日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4

BRD4 与 ASXL1 基因组靶标的结合依赖于 BRD4 的末端外结构域。

Selvam, Karthik; Lu, Shuang; Messmer, Clémence; Pang, Yakun; Biswas, Soumi; Khalil, Moustafa; Zhang, Peng; Tulaiha, Rima; Zhou, Ming-Ming; Kitamura, Toshio; Lauberth, Shannon M; Blanco, M Andres; Yang, Feng-Chun; Affar, El Bachir; Zhao, Zibo; Zeng, Lei; Wang, Lu; Kutateladze, Tatiana G

Identification of A p300-SP1-BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

鉴定p300-SP1-BRD4转录轴为多囊卵巢综合征中雄激素受体过度激活的关键驱动因素

Zhu, Zhengquan; Wang, Yihan; Chen, Haiyun; Yu, Xinye; Wang, Tingyu; Weng, Yajing; Guo, Meihong; Huang, Ying; Tao, Gaojian; Cao, Wangsen; Wang, Yong; Wang, Daojuan

A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy

一种时空可控的纳米平台用于光热降解BRD4,可实现协同癌症免疫疗法

Wang, Luyi; Wu, Jiasha; Ji, Rui; Qiang, Sufeng; Shen, Yulin; Zuo, Yan; Jian, Shiqin; Liu, Siyao; Xu, Fusheng; Hu, Honggang; Hu, Xiaochun

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood-Brain Barrier Integrity via Rnf43/β-Catenin Signaling Pathway.

Brd4 BD1 结构域对 MS436 的拮抗作用通过 Rnf43/β-catenin 信号通路维持血脑屏障的完整性。

Li Chenxiao, Zhang Xiaochen, Xia Jiangwei, Liu Shuang, Du Yushan, Li Sihan, Zhang Shukui, Zhang Yong, Ji Fen, Jiao Jianwei, Zhang Jingjing

E2F1 K117 methylation by SETD6 disrupts BRD4-E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells.

SETD6 对 E2F1 K117 的甲基化会破坏 BRD4-E2F1 的结合,并调节前列腺癌细胞中 E2F1 的染色质结合和基因调控。

Ulu Gizem Tugce, Kublanovsky Margarita, Shalev Raz, Biton Tzofit Elbaz, Feldman Michal, Murr Sophia, Brockmeyer Jens, Dorscht Franziska, Weirich Sara, Levy Dan, Jeltsch Albert

Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition

设计RGD功能化的GSH响应性聚乙二醇化聚合物蛋白,用于选择性降解BRD4和抑制EndMT驱动的心脏纤维化

Tao Bi #,Lei Chen #,Ting Wang,Wenjun Miao,Silong Zhai,Rui Huang,Qin Sun,Yihan Chen,Hongna Su,Jie Zhou,Ruowen Li,Weixue Huang,Xiaojun Yao,Pei Luo,Zengjin Liu

Ginsenoside Rh2- functionalized liposomes enhanced BRD4-PROTAC delivery and antitumor efficacy via improved tumor targeting and ECM remodeling

人参皂苷Rh2功能化脂质体通过改善肿瘤靶向性和ECM重塑增强BRD4-PROTAC递送和抗肿瘤疗效

Wen, Lijuan; Rao, Jialei; Chen, Jiaoting; Li, Fang; Chen, Xixi; Guo, Shenpeng; Cui, Binghui; Qiu, Caisheng; Chen, Weiliang

Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 Degraders

炔烃两相策略:快速生成TK-285衍生的PROTACs作为BRD4降解剂

Yamakoshi, Hiroyuki; Watanabe, Ryo; Segawa, Ryosuke; Ishihara, Ryosuke; Tachibana, Ryo; Kudo, Genki; Nagasawa, Shota; Yamanaka, Satoshi; Ito, Ayano; Takeda, Hiroyuki; Sawasaki, Tatsuya; Yoshino, Ryunosuke; Hirokawa, Takatsugu; Doi, Takayuki; Hirasawa, Noriyasu; Iwabuchi, Yoshiharu

BRD4 promotes endodermal cell fate during mammalian lung development.

BRD4 在哺乳动物肺发育过程中促进内胚层细胞命运。

Wen Hongbo, Liberti Derek C, Chandrasekaran Prashant, Parveen Shahana, Quansah Kwaku K, Kim Mijeong, Lange Ana N, Marquis Abigail T, Michki Sylvia N, Jin Annabelle, Lu MinQi, Fasan Ayomikun A, Suresh Sriyaa, Shirazi Shawyon P, Young Lisa R, Sucre Jennifer Ms, Basil Maria C, Jain Rajan, Frank David B

Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation

开发具有细胞活性的BRD4-D1选择性抑制剂,以揭示BET蛋白在LPS介导的肝脏炎症中的作用

Scholtz, Cole R; Doskey, Luke C; Kandanur, Sai Giridhar Sarma; Vail, Nora R; Roderick, Erika R; Peterson, Elliott J; Hoell, Zachariah J; Shi, Ke; Aihara, Hideki; Kostallari, Enis; Shah, Vijay H; Malhi, Harmeet; Pomerantz, William C K