日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS

一种新型的MTORC2-AKT-ROS轴在药物诱导的突变KRAS激活后,触发结直肠癌细胞的线粒体分裂和线粒体自噬相关死亡。

Kartini Iskandar ,Jonathan Foo ,Angeline Qiu Xia Liew ,Haiyuxin Zhu ,Deepika Raman ,Jayshree L Hirpara ,Yan Yi Leong ,Maria V Babak ,Anna A Kirsanova ,Anne-Sophie Armand ,Franck Oury ,Gregory Bellot ,Shazib Pervaiz

Correction: RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding

更正:RPTOR阻断通过劫持YY1结合干扰神经酰胺代谢,从而抑制非小细胞肺癌脑转移。

Lin, Ying; Wu, Yun; Zhang, Qiangzu; Tu, Xunwei; Chen, Sufang; Pan, Junfan; Xu, Nengluan; Lin, Ming; She, Peiwei; Niu, Gang; Chen, Yusheng; Li, Hongru

Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway

饮食蛋白质限制调节与 FGF21-ERK1/2 通路相关的骨骼肌纤维代谢特征

Shuo Li, Haopeng Zhong, Zirui Wang, Jun Chen, Zhouyin Huang, Tiande Zou, Jinming You

RPTOR Is an Alzheimer's Disease Susceptibility Gene Associated with the Risk Factors Body Mass Index and Infectious Encephalitis

RPTOR 是一种阿尔茨海默病易感基因,与体重指数和感染性脑炎等风险因素相关。

Lehrer, Steven; Rheinstein, Peter H

Cardiac-Specific Suppression of Valosin-Containing Protein Induces Progressive Heart Failure and Premature Mortality Correlating with Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1

心脏特异性抑制含缬氨酸蛋白会诱发进行性心力衰竭和过早死亡,与 mTOR 复合物 2 和蛋白磷酸酶 1 的时间失调相关

Xiaonan Sun, Xicong Tang, Hongyu Qiu

Development of Cellular Signaling Pathways by Bioceramic Heat Treatment (Sintering) in Osteoblast Cells

通过生物陶瓷热处理(烧结)在成骨细胞中发展细胞信号通路

Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin Hye Chung, Jinhong Wie

Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer

三维生长揭示癌症增殖途径对 5-脂氧合酶的微调

Tamara Göbel, Bjarne Goebel, Marius Hyprath, Ira Lamminger, Hannah Weisser, Carlo Angioni, Marius Mathes, Dominique Thomas, Astrid S Kahnt

N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

N7-甲基鸟苷tRNA修饰通过RPTOR/ULK1/自噬轴促进食管鳞状细胞癌的发生。

Hui Han #,Chunlong Yang #,Jieyi Ma #,Shuishen Zhang #,Siyi Zheng #,Rongsong Ling,Kaiyu Sun,Siyao Guo,Boxuan Huang,Yu Liang,Lu Wang,Shuang Chen,Zhaoyu Wang,Wei Wei,Ying Huang,Hao Peng,Yi-Zhou Jiang,Junho Choe,Shuibin Lin

Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia

PI3K/AKT/MTOR 信号通路的功能表征及其在 B 前体急性淋巴细胞白血病靶向治疗中的应用

Patricia K Grüninger, Franziska Uhl, Heike Herzog, Gaia Gentile, Marta Andrade-Martinez, Tobias Schmidt, Kyuho Han, David W Morgens, Michael C Bassik, Michael L Cleary, Oliver Gorka, Robert Zeiser, Olaf Groß, Jesús Duque-Afonso

Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary-Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice

前成骨细胞中 Rptor 的缺失揭示了哺乳动物雷帕霉素靶蛋白复合物 1 (mTORC1) 在饮食诱导的雌性小鼠骨量和葡萄糖稳态变化中的作用

Pawanrat Tangseefa,Sally K Martin,Agnieszka Arthur,Vasilios Panagopoulos,Amanda J Page,Gary A Wittert,Christopher G Proud,Stephen Fitter,Andrew C W Zannettino