RGS2相关文献与解析，生知库 | 链接生命科学的每一步

A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

KSHV RNA结合蛋白促进FOS抑制核酸酶AEN并反式激活RGS2以促进AKT磷酸化。

Majerciak, Vladimir; Alvarado-Hernandez, Beatriz; Ma, Yanping; Duduskar, Shivalee; Lobanov, Alexei; Cam, Maggie; Zheng, Zhi-Ming

信号转导

RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury

RGS2 是一种先天免疫检查点，可抑制 Gαq 介导的 IFNγ 生成和肺损伤。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2025.111878

Jagdish Chandra Joshi ，Bhagwati Joshi ，Cuiping Zhang ，Somenath Banerjee ，Vigneshwaran Vellingiri ，Vijay Avin Balaji Raghunathrao ，Mumtaz Anwar ，Tejas Pravin Rokade ，Lianghui Zhang ，Ruhul Amin ，Yuanlin Song ，Dolly Mehta

Systematic analysis of the RGS2 degron reveals characteristics of substrate recognition by the F-box protein FBXO44

对RGS2降解子进行系统分析，揭示了F-box蛋白FBXO44识别底物的特征

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2025.110757.

Harrison J McNabb ,Eugene Cho ,Mary Pitman ,Phillip S Rushton ,David Mobley ,Benita Sjögren

RGS20 reduces glioma stemness and temozolomide resistance by intrinsically inhibiting the WNT/β-catenin signaling pathway

RGS20通过内在抑制WNT/β-catenin信号通路来降低胶质瘤干细胞特性和替莫唑胺耐药性。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-30291-z

Xie, Yang; Li, Qi; Ma, Yecheng; Yang, Yongchang; Jin, Xingyu; Yi, Tailong; Ge, Xianglian; Xu, Xing; Yang, Xuejun; Huang, Qiang; Lu, Yalin; Li, Peng; Li, Wenliang; Wang, Xiaoguang; Piao, Yingzhe; Jin, Xun

Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay

利用基于细胞的NanoBit检测方法发现RGS2-FBXO44相互作用抑制剂

期刊:Molecular Pharmacology

影响因子:3

doi:10.1016/j.molpha.2025.100030

Aryal, Sadikshya; Wong, Cindy Shi Yee; McNabb, Harrison J; Junaid, Ahmad; Altman, Ryan A; Sjögren, Benita

Localization and quantification of placental HDAC9 and RGS2 during preeclampsia

先兆子痫期间胎盘 HDAC9 和 RGS2 的定位和定量

期刊:Physiological Genomics

影响因子:2.5

doi:10.1152/physiolgenomics.00156.2024.

Megan A Opichka,M Christine Livergood,Kirthikaa Balapattabi,McKenzie L Ritter,Curt D Sigmund,Anne E Kwitek,Justin L Grobe,Jennifer J McIntosh

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure

ZFP36 调节血管平滑肌收缩并维持血压

期刊:Advanced Science

影响因子:

doi:10.1002/advs.202408811

Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway

RGS20通过激活自噬和抑制PKA-Hippo信号通路促进非小细胞肺癌细胞增殖

期刊:Cancer Cell International

影响因子:6

doi:10.1186/s12935-024-03282-9

Ding, Xiaoyan; Li, Xiaoxia; Jiang, Yanxia; Li, Yujun; Li, Hong; Shang, Lipeng; Feng, Guilin; Zhang, Huhu; Xu, Ziyuan; Yang, Lina; Li, Bing; Zhao, Robert Chunhua

KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

KSHV促进致癌FOS抑制核酸酶AEN并反式激活RGS2以磷酸化AKT。

期刊:

影响因子:

doi:10.1101/2024.01.27.577582

Majerciak, Vladimir; Alvarado-Hernandez, Beatriz; Ma, Yanping; Duduskar, Shivalee; Lobanov, Alexei; Cam, Maggie; Zheng, Zhi-Ming

Correction: Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity

更正：靶向BATF2-RGS2轴可减少T细胞耗竭并恢复抗肿瘤免疫力

A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

KSHV RNA结合蛋白促进FOS抑制核酸酶AEN并反式激活RGS2以促进AKT磷酸化。

RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury

RGS2 是一种先天免疫检查点，可抑制 Gαq 介导的 IFNγ 生成和肺损伤。

Systematic analysis of the RGS2 degron reveals characteristics of substrate recognition by the F-box protein FBXO44

对RGS2降解子进行系统分析，揭示了F-box蛋白FBXO44识别底物的特征

RGS20 reduces glioma stemness and temozolomide resistance by intrinsically inhibiting the WNT/β-catenin signaling pathway

RGS20通过内在抑制WNT/β-catenin信号通路来降低胶质瘤干细胞特性和替莫唑胺耐药性。

Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay

利用基于细胞的NanoBit检测方法发现RGS2-FBXO44相互作用抑制剂

Localization and quantification of placental HDAC9 and RGS2 during preeclampsia

先兆子痫期间胎盘 HDAC9 和 RGS2 的定位和定量

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure

ZFP36 调节血管平滑肌收缩并维持血压

RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway

RGS20通过激活自噬和抑制PKA-Hippo信号通路促进非小细胞肺癌细胞增殖

KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

KSHV促进致癌FOS抑制核酸酶AEN并反式激活RGS2以磷酸化AKT。