BACE2相关文献与解析，生知库 | 链接生命科学的每一步

Matafora Vittoria, Elhagh Alice, Morelli Alessandra, Tronci Laura, Cattaneo Angela, Conti Camilla, Casagrande Francesca, Farris Francesco, Bachi Angela

细胞生物学

ACE

ACE2

BACE2

发表日期：2026

文献求助收藏

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates

在非人灵长类动物中进行亚慢性给药时，Elenbecestat 和化合物 89 能有效抑制 BACE1，但对 BACE2 没有抑制作用。

期刊:Proteomics

影响因子:3.9

doi:10.1002/pmic.70082

Tschirner, Sarah K; Schmidt, Andree; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Müller, Stephan A; Horiguchi, Naotaka; Lichtenthaler, Stefan F

BACE2 facilitates lung adenocarcinoma progression by enhancing mTORC1 signalling.

BACE2 通过增强 mTORC1 信号传导促进肺腺癌进展。

期刊:Translational Cancer Research

影响因子:1.7

doi:10.21037/tcr-2025-1670

You Zhixin, He Wei, Zhou Yanfei, Li Huijiao

An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells

肥胖致病基因 FTO 导致人类骨骼肌细胞加速发育、生长和胰岛素抵抗

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-53820-2

Lu Guang, Shilin Ma, Ziyue Yao, Dan Song, Yu Chen, Shuqing Liu, Peng Wang, Jiali Su, Yuefan Wang, Lanfang Luo, Ng Shyh-Chang

BACE2-Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia

BACE2诱导的异常淋巴网络加剧高磷血症动静脉瘘的局部炎症

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202509632

Chen, Kai; Guan, Ziyin; Jin, Hanwei; Aihemaiti, Muladili; Mou, Rong; Yu, Mengting; Hu, Yanhua; Jiang, Liujun; Wang, Xuliang; Yang, Hao; Chen, Ting; Lu, Yao; Zhang, Hongkun; Xu, Qingbo; Li, Weidong

BACE2

炎症

炎症/感染

Immunology/Inflammation

ACE2

发表日期：2025

文献求助收藏

The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage

人类内源性逆转录病毒包膜HEMO蛋白与BACE2相互作用：灵长类谱系中获得的新型伙伴关系

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2515527122

Béguin, Anthony; Chasseriaud, Marianne; Hollaender, Guillaume; Jacob, Yves; Mousseau, Guillaume; Heidmann, Thierry; Heidmann, Odile

ENO1-BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism.

ENO1-BACE2介导的LDLR裂解通过重塑胆固醇代谢促进肝癌进展。

期刊:Journal of Molecular Cell Biology

影响因子:5.9

doi:10.1093/jmcb/mjaf001

A chemokine-based prognostic model featuring CXCL8, ITGA5, BACE2, CCR7, CERS4, and MEI1 for cervical cancer.

以趋化因子为特征的宫颈癌预后模型，包括 CXCL8、ITGA5、BACE2、CCR7、CERS4 和 MEI1。

期刊:European Journal of Medical Research

影响因子:3.4

doi:10.1186/s40001-025-03688-9

Wang Liang, Wang Liying, Cao Yisen, Wang Qunhui, Sun Xiaoqi

Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer's Disease

关键协同作用：同时短暂使用整合应激反应抑制剂和BACE1和/或BACE2激活剂是治疗阿尔茨海默病的最佳策略

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms25189913

Volloch, Vladimir; Rits-Volloch, Sophia

Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer's Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (iAβ) by Its Targeted Degradation via Augmentation of Intra-iAβ-Cleaving Activities of BACE1 and/or BACE2

下一代治疗策略，用于治疗和预防阿尔茨海默病及衰老相关认知衰退：通过增强BACE1和/或BACE2的胞内Aβ（iAβ）切割活性，靶向降解iAβ，从而实现短暂、一生一次的胞内Aβ耗竭。

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms242417586

Volloch, Vladimir; Rits-Volloch, Sophia

BACE2 tunes lipid uptake through lipid transporters shedding supporting cancer cell proliferation.

BACE2 通过脂质转运蛋白的脱落来调节脂质吸收，从而支持癌细胞增殖。

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates

在非人灵长类动物中进行亚慢性给药时，Elenbecestat 和化合物 89 能有效抑制 BACE1，但对 BACE2 没有抑制作用。

BACE2 facilitates lung adenocarcinoma progression by enhancing mTORC1 signalling.

BACE2 通过增强 mTORC1 信号传导促进肺腺癌进展。

An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells

肥胖致病基因 FTO 导致人类骨骼肌细胞加速发育、生长和胰岛素抵抗

BACE2-Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia

BACE2诱导的异常淋巴网络加剧高磷血症动静脉瘘的局部炎症

The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage

人类内源性逆转录病毒包膜HEMO蛋白与BACE2相互作用：灵长类谱系中获得的新型伙伴关系

ENO1-BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism.

ENO1-BACE2介导的LDLR裂解通过重塑胆固醇代谢促进肝癌进展。

A chemokine-based prognostic model featuring CXCL8, ITGA5, BACE2, CCR7, CERS4, and MEI1 for cervical cancer.

以趋化因子为特征的宫颈癌预后模型，包括 CXCL8、ITGA5、BACE2、CCR7、CERS4 和 MEI1。

Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer's Disease

关键协同作用：同时短暂使用整合应激反应抑制剂和BACE1和/或BACE2激活剂是治疗阿尔茨海默病的最佳策略

下一代治疗策略，用于治疗和预防阿尔茨海默病及衰老相关认知衰退：通过增强BACE1和/或BACE2的胞内Aβ（iAβ）切割活性，靶向降解iAβ，从而实现短暂、一生一次的胞内Aβ耗竭。