日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons.

磷酸化tau蛋白具有抗菌活性,能够中和人类神经元中单纯疱疹病毒1型的感染性。

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss.

Tau 寡聚体通过引发渐进性双部分突触功能紊乱和突触丢失来调节突触命运。

Pareja-Navarro Kristeen A, King Christina D, Kauwe Grant, Ngwala Yani Y, Lokitiyakul Doyle, Wong Ivy, Vira Aaryan, Liu Yaofu, Chen Jackson H, Sharma Mahima, Navarro Gabriel, Malak Olfat, Zhou Chuankai, Schilling Birgit, Tracy Tara E

Tubulin transforms Tau and α-synuclein condensates from pathological to physiological.

微管蛋白将 Tau 蛋白和 α-突触核蛋白凝聚体从病理状态转化为生理状态。

Lucas Lathan, Tsoi Phoebe S, Quan My Diem, Choi Kyoung-Jae, Ferreon Josephine C, Ferreon Allan Chris M

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.

致病性 Tau 突变导致自噬溶酶体功能障碍,从而限制额颞叶痴呆模型中 Tau 的降解。

Mirfakhar Farzaneh S, Marsh Jacob A, Sato Chihiro, Schache Kylie J, Minaya Miguel A, Dolle Roland E, Pak Stephen C, Silverman Gary A, Perlmutter David H, Macauley Shannon L, Karch Celeste M

TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA

TGFβ1 通过 Alu 元件驱动的 STAU1 介导的 CDH1 mRNA 衰变激活 Lnc-APUE 促进肿瘤转移

Li, Song-Yang; Huang, Jia-Hui; Yang, Jin-E; Li, Yi-Hang; Hong, Juan-Zhen; Wang, Ting-Ting; Chi, Ying-Lei; Wu, Meng-Zhi; Wang, Wei; Zhu, Ying; Zhuang, Shi-Mei

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.

TP53/TAU轴调节微管束形成,从而控制肺泡干细胞介导的再生。

Konishi Satoshi, Enkhbayar Khaliun, Liu Shuyu, Miyashita Naoya, Kobayashi Yoshihiko, Hutchison Vera, Sai Ashna, Agarwal Pankaj, Witonsky Jonathan, Jackson Nathan D, Seibold Max A, Chen Jichao, Tata Aleksandra, Tata Purushothama Rao

Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments.

随着年龄增长,Nr4a1 水平升高,PI3K/AKT/GSK3β 通路减弱,介导 tau 蛋白过度磷酸化和认知障碍。

Neurons with granulovacuolar degeneration bodies are resilient to tau-induced protein synthesis impairment.

具有颗粒空泡变性体的神经元对 tau 蛋白诱导的蛋白质合成障碍具有抵抗力。

Smits Jasper F M, Ligthart Thijmen W, Jorge-Oliva Marta, Middelhoff Skip, Schipper Fleur, Pita-Illobre Débora, Li Ka Wan, Scheper Wiep

GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

GASDERMIN D 介导的细胞焦亡作为 TAU 依赖性额颞叶痴呆小鼠模型的治疗靶点

Silva-Llanes, Ignacio; Smith, Lilia A; Abdelkader-Guillén, Aaron; Jiménez-Villegas, José; Sarrió, David; Moreno-Bueno, Gema; Lastres-Becker, Isabel