TNF-α相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy

TWEAK受体（Fn14）会加剧类风湿性关节炎滑膜成纤维细胞中TNF-α诱导的炎症，并影响对TNF-α抑制剂治疗的反应。

期刊:Cellular & Molecular Immunology

影响因子:19.8

doi:10.1038/s41423-026-01386-y

Shaikh, Farheen S; Shanta, Meena A; Singh, Anil K; Daniels, Alexis M; Khuder, Sadik A; Thiele, Geoffrey M; Reed, George W; Kremer, Joel M; Pappas, Dimitrios A; Curtis, Jeffrey R; O'Dell, James R; Ouseph, Madhu M; Fox, David A; Ahmed, Salahuddin

成纤维细胞

细胞生物学

发表日期：2026

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TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation.

TNF-α 揭示肠道苹果酸天冬氨酸转运功能障碍，从而将帕金森病与肠道炎症联系起来。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-026-71317-y

Ghirotto Bruno, GonÃ§alves LuÃs Eduardo, Ruder Vivien, James Christina, Gerasimova Elizaveta, Rizo Tania, Wend Holger, Farrell Michaela, Gerez Juan Atilio, Prymaczok Natalia Cecilia, Kuijs Merel, Shulman Maiia, Hartebrodt Anne, Prots Iryna, Gessner Arne, Vieth Michael, Zunke Friederike, Winkler JÃ¼rgen, Blumenthal David B, Theis Fabian J, Riek Roland, GÃ¼nther Claudia, Neurath Markus, Gupta Pooja, Winner Beate

Immunology/Inflammation

发表日期：2026

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Tissue-adhesive hydrogel-MXene biosensor for in situ intraoral TNF-α detection

用于口腔内原位检测TNF-α的组织粘附水凝胶-MXene生物传感器

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.ady9180

Wong, Tsz Hung; Liu, Weijia; Li, Jiaoli; Ma, Jie; Cheng, Yijie; Lu, Ruihao; Koster, Kent J; Cirillo, Jeffrey D; Liu, Xinyue; Sasaki, Hajime; Wu, Chenglin; Lin, Shaoting

发表日期：2026

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A STING agonist potentiates C1 lipidoid-based mRNA cancer vaccine through promoting TNF-Î± secretion in vivo.

STING激动剂通过促进体内TNF-α分泌来增强基于C1类脂质的mRNA癌症疫苗的作用。

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.09.032

Zhang Hongxia, Lin Yang, Wang Liying, Cui Lei, Wang Zining, You Xinru, Xie Chunyuan, Zhang Huanling, Liu Yongxiang, Li Mengyun, Wang Xiaojuan, Wu Jun, Xia Xiaojun

发表日期：2026

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TNF-âº-mediated myeloid-instructed CD14(+)CD4(+) T cells are associated with poor survival in lung adenocarcinoma.

TNF-α介导的髓系指导的CD14(+)CD4(+) T细胞与肺腺癌患者的不良生存率相关。

期刊:Cell Reports Medicine

影响因子:10.6

doi:10.1016/j.xcrm.2026.102593

细胞生物学

发表日期：2026

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PtTe(2)-alginate hydrogels for combined photothermal-chemodynamic cancer therapy by inducing cell apoptosis via modulation of TNF-α-related signaling pathways

PtTe(2)-藻酸盐水凝胶通过调节TNF-α相关信号通路诱导细胞凋亡，用于光热-化学动力联合癌症治疗

期刊:Materials Today Bio

影响因子:10.2

doi:10.1016/j.mtbio.2025.102679

Tong, Jiayao; Qin, Jiaqi; Xing, Jianghao; Ren, Huansuo; Cao, Peng; Wang, Hui; Pan, Pengyu; Wang, Xianwen; Xue, Haowei

细胞生物学

发表日期：2026

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Immunomodulatory microneedles restore mitochondrial homeostasis and balance TGF-β/TNF-α signaling to accelerate diabetic wound repair

免疫调节微针可恢复线粒体稳态并平衡TGF-β/TNF-α信号通路，从而加速糖尿病伤口修复。

期刊:Materials Today Bio

影响因子:10.2

doi:10.1016/j.mtbio.2025.102687

Liao, Minjian; Guo, Xinmin; Feng, Longbao; Peng, Qing; Liang, Jianhao; Kuzniatsou, Aleh; Guo, Rui; Yu, Pan; Zhou, Shuqin

免疫/内分泌

发表日期：2026

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A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-Î± axis to potentiate melanoma immunotherapy.

一种基于紫红质的金属免疫刺激剂可放大 ROS 并调节 STING/TNF-α 轴，从而增强黑色素瘤免疫疗法。

期刊:Materials Today Bio

影响因子:10.2

doi:10.1016/j.mtbio.2026.102804

Yang Xiaoxin, Huang Mi, Pang Tianyi, Zhong Dong, Liu Hong, Chen Xiang, Liu Jun, Wen Yu

免疫/内分泌

发表日期：2026

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AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cell Function via TNF-α-FBP2 Signaling

巨噬细胞中AMPKα1的缺乏通过TNF-α-FBP2信号通路损害肌腱再生和肌腱干细胞功能

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.125245

Zhu, Lisha; Wang, Yu; Shi, Xinmeng; Yu, Min; Cai, Xinjia; Chen, Liyuan; Zhang, He; Wu, Xiaolan; Ding, Chengye; Liu, Hangbo; Zhang, Shiying; Li, Chang; Wu, Tianhao; Jiang, Nan; Liu, Yan

发育与干细胞

细胞生物学

免疫/内分泌

发表日期：2026

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Correction: Combined IFN-γ and TNF-α treatment enhances the susceptibility of breast cancer cells and spheroids to Natural Killer cell-mediated killing

更正：IFN-γ 和 TNF-α 联合治疗可增强乳腺癌细胞和球状体对自然杀伤细胞介导的杀伤作用的敏感性

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08381-7

Barberini, Francesca; Pietroni, Riccardo; Ielpo, Simone; Lucarini, Valeria; Nardozi, Daniela; Melaiu, Ombretta; Benvenuto, Monica; Focaccetti, Chiara; Palumbo, Camilla; Rossin, Federica; Fruci, Doriana; Olive, Daniel; Masuelli, Laura; Bei, Roberto; Cifaldi, Loredana

自然杀伤细胞

细胞生物学

发表日期：2026

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