日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Defining cellular responses to HDAC-selective inhibitors reveals that efficient targeting of HDAC3 is required to elicit cytotoxicity and overcome naïve resistance to pan-HDACi in diffuse large B cell lymphoma

定义细胞对 HDAC 选择性抑制剂的反应表明,需要有效靶向 HDAC3 来引发细胞毒性并克服弥漫大 B 细胞淋巴瘤对泛 HDACi 的初始耐药性

Aaron P Havas, Ana A Tula-Sanchez, Hailey M Steenhoek, Anvi Bhakta, Taylor Wingfield, Matthew J Huntley, Angela S Nofal, Tasmia Ahmed, Rosa Jaime-Frias, Catharine L Smith

miR-424/503 modulates Wnt/β-catenin signaling in the mammary epithelium by targeting LRP6

miR-424/503通过靶向LRP6调节乳腺上皮细胞中的Wnt/β-catenin信号通路。

Erin A Nekritz # ,Ruth Rodriguez-Barrueco # ,Koon-Kiu Yan ,Meredith L Davis ,Rachel L Werner ,Laura Devis-Jauregui ,Partha Mukhopadhyay ,Jiyang Yu ,David Llobet-Navas ,Jose Silva

MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes

MeCP2 抑制高度甲基化的长基因的转录起始率

Lisa D Boxer, William Renthal, Alexander W Greben, Tess Whitwam, Andrew Silberfeld, Hume Stroud, Emmy Li, Marty G Yang, Benyam Kinde, Eric C Griffith, Boyan Bonev, Michael E Greenberg

Identification and Functional Characterization of Phosphorylation Sites of the Human Papillomavirus 31 E8^E2 Protein

人乳头瘤病毒 31 E8^E2 蛋白磷酸化位点的鉴定及功能特性

Saskia van de Poel, Marcel Dreer, Ana Velic, Boris Macek, Praveen Baskaran, Thomas Iftner, Frank Stubenrauch

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

小鼠 MeCP2 的生物素标记揭示了 Rett 综合征转录组的背景见解

Brian S Johnson, Ying-Tao Zhao, Maria Fasolino, Janine M Lamonica, Yoon Jung Kim, George Georgakilas, Kathleen H Wood, Daniel Bu, Yue Cui, Darren Goffin, Golnaz Vahedi, Tae Hoon Kim, Zhaolan Zhou

Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes

MeCP2 T158M 表达升高可挽救 DNA 结合和雷特综合征样表型

Janine M Lamonica, Deborah Y Kwon, Darren Goffin, Polina Fenik, Brian S Johnson, Yue Cui, Hengyi Guo, Sigrid Veasey, Zhaolan Zhou

Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders

MeCP2-TBLR1 复合物的结构揭示了雷特综合征及其相关疾病的分子基础

Valdeko Kruusvee, Matthew J Lyst, Ceitidh Taylor, Žygimantė Tarnauskaitė, Adrian P Bird, Atlanta G Cook

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

细胞质全长新型裂解变体 TBLR1 可降低雄激素缺乏状态下前列腺癌细胞的凋亡

Garrett Daniels, Xinmin Zhang, Xuelin Zhong, Larion Santiago, Ling Hang Wang, Xinyu Wu, Jack Y Zhang, Fengxia Liang, Xin Li, Thomas A Neubert, Laurey Steinke, Ying Shen, Ross Basch, Robert Schneider, David E Levy, Peng Lee

Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model

TBL1XR1 的缺失会破坏糖皮质激素受体向染色质的募集,并导致 B 淋巴细胞白血病模型产生糖皮质激素耐药性

Courtney L Jones, Teena Bhatla, Roy Blum, Jinhua Wang, Steven W Paugh, Xin Wen, Wallace Bourgeois, Danielle S Bitterman, Elizabeth A Raetz, Debra J Morrison, David T Teachey, William E Evans, Michael J Garabedian, William L Carroll

Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors

核共调节器的差异募集指导突变甲状腺激素受体的异构体依赖性作用

Laura Fozzatti, Changxue Lu, Dong-Wook Kim, Sheue-yann Cheng