日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization.

突触囊泡糖蛋白 2A 抑制淀粉样蛋白形成,超越其突触作用:一种破坏 BACE1 结合和改变 APP 定位的新机制。

Wang Xiaoling, Zhang Qian, Zhang Xiaomin, Liu Jing, Zhang Jingjing, Liu Congcong, Cui Yuting, Song Qiao, Hou Yuli, Wang Yaqi, Cao Min, Wang Peichang

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

BACE1 通过酶促和非酶促作用调节睡眠-觉醒周期。

Heininger Hannah, Feng Xiao, Altunkaya Alp, Zheng Fang, Stockinger Florian, Wefers Benedikt, Müller Stephan A, Giesbertz Pieter, Tschirner Sarah K, Shqau Dorina, Adelsberger Helmuth, Ponomarenko Alexey, Fenzl Thomas, Alzheimer Christian, Lichtenthaler Stefan F, Huth Tobias

Increase in BACE1 Phosphorylation in the Rat Hippocampus and Phytosphingosine in Plasma After Chronic Administration of Scopolamine

长期服用东莨菪碱后,大鼠海马中BACE1磷酸化水平升高,血浆中植物鞘氨醇水平升高。

Velazquez Toledano, Jazziel; Guerrero González, Isaac; Pacheco-Yépez, Judith; Correa Basurto, José; Rosales Hernández, Martha Cecilia

Discontinued BACE1 Inhibitors in Phase II/III Clinical Trials and AM-6494 (Preclinical) Towards Alzheimer's Disease Therapy: Repurposing Through Network Pharmacology and Molecular Docking Approach

已停止 II/III 期临床试验的 BACE1 抑制剂和 AM-6494(临床前研究)在阿尔茨海默病治疗中的应用:通过网络药理学和分子对接方法进行药物再利用

Ugbaja, Samuel Chima; Kumalo, Hezekiel Matambo; Gqaleni, Nceba

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease

纳米木兰醇增强了木兰醇对链脲佐菌素诱导的阿尔茨海默病大鼠模型认知功能和BACE1相关生化变化的调节作用

Youssef, Basma; Ibrahim, Ehab A; Moselhy, Said S; ElShebiney, Shaimaa; ELabd, Walaa K

Identifying Potential BACE1 Inhibitors from the ChEMBL Database Using Machine Learning and Atomistic Simulation Approaches

利用机器学习和原子模拟方法从ChEMBL数据库中识别潜在的BACE1抑制剂

Dao, Quang Tung; Do, Thi Mai Dung; Thai, Quynh Mai; Tran, Phuong-Thao; Ngo, Son Tung; Nguyen, Trung Hai

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates

在非人灵长类动物中进行亚慢性给药时,Elenbecestat 和化合物 89 能有效抑制 BACE1,但对 BACE2 没有抑制作用。

Tschirner, Sarah K; Schmidt, Andree; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Müller, Stephan A; Horiguchi, Naotaka; Lichtenthaler, Stefan F

Recent advances towards BACE1 drug discovery and therapeutics design

BACE1药物发现和治疗设计方面的最新进展

Imran, Saim; Patel, Meera; Noroozifar, Meissam; Kerman, Kagan

Computational prioritization of multi-target inhibitors: explainable QSAR and docking-based discovery of dual AChE/BACE1 chemotypes

多靶点抑制剂的计算优先级排序:基于可解释的QSAR和分子对接的双重AChE/BACE1化学类型的发现

Bozkır, İsa; İbişoğlu, Merve Seda; Kayıkçıoğlu Bozkır, İlknur; Güler, Halil İbrahim

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

Ramalin通过靶向BACE1、HDAC6和MAPK通路改善阿尔茨海默病病理

Cho, Yongeun; Lee, Jeongmi; Choi, Bo Youn; Yun, Jin-Ho; Han, Sukmin; Baek, Seung Hyun; Park, Jinsu; Cho, Yoonsuk; Kim, Hark Kyun; Kim, Eunae; Palomera, Leon F; Lim, Jeein; Jeon, Yeji; Im, Jeonghyeong; Hong, Ju-Mi; Kim, Tai Kyoung; Kim, Sung Hyun; Yim, Joung Han; Jo, Dong-Gyu