日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered receptors for soluble cellular communication and disease sensing

用于可溶性细胞通讯和疾病感知的工程受体

Dan I Piraner #, Mohamad H Abedi #, Maria J Duran Gonzalez #, Adam Chazin-Gray #, Annie Lin, Iowis Zhu, Pavithran T Ravindran, Thomas Schlichthaerle, Buwei Huang, Tyler H Bearchild, David Lee, Sarah Wyman, Young-Wook Jun, David Baker, Kole T Roybal6

Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation

供体MHC特异性胸腺疫苗接种可实现免疫相容性同种异体移植

Yang Liu # ,Hexi Feng # ,Ke Li # ,Ruiyi Li # ,Xiao-Jie Zhang ,Ye Tian ,Yujiang Fang ,Yanjie Zhou ,Ling Liu ,Xiaoqing Zhang

TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling

TET2 缺乏通过上调血小板生成素受体信号增强造血干细胞和祖细胞的竞争优势

Yitong Yang, Severine Cathelin, Alex C H Liu, Amit Subedi, Abdula Maher, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Robert Vanner, Steven M Chan

Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment

通过适应性内皮对人类胰岛进行血管化,以实现持久且功能性的皮下植入

Ge Li, Rebecca Craig-Schapiro, David Redmond, Kevin Chen, Yang Lin, Fuqiang Geng, Meng Gao, Sina Y Rabbany, Gayathri Suresh, Bradley Pearson, Ryan Schreiner, Shahin Rafii

The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway

癌相关成纤维细胞与凋亡癌细胞的相互作用通过WISP-1-整合素ανβ3-STAT1信号通路抑制肺癌细胞生长

Shinyoung Kim #,Kyungwon Yang #,Kiyoon Kim #,Hee Ja Kim,Da Young Kim,Jeesoo Chae,Young-Ho Ahn,Jihee Lee Kang

Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer

IL-7 和 IL-15 对幼稚调节性 T 细胞进行代谢重编程,促进其在过继转移后的持久性和性能

Jessica Filoni #, Arianna Ferrari #, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Giuseppe Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

Naturally occurring T cell mutations enhance engineered T cell therapies

自然发生的T细胞突变可增强工程化T细胞疗法的效果。

Julie Garcia #,Jay Daniels #,Yujin Lee,Iowis Zhu,Kathleen Cheng,Qing Liu,Daniel Goodman,Cassandra Burnett,Calvin Law,Chloë Thienpont,Josef Alavi,Camillia Azimi,Garrett Montgomery,Kole T Roybal,Jaehyuk Choi

Cholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma

表达 C1QB 的巨噬细胞的胆固醇流出与原发性难治性弥漫大 B 细胞淋巴瘤对嵌合抗原受体 T 细胞治疗的耐药性有关

Zi-Xun Yan #, Yan Dong #, Niu Qiao #, Yi-Lun Zhang, Wen Wu, Yue Zhu, Li Wang, Shu Cheng, Peng-Peng Xu, Zi-Song Zhou, Ling-Shuang Sheng, Wei-Li Zhao

Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease

开发和IND申报研究:一种新型Cas9基因编辑自体CD34+细胞疗法,用于诱导胎儿血红蛋白以治疗镰状细胞病。

Varun Katta,Kiera O'Keefe,Yichao Li,Thiyagaraj Mayuranathan,Cicera R Lazzarotto,Rachael K Wood,Rachel M Levine,Alicia Powers,Kalin Mayberry,Garret Manquen,Yu Yao,Jingjing Zhang,Yoonjeong Jang,Nikitha Nimmagadda,Erin A Dempsey,GaHyun Lee,Naoya Uchida,Yong Cheng,Frank Fazio,Tim Lockey,Mike Meagher,Akshay Sharma,John F Tisdale,Sheng Zhou,Jonathan S Yen,Mitchell J Weiss,Shengdar Q Tsai

Modulation of TCR stimulation and pifithrin-α improve the genomic safety profile of CRISPR-engineered human T cells

调节TCR刺激和pifithrin-α可改善CRISPR工程化人类T细胞的基因组安全性

Laurenz T Ursch,Jule S Müschen,Julia Ritter,Julia Klermund,Bettina E Bernard,Saskia Kolb,Linda Warmuth,Geoffroy Andrieux,Gregor Miller,Marina Jiménez-Muñoz,Fabian J Theis,Melanie Boerries,Dirk H Busch,Toni Cathomen,Kathrin Schumann