日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.

将靶向 IRS2 的白蛋白结合 siRNA 治疗性递送至多种细胞类型可减少乳腺肿瘤的生长。

Tocheny Claire E, Buchwald Julianna E, Dahlke Christopher D, Fakih Hassan H, Morgan Jennifer S, Summers Ashley, Silva Christi A, Jackson Samuel O, Lee Ji-Sun, Card Michael-Anthony, Echeverria Dimas, Peterson Cornelia, Mercurio Arthur M, Khvorova Anastasia, Shaw Leslie M

Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.

整合应激反应的激活会导致线粒体脯氨酰-tRNA合成酶(PARS2)缺乏引起的发育迟缓和癫痫发作。

Xu Man, Liu Yuxin, Ma Runhua, Fan Wenlu, Duan Jingwei, Deng Huan, Ma Yanbin, Ge Wanzhong

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy

PCBP1 调控先天性心肌病中 AARS2 的选择性剪接

Lu, Yao Wei; Liang, Zhuomin; Dorr, Kerry; Ruiz, Samantha; Huang, Xiaoran; Fangnibo Hanvi, Denise; Juntilla, Sheri M; Beutner, Gisela; Lyu, Shuhan; Guo, Haipeng; Fernandes, Tiago; Espinoza-Lewis, Ramon A; Wang, Tingting; Li, Kathryn; Li, Xue; Bir Singh, Gurinder; Wang, Yi; Deng, Rui; Cowan, Douglas; Mably, John D; Pu, William T; Huang, Jessie; Porter, George A Jr; Conlon, Frank; Chen, Hong; Wang, Da-Zhi

A Randomized Phase II Study: CRS207/GVAX plus Anti-PD-1 and Anti-CTLA4 Recruits Mesothelin- and mKRAS-Specific T Cells into PDAC.

一项随机 II 期研究:CRS207/GVAX 联合抗 PD-1 和抗 CTLA4 可将间皮素和 mKRAS 特异性 T 细胞募集到 PDAC 中。

Bever Katherine M, Huff Amanda L, Danilova Ludmila, Wetzel Meredith, Tandurella Joseph A, Durham Jennifer N, Wang Tingchang, Lee Jae W, Coyne Erin M, Montagne Janelle M, Mitchell Jacob T, Hernandez Alexei G, Shin Sarah M, Anders Robert A, Wang Hao, Fertig Elana J, Jaffee Elizabeth M, Le Dung T, Ho Won Jin

Integrative pan-cancer analysis reveals AARS2 as a lactylation-associated biomarker and therapeutic target in colon adenocarcinoma

整合性泛癌分析揭示AARS2是结肠腺癌中与乳酸化相关的生物标志物和治疗靶点

Zou, Mingyang; Ding, Zixuan; Fu, Yifan; Yu, Wenxin; Song, Yulan; Wu, Xinyue; Pan, Yixin; Wu, Shaobo; Pan, Jiebin

Integrated spatial transcriptomics and single-cell RNA sequencing reveal Lars2-mediated spatiotemporal dynamics of myocardial remodeling in a mouse model of transverse aortic constriction.

整合空间转录组学和单细胞 RNA 测序揭示了 Lars2 介导的小鼠横向主动脉缩窄模型中心肌重塑的时空动态。

Ni Hanwen, Liang Feng, Huo Huanhuan, Feng Xuechao, He Ben

Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma

卡博替尼与DHRS2-KAT2A-H3K27ac轴驱动的铜凋亡诱导在透明细胞肾细胞癌中具有协同抗癌作用

Cao, Yilong; Xu, Chao; Zhang, Bowei; Qu, Changbao; Liu, Yuepeng; Shi, Bei; Li, Xiaoling; Li, Jiehan; Zhang, Zeyuan; Dai, Shengtao; Sun, Qingyun; Wang, Yaxuan; Gu, Junfei

Comparative genomics revealed the gene evolution and functional divergence of TaMRS2/CorA/NIPA magnesium transporter families in wheat (Triticum aestivum L.)

比较基因组学揭示了小麦(Triticum aestivum L.)中TaMRS2/CorA/NIPA镁转运蛋白家族的基因进化和功能分化。

Hao, Xiang-Yang; Zhang, Yu; Zhang, Jian-Zhou; Dong, Hai-Bin; Peng, Chao-Jun; Du, Xi-Jun; Wang, Chun-Ping; Fu, Yi-Han; Qi, Xue-Li

B-STARS2: Early contralesional continuous theta burst stimulation (cTBS) to promote upper limb recovery after stroke - Rationale and design of a phase-3 multicentre, randomised, sham-controlled, clinical trial

B-STARS2:早期对侧持续θ节律刺激(cTBS)促进卒中后上肢功能恢复——一项3期多中心、随机、假刺激对照临床试验的原理和设计

Vink, Jord J T; Verhoeff, Tessa A; Otte, Willem M; van der Meulen, Miriam P; van der Worp, H Bart; Visser-Meily, Johanna M A; Dijkhuizen, Rick M

Rougan Tongluo Decoction Initiates Neuroprotection Against Cerebral Ischemia by Activating the Endogenous SLC6A8-Creatine-EARS2 Mitochondrial Pathway.

柔肝通络汤通过激活内源性SLC6A8-肌酸-EARS2线粒体通路启动对脑缺血的神经保护作用。

Ou Changze, Bai Zheng-Ping, Hu Guo-Heng, Chen Binbin, Wu Da-Hua, Long Hua-Jun