SP3相关文献与解析，生知库 | 链接生命科学的每一步

Schäfer, Daniel; Prieto-Garcia, Cristian; Wang, Jianhui; Heinz, Marcel; Matkovic, Vigor; Kielkowski, Pavel; Hasselbeck, Sebastian; Shah, Varun Jayeshkumar; Knapp, Stefan; Hummer, Gerhard; Dikic, Ivan; Cheng, Xinlai

SP3

发表日期：2026

文献求助收藏

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer.

USP35 作为 ID3 的去泛素化酶，促进结直肠癌的免疫逃逸。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202516588

Chen Wenxin, Wang Ling, Fan Hongmei, Li Lisheng, Zhang Lingyu, Li Ruoxin, Liu Fang, Wen Fuli, Ye Yunbin, Huang Chuanzhong

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle.

USP30 的激活通过调节 S-腺苷甲硫氨酸循环破坏内皮细胞功能并加重急性肺损伤。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202512807

Baoyinna Baoyinna, He Jinshan, Miao Jiaxing, Shaheen Nargis, Xia Boyu, Wang Cankun, Ma Qin, Bernier Matthew C, Whitson Bryan A, Sun Nuo, Zhao Jing, Zhao Yutong

Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo

单细胞RNA序列分析揭示USP32可作为治疗靶点，在体外和体内均能减轻PD-L1驱动的结直肠肿瘤发生。

期刊:Theranostics

影响因子:13.3

doi:10.7150/thno.117900

Birappa, Girish; Perumalsamy, Haribalan; Hong, Seok-Ho; Gowda, D A Ayush; Chandrasekaran, Arun Pandian; Karapurkar, Janardhan Keshav; Rajkumar, Sripriya; Balusamy, Sri Renukadevi; Jayachandran, Aparna; Baek, Kwang-Hyun; Lee, Junwon; Matam, Viswanathaiah; Kim, Woo Jin; Kim, Kye-Seong; Ramakrishna, Suresh; Suresh, Bharathi

USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression.

USP30 介导的己糖激酶 2 去泛素化控制葡萄糖的代谢命运和肿瘤进展。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08459-w

CHK2-USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis

CHK2-USP37轴稳定FOXO4以维持衰老并逃避细胞凋亡

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2526252123

Sun, Jiahui; Geng, Anke; Song, Zhiwei; Chen, Lingjiang; Zhang, Zhen-Ning; Jiang, Ying; Mao, Zhiyong

USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer

USP3在缺氧应激下通过去泛素化作用稳定MIC19，并促进非小细胞肺癌的进展。

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01625-4

Zhao, Wen-Hao; Huang, Hua; Ding, Chen; Zhao, Ze-Xia; Jia, Chao-Yi; Wang, Ying-Jie; Hu, Zi-Xuan; Wang, Guan-Nan; Li, Yong-Wen; Liu, Jing-Hao; Liu, Hong-Yu; Chen, Jun

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.

USP39 抑制 MLKL 磷酸化和去泛素化，从而抑制髓核细胞坏死，减轻椎间盘退变。

期刊:Journal of Orthopaedic Translation

影响因子:7.8

doi:10.1016/j.jot.2025.101039

Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.

Raptor 和 GLI1 被鉴定为 USP37 的底物，突显了其在髓母细胞瘤细胞中的特定功能。

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-025-03651-2

Singh Ashutosh, Cheng Donghang, Haltom Amanda R, Yang Yanwen, Dobson Tara, Hatcher Rashieda, Rajaram Veena, Gopalakrishnan Vidya

USP30-AS1 functions as a post-transcriptional amplifier of interferon signalling to drive autoimmune pathogenesis

USP30-AS1作为干扰素信号的转录后放大器，驱动自身免疫发病机制。

期刊:Cell and Bioscience

影响因子:6.2

doi:10.1186/s13578-026-01548-5

Pan, Jie; Feng, Min-Yi; Xia, Tian; Jiang, Shuai; Zhu, Peng-Peng; Yu, Xi-Ping; Su, Zhi-Hui; Liu, Yu; Wu, Jia-Qi; Zhao, Ming; Li, Tao; Xue, Wen; Yu, Yu; Chen, Liang; Cai, Hong

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation

通过变构配体和PROTAC诱导降解靶向剪接体蛋白USP39

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer.

USP35 作为 ID3 的去泛素化酶，促进结直肠癌的免疫逃逸。

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S-Adenosylmethionine Cycle.

USP30 的激活通过调节 S-腺苷甲硫氨酸循环破坏内皮细胞功能并加重急性肺损伤。

Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis in vitro and in vivo

单细胞RNA序列分析揭示USP32可作为治疗靶点，在体外和体内均能减轻PD-L1驱动的结直肠肿瘤发生。

USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression.

USP30 介导的己糖激酶 2 去泛素化控制葡萄糖的代谢命运和肿瘤进展。

CHK2-USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis

CHK2-USP37轴稳定FOXO4以维持衰老并逃避细胞凋亡

USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer

USP3在缺氧应激下通过去泛素化作用稳定MIC19，并促进非小细胞肺癌的进展。

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.

USP39 抑制 MLKL 磷酸化和去泛素化，从而抑制髓核细胞坏死，减轻椎间盘退变。

Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.

Raptor 和 GLI1 被鉴定为 USP37 的底物，突显了其在髓母细胞瘤细胞中的特定功能。

USP30-AS1 functions as a post-transcriptional amplifier of interferon signalling to drive autoimmune pathogenesis

USP30-AS1作为干扰素信号的转录后放大器，驱动自身免疫发病机制。