TBK1相关文献与解析，生知库 | 链接生命科学的每一步

Disrupted autophagy overactivates TBK1 and results in mitotic defects promoting chromosomal instability.

自噬功能紊乱会过度激活 TBK1，导致有丝分裂缺陷，从而促进染色体不稳定。

doi:10.1080/15548627.2026.2617844

Paul Swagatika, Tomsick Porter L, Milner Julia P, Biswas Sahitya Ranjan, Brindley Samantha, DeFoor Nicole, Zavar Leila, Wright Grace, Soto Yairis, Pickrell Alicia M

Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.

通过协调 p-TBK1 介导的线粒体自噬和异噬来限制细胞内沙门氏菌的增殖。

期刊:Autophagy

影响因子:14.3

doi:10.1080/15548627.2025.2534298

Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cells.

在 PEX1 缺失的 HeLa 细胞中，通过新型 TBK1-MARCHF7-PXMP4-NBR1 轴调控过氧化物酶体自噬。

期刊:Autophagy

影响因子:14.3

doi:10.1080/15548627.2025.2593585

Tissue-Resident Macrophage-Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p-TBK1

组织驻留巨噬细胞来源的E3连接酶SMURF2通过介导p-TBK1的降解来限制自身免疫性炎症

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202504930

An, Xiang; Li, Jun; Wang, Lingling; Li, Chengyuan; Jin, Zhenpeng; Yao, Yushi; Jiang, Minmin; Lin, Wenlong; Wang, Xiaojian

Immunology/Inflammation

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

TBK1诱导Optineurin丝状体的形成，该丝状体与多聚泛素和LC3凝聚，从而隔离货物。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202509927

Herrera, Maria G; Kühn, Lena; Jungbluth, Lisa; Bader, Verian; Krause, Laura J; Kartte, David; Adriaenssens, Elias; Martens, Sascha; Tatzelt, Jörg; Sachse, Carsten; Winklhofer, Konstanze F

TBK1

发表日期：2026

文献求助收藏

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

鱼类 CDK2 招募 Dtx4，通过泛素化作用降解 TBK1，从而参与抗病毒反应。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.98357

Lu, Long-Feng; Zhang, Can; Li, Zhuo-Cong; Cui, Bao-Jie; Wang, Yang-Yang; Han, Ke-Jia; Xu, Xiao; Zhou, Chu-Jing; Zhou, Xiao-Yu; Wu, Yue; Xu, Na; Yang, Xiao-Li; Chen, Dan-Dan; Li, Xiyin; Zhou, Li; Li, Shun

TBK1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Mechanistic Insights into Impaired Autophagy and Proteostatic Failure

肌萎缩侧索硬化症和额颞叶痴呆中的TBK1突变：自噬受损和蛋白质稳态失衡的机制解析

期刊:Cells

影响因子:5.2

doi:10.3390/cells15050477

Manganelli, Francesca; Perfetto, Camilla; Carletta, Olga; Gerbino, Valeria

Aberrant Accumulation of Cell-Free DNA Activates the cGAS-STING-TBK1 Pathway of γδ T Cells to Promote the Inflammatory Responses in Oral Lichen Planus

游离DNA异常积累激活γδ T细胞的cGAS-STING-TBK1通路，促进口腔扁平苔藓的炎症反应

期刊:Inflammation

影响因子:5

doi:10.1007/s10753-025-02416-z

Wei, Xin-Yi; Tan, Ya-Qin; Zhou, Gang

Dynamic regulation of TBK1 lactylation shapes antiviral immune responses.

TBK1 乳酸化的动态调控塑造抗病毒免疫反应。

TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons

TBK1调控人类神经元中的自噬和内吞溶酶体途径

Disrupted autophagy overactivates TBK1 and results in mitotic defects promoting chromosomal instability.

自噬功能紊乱会过度激活 TBK1，导致有丝分裂缺陷，从而促进染色体不稳定。

Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.

通过协调 p-TBK1 介导的线粒体自噬和异噬来限制细胞内沙门氏菌的增殖。

Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cells.

在 PEX1 缺失的 HeLa 细胞中，通过新型 TBK1-MARCHF7-PXMP4-NBR1 轴调控过氧化物酶体自噬。

Tissue-Resident Macrophage-Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p-TBK1

组织驻留巨噬细胞来源的E3连接酶SMURF2通过介导p-TBK1的降解来限制自身免疫性炎症

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

TBK1诱导Optineurin丝状体的形成，该丝状体与多聚泛素和LC3凝聚，从而隔离货物。

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

鱼类 CDK2 招募 Dtx4，通过泛素化作用降解 TBK1，从而参与抗病毒反应。

TBK1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Mechanistic Insights into Impaired Autophagy and Proteostatic Failure

肌萎缩侧索硬化症和额颞叶痴呆中的TBK1突变：自噬受损和蛋白质稳态失衡的机制解析

Aberrant Accumulation of Cell-Free DNA Activates the cGAS-STING-TBK1 Pathway of γδ T Cells to Promote the Inflammatory Responses in Oral Lichen Planus

游离DNA异常积累激活γδ T细胞的cGAS-STING-TBK1通路，促进口腔扁平苔藓的炎症反应