日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation

TRIM24介导的ULK1 K27连接的泛素化可减轻能量应激诱导的自噬,并在SPOP突变的情况下促进前列腺癌的生长。

Chen, Shimin; Lin, Jichun; Yang, Zhan; Wang, Yuanjing; Wang, Qiang; Wang, Dong; Qu, Yue; Lin, Qian; Liu, Jia; Yan, Shi; Wang, Zixin; Qian, Xueyu; Xiao, Yutian; Li, Xue; Chen, Yinuo; Fang, Wenshuo; Zhao, Jiaojiao; Lu, Zhimin; Ren, He; Zhu, Yasheng; Ma, Leina

Paroxetine repurposing enhances antitumor immunity via SPOP-mediated PD-L1 ubiquitination and proteasomal degradation

帕罗西汀的重新定位通过SPOP介导的PD-L1泛素化和蛋白酶体降解增强抗肿瘤免疫力。

Xu, Mengting; Tian, Saisai; Xu, Hanchi; Xue, Xinying; Zhang, Qing; Hu, Hongmei; Wu, Gaosong; Geng, Xiangxin; Yu, Dianping; Xu, Hanchen; Xie, Mei; Li, Linyang; Li, Xinru; Li, Simeng; Xie, Shize; Lin, Xuwen; Lyu, Shuzhen; Xie, Yutong; Zhang, Biao; Zhou, Haiyang; Wang, Qun; Zhang, Weidong; Liu, Sanhong

CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.

通过操纵 SPOP-USP2 轴使 CD47 不稳定,可增强巨噬细胞的吞噬作用和癌症免疫疗法。

Yan Peiqiang, Bu Xia, Hou Tao, Chen Li, Zhong Guoxuan, Huang Daoyuan, Wang Jingchao, Qi Yihang, Jiang Weiwei, Li Zhe, Xue Xutong, Gao Yang, Liu Jing, Inuzuka Hiroyuki, Freeman Gordon J, Wei Wenyi, Dai Xiaoming

Reduced YTHDF2 inhibits PD-L1 expression by stabilizing m(6)A-containing SPOP mRNA in colorectal cancer.

结直肠癌中 YTHDF2 的减少通过稳定含有 m(6)A 的 SPOP mRNA 来抑制 PD-L1 的表达。

Xu Xian, Chen Hao, Zhao Rongjie, Xie Jiansheng, Liu Hao, Xie Binbin, Lou Jun, Wang Haidong, Wu Xinkai, Han Weidong, Pan Hongming, Shen Jiaying

The Clinical Significance of SPOP Upregulation and Nuclear Accumulation in Head and Neck Squamous Cell Carcinoma

SPOP上调和核内积聚在头颈部鳞状细胞癌中的临床意义

Shih, Yin-Hwa; Lin, Nan-Chin; Shen, Yen-Wen; Tu, Ming-Gene; Wang, Tong-Hong; Tseng, Yu-Hsin; Hsia, Shih-Min; Shieh, Tzong-Ming

Systematic Characterization of Cancer-Associated SPOP Mutants Reveals Novel and Reprogrammable Degradative Activities

对癌症相关SPOP突变体的系统性表征揭示了新型且可重编程的降解活性

Caldwell, Alana G; Parmar, Harshil; Jin, Xiaokang; Zhou, Chen; Zhang, Xiaoyu

Outcomes for Patients With SPOP Mutated Castration-Resistant Prostate Cancer (CRPC) Treated With an Androgen Receptor Pathway Inhibitor (ARPI)

使用雄激素受体通路抑制剂 (ARPI) 治疗 SPOP 突变去势抵抗性前列腺癌 (CRPC) 患者的疗效

Park, Joseph J; Howard, Lauren E; Fragkogianni, Stamatina; George, Daniel J; Armstrong, Andrew J

Correction: SPOP‑mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

更正:SPOP介导的PDK1泛素化和降解抑制AKT激酶活性和致癌功能

Jiang, Qiwei; Zheng, Nana; Bu, Lang; Zhang, Xiaomei; Zhang, Xiaoling; Wu, Yuanzhong; Su, Yaqing; Wang, Lei; Zhang, Xiaomin; Ren, Shancheng; Dai, Xiangpeng; Wu, Depei; Xie, Wei; Wei, Wenyi; Zhu, Yasheng; Guo, Jianping

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer

基于网络医学的策略发现,马普替林可通过靶向SPOP抑制PD-L1表达,从而成为一种可重新利用的药物。

Tian, Saisai; Xu, Mengting; Geng, Xiangxin; Fang, Jiansong; Xu, Hanchen; Xue, Xinying; Hu, Hongmei; Zhang, Qing; Yu, Dianping; Guo, Mengmeng; Zhang, Hongwei; Lu, Jinyuan; Guo, Chengyang; Wang, Qun; Liu, Sanhong; Zhang, Weidong

Molecular glue degrader function of SPOP inhibitors enhances STING-dependent immunotherapy efficacy in melanoma models.

SPOP抑制剂的分子胶降解功能增强了黑色素瘤模型中STING依赖性免疫疗法的疗效。