日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder

BCAT1基因的双等位基因变异会损害线粒体功能,并与一种候选神经代谢疾病相关。

Brianna L DiSanza,Giulia S Porcari,Livia Sertori Finoti,Leonardo Ramos-Rodriguez,Devin M Burris,Justin A McDonough,Gang Ning,Grace Fagan,Guy T Helman,Erin Weiss,Ryan J Taft,Amy Pizzino,Matthew T Whitehead,Amy Waldman,Cas Simons,Xilma Ortiz-Gonzalez,William C Skarnes,Adeline Vanderver,Elizabeth J Bhoj,Rebecca C Ahrens-Nicklas

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9

多组学分析揭示了BCAT1在B细胞受体和TLR9激活mTOR中的关键作用

Guo, Rui; Sun, Yizhe; Lim, Matthew Y; Shah, Hardik; Paulo, Joao A; Ahmed, Rahaman A; Li, Weixing; Zhang, Yuchen; Yang, Haopeng; Wang, Liang Wei; Strebinger, Daniel; Smith, Nicholas A; Li, Meng; Leong, Merrin Man Long; Lutchenkov, Michael; Liang, Jin Hua; Li, Zhixuan; Wang, Yin; Puri, Rishi; Melnick, Ari; Green, Michael R; Asara, John M; Papathanassiu, Adonia E; Wesemann, Duane R; Gygi, Steven P; Mootha, Vamsi K; Gewurz, Benjamin E

Correction: Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia

更正:BCAT1 异常表达增强 MTOR 活性并加速慢性淋巴细胞白血病的疾病进展

Shao, Qiangqiang; Wykretowicz, Jedrzej; Hu, Nan; Bedi, Karan; Rizk, Mohamed; Malek, Isabella A; Kumar, Surinder; Lombard, David B; Shedden, Kerby; Scott, David; Malek, Sami N

Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia

BCAT1 异常表达增强 mTOR 活性并加速慢性淋巴细胞白血病的疾病进展

Shao, Qiangqiang; Wykretowicz, Jedrzej; Hu, Nan; Bedi, Karan; Rizk, Mohamed; Malek, Isabella A; Kumar, Surinder; Lombard, David B; Shedden, Kerby; Scott, David; Malek, Sami N

Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells.

靶向 BCAT1 介导的 BCAA 代谢的小分子抑制 SHOC2-RAS-ERK 的激活,从而诱导三阴性乳腺癌细胞凋亡。

Huang Ling, Li Guanjun, Zhang Ying, Zhuge Ruishen, Qin Shijie, Qian Jinjun, Chen Ruixing, Kwan Wong Yin, Tang Huan, Wang Peili, Xiao Wei, Wang Jigang

BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy

BCAT1激活重编程支链氨基酸代谢,并通过表观遗传学途径促进糖尿病视网膜病变中的炎症反应。

Jingyi Wang,Zihan Yin,Jingxiao Yang,Sijun Sun,Xiaofang Tang,Shengjie Zhang,Yi-Ping Wang,Haiyan Wang

BCAT1 contributes to the development of TKI-resistant CML

BCAT1 参与了 TKI 耐药性 CML 的发展。

Jiang, Yu; Zhang, Difan; He, Xiaoxiao; Chen, Chiqi; Xie, Li; Liu, Ligen; Yu, Zhuo; Zhang, Yaping; Zheng, Junke; Huang, Dan

Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors

含桥联双环骨架的γ-氨基丁酸(GABA)衍生物作为BCAT1抑制剂的设计、合成及生物活性研究

Luo, Wen; Pan, Zilu; Zhu, Xinyuan; Li, Yan; Li, Yong; Zhang, Yudi; Pan, Jiamin; Ding, Jian; Xie, Hua; Zhao, Guilong

The ACSS2-PPARD-BCAT1 axis synchronously regulates branched-chain amino acid metabolism and development in pancreatic cancer

ACSS2-PPARD-BCAT1轴同步调控胰腺癌中支链氨基酸的代谢和发展

Chen, Haidi; Ye, Zeng; Liu, Lijun; Xu, Wenyan; Shi, Yihua; Ji, Shunrong; Xu, Xiaowu; Yu, Xianjun; Hou, Sen; Qin, Yi; Zhou, Chenjie

A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy

一种新型BCAT1抑制剂布法林可增强胰腺癌细胞对化疗的敏感性。

Zhang, Wei; Fan, Yibao; Ashrafizadeh, Milad; Shi, Dan; Sethi, Gautam; Ertas, Yavuz Nuri; Abd El-Aty, A M; Zhang, Xianbin; Chen, Si; Gong, Peng