日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNIK as a molecular switch regulating platelet function in hemostasis and hyperlipidemia-associated thrombosis

TNIK作为一种分子开关,在止血和高脂血症相关血栓形成中调节血小板功能。

Li, Li; Chen, Xiaoyan; Li, Jingke; Deng, Xin; Sheng, Yilin; Lu, Linrong; Hu, Hu

A system-wide investigation into the phosphoregulatory network of TNIK and its cellular implications

对TNIK磷酸化调控网络及其细胞意义的系统性研究

Sheela, Akhila; Subair, Suhail; Ummar, Samseera; Mahin, Althaf; Gopalakrishnan, Athira Perunelly; Raju, Rajesh; Soman, Sowmya

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

一种由人工智能发现的用于治疗特发性肺纤维化的TNIK抑制剂:一项随机2a期试验

Xu, Zuojun; Ren, Feng; Wang, Ping; Cao, Jie; Tan, Chunting; Ma, Dedong; Zhao, Li; Dai, Jinghong; Ding, Yipeng; Fang, Haohui; Li, Huiping; Liu, Hong; Luo, Fengming; Meng, Ying; Pan, Pinhua; Xiang, Pingchao; Xiao, Zuke; Rao, Sujata; Satler, Carol; Liu, Sang; Lv, Yuan; Zhao, Heng; Chen, Shan; Cui, Hui; Korzinkin, Mikhail; Gennert, David; Zhavoronkov, Alex

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

小分子 TNIK 抑制剂针对临床前和临床模型中的纤维化

Feng Ren, Alex Aliper, Jian Chen, Heng Zhao, Sujata Rao, Christoph Kuppe, Ivan V Ozerov, Man Zhang, Klaus Witte, Chris Kruse, Vladimir Aladinskiy, Yan Ivanenkov, Daniil Polykovskiy, Yanyun Fu, Eugene Babin, Junwen Qiao, Xing Liang, Zhenzhen Mou, Hui Wang, Frank W Pun, Pedro Torres-Ayuso, Alexander V

Author Correction: The kinase TNIK is an essential activator of Wnt target genes

作者更正:激酶TNIK是Wnt靶基因的重要激活因子。

Mahmoudi, Tokameh; Li, Vivian S W; Ng, Ser Sue; Taouatas, Nadia; Vries, Robert G J; Mohammed, Shabaz; Heck, Albert J; Clevers, Hans

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent.

人工智能驱动的机器人实验室发现,药物抑制 TNIK 是一种有效的类固醇制剂。

Mendelian randomization integrated with multi-omics analysis identifies TNIK as a key gene in gut microbiota-induced IBD development.

孟德尔随机化与多组学分析相结合,确定 TNIK 是肠道菌群诱导 IBD 发展的关键基因。

Transcriptome analysis to explore the mechanism of downregulated TNIK influencing the effect of risperidone

通过转录组分析探讨TNIK下调影响利培酮疗效的机制

Yuan, Ruixue; Li, Yaojing; Li, Xiangyi; Fu, Yingmei; Ning, Ailing; Wang, Dongxiang; Zhang, Ran; Yu, Shunying; Xu, Qingqing

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

突触后密度信号中枢 TNIK 的突变会破坏人类神经发育障碍模型中的 PSD 信号传导

Jianzhi Jiang, Brent Wilkinson, Ilse Flores, Nicolas Hartel, Simeon R Mihaylov, Veronica A Clementel, Helen R Flynn, Fowsan S Alkuraya, Sila Ultanir, Nicholas A Graham, Marcelo P Coba

The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

Traf2 和 NcK 相互作用激酶抑制剂 NCB-0846 可抑制与 GRIA1 减少有关的癫痫发作活动

Min Wang, Yixue Gu, Qiubo Li, Bangzhe Feng, Xinke Lv, Hao Zhang, Qingxia Kong, Zhifang Dong, Xin Tian, Yanke Zhang