日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling.

SIRT2 介导的 LCK 去乙酰化控制着 T 细胞受体信号的强度。

Hamaidi Imene, Cheng Pingyan, Jun Soo Young, Manna Alak, Wang Min-Hsuan, Nguyen Anh, Can Ismail, Zhang Min G, Taylor Odesha O, Bailon Luis Uriel Lopez, Fang Bin, Perez Bradford, Creelan Ben C, Marusyk Andriy, Shin Dongjun, Hwang Tae Hyun, Berglund Anders E, Shapiro Virginia S, Ji Haitao M, Conejo-Garcia José R, Kim Sungjune

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.

SIRT2 对 MRE11 的去乙酰化作用促进 DNA 结合,从而促进 DNA 末端切除和 ATM 依赖性信号传导。

Sesay Fatmata, Zhang Hui, Kapoor-Vazirani Priya, Jung Andrew T, Essien Mark E, Bastien Amanda J, Luong Nho C, Liu Xu, Head PamelaSara E, Duong Duc M, Yang Xiaofeng, Buchwald Zachary S, Deng Xingming, Seyfried Nicholas T, Yu David S

SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells.

SIRT2 通过促进上皮干细胞中同源重组介导的 DNA 双链断裂修复来减轻辐射引起的口腔黏膜炎。

Patra Mousumi, Sadhukhan Ratan, Allen Eva, Kalantari Faraz, Allam Heba, Xia Fen

SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized Mice

SirT2抑制与嗅球切除小鼠抑郁样行为和记忆障碍的改善相关

Takahashi, Kohei; Kurokawa, Kazuhiro; Hiraga, Daiki; Takeda, Hiroshi; Tsuji, Minoru

Structure-Guided Optimization and Biological Validation of 1,3,4-Thiadiazole-Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions.

基于结构的 1,3,4-噻二唑 SIRT2 抑制剂的优化和生物学验证,增强了通道入口相互作用。

Aksel Ahmet Bugra, Ozgencil Fikriye, Bakar-Ates Filiz, Gunindi Habibe Beyza, Massarotti Alberto, Ozkan Erva, Kaya Selen Gozde, Gozelle Mahmut, Ozkan Yesim, Eren Gokcen

The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation.

蛋白质脱乙酰酶 SIRT2 对适应性 β 细胞增殖发挥代谢控制作用。

Wortham Matthew, Ramms Bastian, Zeng Chun, Benthuysen Jacqueline R, Sai Somesh, Pollow Dennis P, Liu Fenfen, Schlichting Michael, Harrington Austin R, Liu Bradley, Prakash Thazha P, Pirie Elaine C, Zhu Han, Baghdasarian Siyouneh, Lee Sean T, Ruthig Victor A, Wells Kristen L, Auwerx Johan, Shirihai Orian S, Sander Maike

SIRT2 Inhibition promotes microglia LC3-associated phagocytosis via NRF2/CD36 after the experimental subarachnoid hemorrhage.

SIRT2 抑制可促进实验性蛛网膜下腔出血后小胶质细胞通过 NRF2/CD36 进行 LC3 相关吞噬作用。

Sheng Bin, Chen Xiangxin, Tao Tao, Sun Jiaqing, Li Wei, Wu Lingyun, Peng Zheng, Li Xiaojian, Zhou Zhengxu, Yu Qian, Ling Yeping, Sherchan Prativa, Flores Jerry J, Tang Jiping, Huang Lei, Hang Chunhua, Zhang John H

Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis

肝细胞癌细胞通过SIRT2介导的去乙酰化修饰下调PGAM2,从而增强有氧糖酵解。

Zexuan Wang #,Yaoyu Guo #,Kefei Hu,Tingjiang He,Tong Qin,Ludan Zhang,Fang Xu,Yuanzhi Xu,Mingjiao Cheng,Jintao Zhang,Qianwei Zhao

Mechanistic Insights Into Celastrol's Anti-Pyroptosis Effects in Osteoarthritis via SIRT2 Upregulation.

通过 SIRT2 上调揭示雷公藤内酯醇在骨关节炎中发挥抗细胞焦亡作用的机制。

Chen Xiaotian, Song Yining, Zhang Fan, Hu Fangyan, Ding Zhenfei, Guan Jianzhong

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Schistosoma mansoni Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages.

苯并二氮杂黄素 Sirtuin 抑制剂抑制曼氏血吸虫 Sirt2,导致血吸虫幼虫和成虫阶段的表型变化和致死性。

Gimmelli Roberto, Papoff Giuliana, Fabbrizi Emanuele, Guida Michela, Lalli Cristiana, Saccoccia Fulvio, Häberli Cécile, Keiser Jennifer, Monaldi Daria, Jung Manfred, Romier Christophe, Rotili Dante, Mai Antonello, Ruberti Giovina