日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism

IDH3A 缺乏会损害适应性产热,并通过 BCKDHA 依赖性 BCAA 分解代谢受损加剧肥胖引起的代谢功能障碍。

Lu, Xuhong; Bai, Ningning; Lyu, Jialu; Sun, Jingjing; Su, Yingying; Ye, Yafen; Hu, Tingting; Liu, Tianwen; Li, Wenfei; Li, Xiaoya; Ma, Xiaojing; Yang, Ying; Bao, Yuqian

Targeting the BCKDK/BCLAF1/MYC/HK2 axis to alter aerobic glycolysis and overcome Trametinib resistance in lung cancer

靶向 BCKDK/BCLAF1/MYC/HK2 轴以改变有氧糖酵解并克服肺癌中的曲美替尼耐药性

Wu, Hao; Yang, Jiajia; Yang, Zixia; Xiao, Yawen; Liu, Ran; Jia, Jing; Zhang, Xinrui; Zhang, Yuting; Fu, Zheng; Yao, Zhi; Lv, Junqiang

Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance.

核定位的 BCKDK 促进同源重组修复,从而支持乳腺癌进展和治疗耐药性

Liu Haiying, Feng Jiaqian, Pan Tingting, Zhang Pinggen, Ye Ling, Jiang Zetan, Zhou Zilong, Mao Qiankun, Li Jian, Yang Xinyi, Gao Ping, Huang De, Zhang Huafeng

Adenine base editing rescues disrupted BCKDH function and reduces BCAAs toxic accumulation in maple syrup urine disease patient iPSC-hepatic organoids

腺嘌呤碱基编辑可挽救受损的BCKDH功能,并减少枫糖尿症患者iPSC-肝脏类器官中BCAA的毒性积累

Haiyan Zhang #,Zirui Wan #,Xiaomei Li,Bin Wang,Jingyun Guan,Yue Li,Xiaohua Jin,Xu Ma,Guohua Liu

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

BCKDK 变构抑制剂导致血浆色氨酸脱靶消耗

Bowman Caitlyn E, Neinast Michael D, Kawakami Ryo, Forelli Nicholas, Jang Cholsoon, Patel Jiten, Blair Megan C, Noji Michael C, Mirek Emily T, Jonsson William O, Chu Qingwei, Merlo Lauren, Mandik-Nayak Laura, Anthony Tracy G, Rabinowitz Joshua D, Arany Zolt

PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm.

PRSS55 调节 BCAA 代谢,并与小鼠睾丸和精子中的 BCKDK 和 BCKDHA 相互作用。

Ge Haoyang, Shen Chunling, Xiong Wenfeng, Lu Shunyuan, Li Chaojie, Tang Lingyun, Shen Yan, Zhang Hongxin, Fei Jian, Wang Zhugang

BCKDK gene mutations as a rare condition responsible for comorbid neurodevelopmental delay, autism, and epilepsy: a case series of four patients

BCKDK基因突变是一种罕见疾病,可导致神经发育迟缓、自闭症和癫痫共病:四例病例系列研究

Karimzadeh, Parvaneh; Kachuei, Maryam; Najmabadi, Hossein; Keramatipour, Mohammad; Rezazadeh, Mohammad; Tasharrofi, Behnoosh; KamaliTabar, Fatemeh

Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis

全身性和胰腺特异性抑制BCKDK对胰腺癌发生的相反作用

Noji, Michael C; Demetriadou, Christina; Landis, Madelyn; Pennise, Jennifer; Pinheiro, Laura V; Jaccard, Alison; Chatoff, Adam; Drummond, Jack; Guo, Kevin; Azor, Romie; Robertson, Maggie R; Kawakami, Ryo; Marcinkiewicz, Mariola M; Tobias, John W; Snyder, Nathaniel W; Feldser, David; Arany, Zoltan; Wellen, Kathryn E

Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH

Mitolnc 通过变构激活 BCKDH 来调控心脏 BCAA 代谢和心脏肥大。

Maria Weiss ,Sara Hettrich ,Theresa Hofmann ,Salma Hachim ,Stefan Günther ,Thomas Braun ,Thomas Boettger

BCKDK modification enhances the anticancer efficacy of CAR-T cells by reprogramming branched chain amino acid metabolism

BCKDK修饰通过重编程支链氨基酸代谢增强CAR-T细胞的抗癌功效

Quanjun Yang ,Xinting Zhu ,Ping Huang ,Chunyan Li ,Leng Han ,Yonglong Han ,Run Gan ,Bo Xin ,Yixing Tu ,Shumin Zhou ,Ting Yuan ,Juan Hao ,Chunqiong Li ,Li Zhang ,Lei Shi ,Cheng Guo