日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment.

树突状细胞中血栓素受体的激活通过抑制 S100a8/a9 介导的中性粒细胞募集来减轻脓毒症。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-026-02592-w
细胞生物学
毒理研究
树突状细胞
粒细胞
S100A8
中性粒细胞
发表日期：2026
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Plasma proteomics identifies S100A8/A9 as a novel biomarker and therapeutic target for fulminant myocarditis

血浆蛋白质组学鉴定出S100A8/A9是暴发性心肌炎的新型生物标志物和治疗靶点

期刊:Journal of Advanced Research
影响因子:13
doi:10.1016/j.jare.2025.06.005
He, Wu; Wu, Junfang; Wang, Dongxue; Chen, Wendong; Yan, Yongcui; He, Qiongyao; Li, Chenze; Yang, Qianying; Huang, Chuanxi; Wen, Zheng; Chen, Chen; He, Fuchu; Tang, Liujun; Wang, Dao Wen
心肌炎
S100A8
心血管
发表日期：2026
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Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.

睡眠不足会损害卵泡发育，这是由于 S100A8/A9 驱动的巨噬细胞 M1 极化介导的颗粒细胞焦亡所致。

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.ady4767
Fang Qunying, Luo Lei, Jin Rentao, Wang Yanshi, Wang Jiawei, Jin Qi, Meng Ye, Shi Baolu, Qiao Zonghui, Li Fangfang, Chen Min, Chen Shengyuan, Xu Bo, Bao Jianqiang, Han Hui, Wu Limin
巨噬细胞
发育与干细胞
S100A8
表观遗传
巨噬细胞
粒细胞
焦亡
细胞生物学
免疫/内分泌
发表日期：2026
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CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming

CEBPB高表达的休眠肿瘤细胞通过S100A8调控的肿瘤相关巨噬细胞重编程驱动免疫逃逸

期刊:Theranostics
影响因子:12.4
doi:10.7150/thno.124789
Jin Bai,Huilan Su,Shunxi Wang,Yang Dong,Yong Gao
细胞生物学
肿瘤
信号转导
免疫/内分泌
巨噬细胞
肿瘤细胞
EBP
S100A8
CEBPB
巨噬细胞
发表日期：2026
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Single-cell and spatial transcriptomics reveal that the CXCL12-CXCR4 axis drives the immune-desert phenotype in small cell lung cancer by recruiting immunosuppressive CXCR4(+) neutrophils and S100A8(+) monocytes

单细胞和空间转录组学揭示，CXCL12-CXCR4轴通过募集免疫抑制性CXCR4(+)中性粒细胞和S100A8(+)单核细胞，驱动小细胞肺癌的免疫沙漠表型。

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2025-013867
Zeng, Peng; Li, Hai-Feng; Shu, Wen-Bin; Zhang, Jing; Zhao, Tian-Cheng; Hu, Jun-Wen; Wang, Jun-Fu; Wang, Cheng; Lu, Qing-Yun; Yang, Jia-Hui; An, Yan-Li; Chen, Rong
CXCR4
单核细胞
单细胞
肺癌
免疫/内分泌
CXCL12
S100A8
中性粒细胞
肿瘤
CXCL1
细胞生物学
肿瘤免疫
粒细胞
发表日期：2026
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The S100A8/A9–NETosis feedback loop in sepsis: potential mechanisms, immune crosstalk, and therapeutic targeting

脓毒症中S100A8/A9-NETosis反馈环路：潜在机制、免疫串扰和治疗靶点

期刊:BMC Medicine
影响因子:8.3
doi:10.1186/s12916-026-04784-1
Ai, Sizhi; Wu, Qiqi; Nie, Yu; Ou, Yiliang; He, Yu; Li, Puiyin; Ai, Qi Yong H; Feng, Hongliang; Liu, Yaping; Luo, Tong; Zhang, Jihui; Liang, Yannis Yan; Zhao, Runzhen; Xi, Nan Miles; Gabby, Lea; Gilbert, Emily R; Vanarsa, Kamala; Qiao, Mark; Zhang, Dee; Zhang, Jiwang; Mohan, Chandra; Judson, Marc A; Koth, Laura L; Ji, Hong-Long; Chen, Sini; Lin, Jingying; Huang, Jiahao; Deng, Liehua; Zhang, Yuanli
炎症/感染
败血症
免疫/内分泌
S100A8
NETosis
发表日期：2026
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Circulating S100A8/A9 drives faster platelet COX-1 recovery via MRP4, impairing the duration of aspirin response

循环中的S100A8/A9通过MRP4加速血小板COX-1的恢复，从而缩短阿司匹林疗效的持续时间。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2025017653
Liani, Rossella; Simeone, Paola Giustina; Alfonsetti, Margherita; Lattanzio, Stefano; Ricci, Alessia; Frezza, Maurizio; Ciotti, Sonia; Luongo, Myriam; Cipollone, Francesco; Pulcinelli, Fabio; Santilli, Francesca
血小板
MRP4
S100A8
发表日期：2026
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S100A8/A9 inhibition reduces splenic myelopoiesis and improves outcomes after stroke.

S100A8/A9 抑制可减少脾脏髓系造血，并改善中风后的预后。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2026.1768647
Kim Hyun Ah, Al-Sharea Annas, Chu Hannah X, Tang Sung-Chun, Rupasinghe Samoda A, Zhang Shenpeng R, Nagareddy Prabhakara R, Drummond Grant R, Arumugam Thiruma V, Murphy Andrew J, Sobey Christopher G, Lee Man K S
中风
S100A8
发表日期：2026
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Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia

哈洛夫吉酮通过调节 p-eIF2α-S100A8/A9-钙信号通路、抑制整体蛋白质合成以及逆转急性髓系白血病中伊达比星的耐药性，发挥广谱细胞毒性作用。

期刊:Chinese Medicine
影响因子:5.7
doi:10.1186/s13020-025-01278-9
Shi, Liuzhi; Zhao, Min; Meng, Chen; Li, Min; Yu, Xuanyu; Zhang, Shixin; Yu, Shirui; Chen, Xinyao; Zhou, Bin; Xing, Chongyun; Jia, Jinjun; Zhou, Jingying; Gao, Shenmeng
S100A8
信号转导
白血病
细胞生物学
毒理研究
发表日期：2026
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A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis

S100A8/9 与大疱性类天疱疮和特应性皮炎中的瘙痒敏感性相关的神经免疫轴

期刊:Veterinary Quarterly
影响因子:5.2
doi:10.1080/01652176.2025.2564447
Kim, Keon; Je, Chang-Yun; Seo, In Su; Do, Yoon Jung; Ro, Woong-Bin; Lee, Chang-Min; Lawson, Katy; Nho, Yeseul; Stewart, Ryan; Wu, Shuang; Cole, Emily F; Herrera, Daniel; Chisolm, Sarah; Feldman, Ron; Han, Liang
免疫/内分泌
S100A8
发表日期：2026
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