BCL11A相关文献与解析，生知库 | 链接生命科学的每一步

Wang, Kaili; Wang, Juan; Feng, Ruopeng; Dudnyk, Kseniia; Kim, Yoon Jung; Lim, Jun Yi Stanley; Lee, Michael Jr; Zhang, Yuannyu; Gao, Xiaofei; Cheng, Yong; Orkin, Stuart H; Zhou, Jian; Weiss, Mitchell J; Yue, Feng; Xu, Jian

BCL11A

表观遗传

发表日期：2026

文献求助收藏

LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription.

LDB1 通过增强 BCL11A 转录来抑制胎儿血红蛋白的表达。

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2026.104070

Park Si-Won, Choi Chang-Yong, Park In-Byung, Kang Seok-Jin, Lee Hyeon Jeong, Kim Ji-In, Bae Joonbeom, Geum Dongho, Cheon Yong-Pil, Chun Taehoon

Circ_0001428 regulates erythropoiesis and Î³-globin expression via activating the ATF4-BCL11A axis in Î²-thalassemia.

Circ_0001428 通过激活 β-地中海贫血中的 ATF4-BCL11A 轴来调节红细胞生成和 β-珠蛋白表达。

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-026-06165-6

Li Jingmin, Pan Yali, Chen Meihuan, Zheng Junhao, Lin Siyang, Zheng Yanping, Zhang Shuning, Lin Na, Xu Liangpu, Huang Hailong

Whole Exome Sequencing in Patients With Developmental Delay/Intellectual Disability (DD/ID), Epilepsy and the First Turkish Patient Diagnosed With BCL11A-Related Intellectual Disability

对发育迟缓/智力障碍（DD/ID）、癫痫患者以及首例被诊断为BCL11A相关智力障碍的土耳其患者进行全外显子组测序

期刊:Molecular Genetics & Genomic Medicine

影响因子:1.6

doi:10.1002/mgg3.70180

Akkus, Nejmiye; Canbal, Abdullah; Guneysu, Seda; Gokce, Erkan; Duzgun, Pakize; Barıs, İbrahim

The WT 1-AS/miR-206 axis regulates the proliferation and migration of breast cancer through the cuproptosis related gene BCL11A

WT 1-AS/miR-206轴通过铜凋亡相关基因BCL11A调控乳腺癌细胞的增殖和迁移。

期刊:Translational Cancer Research

影响因子:1.5

doi:10.21037/tcr-2025-1448.

Jiasi Li,Huiliang Yang,Renwu Liu

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells.

人红细胞前体HUDEP-2细胞中BCL11A DNA结合和表达的调控。

期刊:

影响因子:

doi:10.64898/2026.02.06.704516

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

多聚体转录因子BCL11A利用两个锌指串联阵列结合成簇的短序列基序。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-58998-7

Horton, John R; Yu, Meigen; Zhou, Jujun; Tran, Melody; Anakal, Rithvi R; Lu, Yue; Blumenthal, Robert M; Zhang, Xiaotian; Huang, Yun; Zhang, Xing; Cheng, Xiaodong

BCL11A

发表日期：2025

文献求助收藏

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer

CHD8 与 BCL11A 相互作用，诱导三阴性乳腺癌中的致癌转录

期刊:EMBO Journal

影响因子:9.4

doi:10.1038/s44318-025-00447-8

Mark Waterhouse #,Kyren Lazarus #,Maria Francesca Santolla #,Sara Pensa,Eleanor Williams,Abigail J Q Siu,Hisham Mohammed,Irina Mohorianu,Marcello Maggiolini,Jason Carroll,Laura S Itzhaki,Taufiq Rahman,Walid T Khaled

Nonclinical evaluation of HBG1/2 and BCL11A as genome-editing targets for the treatment of β-hemoglobinopathies

HBG1/2 和 BCL11A 作为基因组编辑靶点治疗 β-血红蛋白病的非临床评估

期刊:Blood Advances

影响因子:7.1

doi:10.1182/bloodadvances.2024014040

Janoudi, Tusneem; Jagdale, Mrunali; Wu, Meng; Gorlla, Sanjana; Zhang, Peisheng; Shao, Ying; Li, Li; Bowley, Sheryl R; Marco, Eugenio; Chang, Kai-Hsin

BCL11A

发表日期：2025

文献求助收藏

Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc fingers

转录抑制因子BCL11A的Z0结构域的溶液结构揭示了蛋白质结合锌指的序列特性

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.70097

Harris, Rilee E; Whitehead, Richard D 3rd; Alexandrescu, Andrei T

BCL11A

发表日期：2025

文献求助收藏

Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation

通过破坏增强子依赖的表观遗传绝缘来沉默 BCL11A

LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription.

LDB1 通过增强 BCL11A 转录来抑制胎儿血红蛋白的表达。

Circ_0001428 regulates erythropoiesis and Î³-globin expression via activating the ATF4-BCL11A axis in Î²-thalassemia.

Circ_0001428 通过激活 β-地中海贫血中的 ATF4-BCL11A 轴来调节红细胞生成和 β-珠蛋白表达。

Whole Exome Sequencing in Patients With Developmental Delay/Intellectual Disability (DD/ID), Epilepsy and the First Turkish Patient Diagnosed With BCL11A-Related Intellectual Disability

对发育迟缓/智力障碍（DD/ID）、癫痫患者以及首例被诊断为BCL11A相关智力障碍的土耳其患者进行全外显子组测序

The WT 1-AS/miR-206 axis regulates the proliferation and migration of breast cancer through the cuproptosis related gene BCL11A

WT 1-AS/miR-206轴通过铜凋亡相关基因BCL11A调控乳腺癌细胞的增殖和迁移。

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells.

人红细胞前体HUDEP-2细胞中BCL11A DNA结合和表达的调控。

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

多聚体转录因子BCL11A利用两个锌指串联阵列结合成簇的短序列基序。

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer

CHD8 与 BCL11A 相互作用，诱导三阴性乳腺癌中的致癌转录

Nonclinical evaluation of HBG1/2 and BCL11A as genome-editing targets for the treatment of β-hemoglobinopathies

HBG1/2 和 BCL11A 作为基因组编辑靶点治疗 β-血红蛋白病的非临床评估

Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc fingers

转录抑制因子BCL11A的Z0结构域的溶液结构揭示了蛋白质结合锌指的序列特性