日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity

NHEJ系统对DNA双链断裂的感知可稳定RORγt转录活性，并影响Th17在自身免疫中的致病性。

期刊:Cell Research
影响因子:25.9
doi:10.1038/s41422-025-01204-6
Chen, Guan-Yu; Zhu, Wen-Jie; Li, Zhuang; Hu, Yun-Wei; Luo, Xiao-Shuang; Mai, Zhi-Qing; Pan, Yuan; Shi, Yu-Xun; Li, Zuo-Yi; Huang, Jun; Yuan, Pei-Dong; Xiao, Zhi-Qiang; Chen, Qian; Xie, Yan-Yan; Huang, Hai-Xiang; Chen, Yu-Xi; Lu, Yao; Wang, Min-Zhen; Xia, Yi-Wen; Chen, Xiao-Qing; Kuang, Dong-Ming; Liang, Dan
RORγt
免疫/内分泌
发表日期：2026
文献求助 收藏

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development

IMU-935选择性地破坏RORγt-CBFβ相互作用可阻止RORγt依赖的Th17自身免疫，但不影响胸腺细胞发育。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI185942
Wu, Hongmin; Zhong, Xiancai; Ma, Ning; He, Zhiheng; Wang, Guanpeng; Lu, Geming; Yuan, Yate-Ching; Zhang, Wencan; Shi, Yun; Vaidehi, Nagarajan; Peelen, Evelyn; Wulff, Tanja; Gege, Christian; Kohlhof, Hella; Vitt, Daniel; Gwack, Yousang; Taniuchi, Ichiro; Xue, Hai-Hui; Sun, Zuoming
RORγt
细胞生物学
发育与干细胞
免疫/内分泌
发表日期：2026
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Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

更正：REV-ERB 通过 Bhlhe40-c-Maf 轴调控 RORγt+ 调节性 T 细胞的分化和功能。

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.2024146312152025C
Hu, Xianting; Liu, Zhi; Li, Yao; You, Yannan; Yue, Kaiye; Liang, Yuqiong; Loo, Chin-San; Yu, Jingting; Leblanc, Matthias; Wang, Dehui; Li, Huabin; Zheng, Ye
RORγt
信号转导
细胞生物学
T细胞
发表日期：2026
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REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

REV-ERB 通过 Bhlhe40-c-Maf 轴调控 RORγt+ 调节性 T 细胞的分化和功能。

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20241463
Hu, Xianting; Liu, Zhi; Li, Yao; You, Yannan; Yue, Kaiye; Liang, Yuqiong; Loo, Chin-San; Yu, Jingting; Leblanc, Matthias; Wang, Dehui; Li, Huabin; Zheng, Ye
RORγt
信号转导
细胞生物学
T细胞
发表日期：2026
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Dehydrocorydaline treatment suppresses Th17 differentiation via the mTOR-mediated STAT3-RORγt signaling in systemic lupus erythematosus

脱氢紫堇碱治疗通过 mTOR 介导的 STAT3-RORγt 信号通路抑制系统性红斑狼疮中的 Th17 分化

期刊:Molecular Medicine
影响因子:6.4
doi:10.1186/s10020-026-01435-2
Liu, Jiena; Zheng, Jingpeng; Sun, Yuanhong; Li, Weijie; Fu, Huafeng; Zeng, Jianteng; Wu, Haiqi; Meng, Yanfang; Liu, Yu; You, Daiting; Cui, Yuting; Tian, Zhongyu; Hu, Junhao; Tang, Chun; Xiao, Fan; Pan, Ting; Lu, Liwei; Dang, Yuanye; Dai, Xiaoyan; Tan, Hongmei; Ma, Kongyang
mTOR
JAK/STAT
信号转导
RORγt
STAT3
红斑狼疮
免疫/内分泌
发表日期：2026
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Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt

昼夜节律回路通过维持 RORγt 的表观遗传构型来控制第 3 组固有淋巴细胞的可塑性。

期刊:Nature Immunology
影响因子:27.6
doi:10.1038/s41590-025-02240-5
Bhattarai, Bishan; Antonova, Alina Ulezko; Fachi, Jose L; Hopkins, Leone S; McCullen, Matthew V D; Saini, Ankita; Oliveira, Sarah de; Beatty, Wandy L; Musiek, Erik S; Kuchroo, Vijay K; Lazar, Mitchell A; Oltz, Eugene M; Colonna, Marco
RORγt
细胞生物学
表观遗传
发表日期：2025
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Spontaneous Generation of an Endogenous RORγt Agonist

自发产生内源性RORγt激动剂

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c02724
Ma, Xiao Corey; Clardy, Jon
RORγt
发表日期：2025
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Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression-Associated Neuroinflammation

毛蕊花苷和阿魏酸通过双重靶向Nrf2和RORγt协同调节小胶质细胞极化，从而缓解抑郁症相关的神经炎症

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202503889
Guo, Dongjing; Mao, Qiancheng; Fang, Xinyu; Huang, Liuxuan; Tian, Haoquan; Yang, Wenguang; Zhou, Feiyue; Ma, Ke
胶质细胞
炎症
神经炎症
炎症/感染
RORγt
神经科学
细胞生物学
抑郁症
发表日期：2025
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Correction: K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

更正：Nedd4介导的K27连接的RORγt泛素化增强Th17介导的自身免疫

期刊:Journal of Biomedical Science
影响因子:12.1
doi:10.1186/s12929-025-01136-8
Zeng, Qiuming; Guo, Hui; Tang, Na; Renavikar, Pranav S; Karandikar, Nitin J; Lovett-Racke, Amy E; Racke, Michael K; Yan, Chengkai; Tang, Rong; Sinha, Sushmita; Ghosh, Krishnendu; Ryal, Jeremy P; Ouyang, Song; Chen, Min; Amari, Foued; Vincenzo, Coppola; Pope, R Marshall; Li, Yalan; Yang, Huan; Langdon, Wallace Y; Zhang, Jian
免疫/内分泌
RORγt
表观遗传
泛素化
发表日期：2025
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"What's in a name?" Clarifying the identity of RORγt+ antigen-presenting cells

“名称有何意义？” 阐明 RORγt+ 抗原呈递细胞的身份

期刊:Journal of Experimental Medicine
影响因子:10.6
doi:10.1084/jem.20250760
Ou, Feiya; Murphy, Kenneth M
RORγt
细胞生物学
发表日期：2025
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