristina, Hernando-Momblona Xavier, Llanses Montserrat, Prats Paula, Sevillano Marta, Cabot Débora, Novell Mireia, Pabst Gabriel, Andersch Florian, Cañellas-Socias AdriÃ, Zhang Chong, Giakoumakis Nikolaos-Nikiforos, Sparks Hugh, Dunsby Chris, Colombelli Julien, Fernández-Barral Asunción, Sancho Elena, Stephan-Otto Attolini Camille, Muñoz Alberto, Barbachano Antonio, Palmer Héctor G, Martínez-Quintanilla Jordi, Zuber Johannes, Blaj Cristina, Quintana Elsa, Cortina Carme, Marti-Renom Marc A, Batlle Eduard

The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

GENEVA平台通过模拟肿瘤嵌合现象,揭示KRAS抑制剂反应的差异,并识别更有效的药物组合。

Yu, Johnny X; Suh, Jung Min; Popova, Katerina D; Garcia, Kristle; Joshi, Tanvi; Culbertson, Bruce; Spinelli, Jessica B; Subramanyam, Vishvak; Lou, Kevin; Charbonneau, Trey; Shokat, Kevan M; Weissman, Jonathan; Goodarzi, Hani

Multiselective RAS(ON) inhibition targets oncogenic RAS and overcomes RAS-mediated resistance to FLT3i and BCL2i in AML

多选择性 RAS(ON) 抑制剂靶向致癌 RAS,并克服急性髓系白血病 (AML) 中 RAS 介导的对 FLT3 抑制剂和 BCL2 抑制剂的耐药性。

Popescu, Bogdan; Jones, Matthew F; Piao, Madison; Tran, Elaine; Koh, Andrew; Lomeli, Isabelle; Peretz, Cheryl A C; Murad, Natalia; Abelson, Sydney; Morales, Carolina; Rivera, Jose M; Batingana, Alexa Rane; D'Souza, Jeevitha; Pikman, Yana; Cheng, Michael L; Logan, Aaron C; Huang, Benjamin J; Stieglitz, Elliot; Smith, Catherine C

IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response

IGH::FENDRR 和特定的 KRAS 突变定义了一种新型的 B 细胞急性淋巴细胞白血病 (B-ALL) 分子亚型,该亚型对化疗反应较差。

Bendig, Sonja; Hartmann, Alina M; Wessels, Wiebke; Beder, Thomas; Kim, Rathana; Passet, Marie; Gao, Qingsong; Wolgast, Nadine; Horns, Johanna M; Alves Santos, Leonardo; Iben, Katharina; Steffen, Fabio D; Cantoni, Loredana; Kehden, Britta; Chitadze, Guranda; Künstner, Axel; Busch, Hauke; Bornhauser, Beat; Bourquin, Jean-Pierre; Leguay, Thibaut Tl; Boissel, Nicolas; Gökbuget, Nicola; Iacobucci, Ilaria; Mullighan, Charles G; Clappier, Emmanuelle; Baldus, Claudia D; Brüggemann, Monika; Bastian, Lorenz

Geometry-driven immunomodulation in 3D-printed bioceramics: Negative curvature promotes macrophage M2 polarization via Ras-MAPK/HIF-1α signaling for vascularized osteogenesis.

几何形状驱动的 3D 打印生物陶瓷免疫调节:负曲率通过 Ras-MAPK/HIF-1α 信号传导促进巨噬细胞 M2 极化,从而促进血管化骨生成。

Lu Qiji, Kuang Yudi, Diao Jingjing, Zheng Jiaqian, Zhao Naru, Du Chang, Wang Yingjun