SMAD4相关文献与解析，生知库 | 链接生命科学的每一步

TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer

TGF-β/SMAD4/14-3-3σ/TFEB轴促进结直肠癌间质-上皮转化并抑制自噬

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08733-x

Chen, Xiaoyan; Winter, Markus; Rokavec, Matjaz; König, Janine; Hermeking, Heiko

Identification and characterization of a TGF-Î²-independent SMAD4-NFATc1-STAT3 regulatory axis.

鉴定和表征 TGF-β 非依赖性 SMAD4-NFATc1-STAT3 调控轴。

期刊:Journal of Molecular Cell Biology

影响因子:5.9

doi:10.1093/jmcb/mjaf028

Ouyang Wukun, Hao Jiaying, Niu Qiankun, Douglass Eugene F Jr, Beusch Christian M, Gordon David E, Hall Maggie, Moffitt Richard A, Du Yuhong, Mo Xiulei

High-Grade Colorectal Adenocarcinomas With SMAD4 Deficiency

SMAD4缺陷型高级别结直肠腺癌

期刊:Modern Pathology

影响因子:5.5

doi:10.1016/j.modpat.2025.100957

Mirzabeigi, Yasamin; Shah, Nikunj; Schwartz, Kayla R; Duryea, Jeffrey; Delma, Katiana S; Montgomery, Elizabeth A; Poveda, Julio C; McDonald, Oliver G

CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma.

CircSMAD4 在肺腺癌中塑造基质重塑 TAM。

期刊:Non-coding RNA Research

影响因子:4.7

doi:10.1016/j.ncrna.2026.03.003

Yu Zhengwei, Wang Xinyue, Zheng Yiqian, He Yifan, Lin Jiayu, Xiao Yue, Mo Bin, Xie Haoyu, Hang Sitong, Gao Xia, Xu Pei, Liu Yihao, Xiao Haibo

A 5-marker immunohistochemical panel of CK17, MEP1A, PAX8, SMAD4, and CDX2 to distinguish ovarian mucinous carcinoma from metastatic pancreatic ductal adenocarcinoma

采用 CK17、MEP1A、PAX8、SMAD4 和 CDX2 这 5 种标记物的免疫组化检测方法，可鉴别卵巢黏液性癌和转移性胰腺导管腺癌。

期刊:Histopathology

影响因子:4.1

doi:10.1111/his.70002

De Boeck, Astrid; Kang, Eun Young; Meagher, Nicola S; Gorringe, Kylie L; Lee, Cheng Han; Minoo, Parham; Köbel, Martin

Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing

利用新一代测序技术检测巴西胰腺腺癌患者肿瘤细胞游离DNA中KRAS、TP53、CDKN2A和SMAD4的突变

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-42403-4

Marin, Anelis Maria; Timoner, Branca Engel; Araújo, Diogo Dias; Uno, Miyuki; Alves, Maria José Ferreira; Chammas, Roger; Namur, Guilherme Naccache; Wosniaki, Denise Kusma; Canzian, Federico; Blanes, Lucas; Zanette, Dalila Lucíola; Aoki, Mateus Nóbrega

Clinical impact of the methylation status of SMAD4 and AKR1B1 genes in a liquid biopsy sample as a prognostic marker for breast cancer

SMAD4和AKR1B1基因甲基化状态在液体活检样本中作为乳腺癌预后标志物的临床意义

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-37937-6

Swellam, Menha; Ramadan, Amal; Sobeih, Mohamed Emam; Bakr, Noha M

Association of SMAD4 gene polymorphisms with human papillomavirus infection and risk of cervical cancer: a case-control study

SMAD4基因多态性与人乳头瘤病毒感染及宫颈癌风险的关联：一项病例对照研究

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-026-15552-y

Wang, Yongliang; Deng, Ying; Wei, Ying; Wang, Chunfang; Teng, YuanJi

Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway

乙胺丁醇通过Smad4通路诱导视网膜神经节细胞发生SDHB介导的铁死亡，从而导致视神经病变。

期刊:Human Cell

影响因子:3.4

doi:10.1007/s13577-025-01342-4

Qiushi Li #,Wei Ge #,Yifan Zhang,Qibin Xu,Junli Xu,Yu Zhang,Xingneng Guo,Wenyan Sheng,Liwei Zhu

Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein

用于靶向突变SMAD4蛋白的新半胱氨酸分子胶

TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer

TGF-β/SMAD4/14-3-3σ/TFEB轴促进结直肠癌间质-上皮转化并抑制自噬

Identification and characterization of a TGF-Î²-independent SMAD4-NFATc1-STAT3 regulatory axis.

鉴定和表征 TGF-β 非依赖性 SMAD4-NFATc1-STAT3 调控轴。

High-Grade Colorectal Adenocarcinomas With SMAD4 Deficiency

SMAD4缺陷型高级别结直肠腺癌

CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma.

CircSMAD4 在肺腺癌中塑造基质重塑 TAM。

A 5-marker immunohistochemical panel of CK17, MEP1A, PAX8, SMAD4, and CDX2 to distinguish ovarian mucinous carcinoma from metastatic pancreatic ductal adenocarcinoma

采用 CK17、MEP1A、PAX8、SMAD4 和 CDX2 这 5 种标记物的免疫组化检测方法，可鉴别卵巢黏液性癌和转移性胰腺导管腺癌。

Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing

利用新一代测序技术检测巴西胰腺腺癌患者肿瘤细胞游离DNA中KRAS、TP53、CDKN2A和SMAD4的突变

Clinical impact of the methylation status of SMAD4 and AKR1B1 genes in a liquid biopsy sample as a prognostic marker for breast cancer

SMAD4和AKR1B1基因甲基化状态在液体活检样本中作为乳腺癌预后标志物的临床意义

Association of SMAD4 gene polymorphisms with human papillomavirus infection and risk of cervical cancer: a case-control study

SMAD4基因多态性与人乳头瘤病毒感染及宫颈癌风险的关联：一项病例对照研究

Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathway

乙胺丁醇通过Smad4通路诱导视网膜神经节细胞发生SDHB介导的铁死亡，从而导致视神经病变。