TRAF2相关文献与解析，生知库 | 链接生命科学的每一步

Epstein-barr virus latent membrane protein 1 targets cIAP1, cIAP2 and TRAF2 for proteasomal degradation to activate the non-canonical NF-ÎºB pathway.

Epstein-barr 病毒潜伏膜蛋白 1 靶向 cIAP1、cIAP2 和 TRAF2 进行蛋白酶体降解，从而激活非经典 NF-κB 通路。

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1013898

Sun Yizhe, Li Shunji, Mitra Bidisha, Zhong Ling, Zhang Aretina, Gewurz Benjamin E

Genetic variants and serum biomarkers of CXCL8, MAP3K7, LTA/TNF, EXOC3L1, PROCR, and TRAF2 in Age-Related macular degeneration: associations with disease risk and therapeutic response

CXCL8、MAP3K7、LTA/TNF、EXOC3L1、PROCR 和 TRAF2 的基因变异和血清生物标志物在年龄相关性黄斑变性中的作用：与疾病风险和治疗反应的关联

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-42838-9

Cebatoriene, Dzastina; Vilkeviciute, Alvita; Duseikaite-Vidike, Monika; Pileckaite, Enrika; Bruzaite, Akvile; Kriauciuniene, Loresa; Zaliuniene, Dalia; Liutkeviciene, Rasa

The Impact of Targeting TRAF2 and NCK-Interacting Protein Kinase on Antitumor Effect and Tumor Immune Environment in c-MYC-High SCLC

靶向TRAF2和NCK相互作用蛋白激酶对c-MYC高表达小细胞肺癌抗肿瘤效应和肿瘤免疫微环境的影响

期刊:Journal of Thoracic Oncology

影响因子:20.8

doi:10.1016/j.jtho.2025.12.102

Tanimoto, Azusa; Ramkumar, Kavya; Stewart, C Allison; Zhang, Bingnan; Concannon, Kyle; Cardnell, Robert J; Shen, Li; Wang, Qi; Wang, Jing; Gay, Carl M; Byers, Lauren Averett

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion.

HSP47抑制通过TRAF2去泛素化诱导CD155表达，从而促进肿瘤免疫逃逸。

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-011976

Mou Haochen, Qu Hao, Chen Shixin, Zhang Wenkan, Chen Liang, Wang Zhuli, Eloy Yinwang, Shao Zhenxuan, Zhou Hao, Xue Yucheng, Sun Hangxiang, Wang Fangqian, Chai Xupeng, Zhang Jiahao, Yao Minjun, Zhao Shenzhi, Lei Jiangchu, Jin Lingxiao, Lu Senxu, Li Binghao, Wang Zenan, Ye Zhaoming

TRAF2 Promotes Liver Fibrosis via Regulation of the HIF-1Î±/GLUT1-Mediated Glycolysis in Hepatic Stellate Cells.

TRAF2 通过调节肝星状细胞中 HIF-1α/GLUT1 介导的糖酵解促进肝纤维化。

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.99682

Zhang Yina, Xu Siduo, Shao Jiajia, Lu Yining, Zhao Lingzhu, Liang Xue, Yao Jiping, Li Minwei, Liu Yanning, Zheng Min

Inflammation and cancer cell survival: TRAF2 as a key player

炎症与癌细胞存活：TRAF2 扮演关键角色

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-07609-w

Albini, Adriana; Di Paola, Luisa; Mei, Giampiero; Baci, Denisa; Fusco, Nicola; Corso, Giovanni; Noonan, Douglas

Immunology/Inflammation

细胞生物学

发表日期：2025

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USP1-TRAF2 axis-regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma

USP1-TRAF2轴调控的mortalin稳定性通过破坏外周T细胞淋巴瘤中的钙转运介导化疗耐药性

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2504195122

Gui, Ailing; Yan, Yichen; Jiang, Shiyu; Chen, Feng; Zhou, Xiaolong; Sun, Qi; Qiu, Shi; Wu, Jichuan; Li, Xiya; Zhang, Junyi; Liu, Jie; Zhu, Shun; Wang, Lan; Liu, Wen; Zuo, Ji; Zhang, Qunling; Yang, Ling

MYSM1 promotes lung adenocarcinoma progression via TRAF2/3-mediated activation of MAPK and non-canonical NF-ÎºB pathways.

MYSM1 通过 TRAF2/3 介导的 MAPK 和非经典 NF-κB 通路激活促进肺腺癌进展。

期刊:npj Precision Oncology

影响因子:8

doi:10.1038/s41698-025-01116-z

Yu Wenhao, Ma Luyuan, Li Rongyang, Zhu Dingqiang, Qu Chenghao, Han Jingyi, Tian Yu, Tian Hui, Liang Jinghui

Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma.

三级淋巴结构特征分析表明，CD40 和 STING 与 TRAF2 的竞争性结合驱动 IRF4 介导的 B 细胞活化，从而促进食管鳞状细胞癌的发生。

期刊:Cancer Gene Therapy

影响因子:5

doi:10.1038/s41417-025-00944-2

Zheng Yujia, Chen Donglai, Xu Yi, Xu Xuejun, Song Peidong, Wu Xuejie, Tan Lijie, Mao Yiming, Chen Yongbing

Correction: TRAF2 is a biologically important necroptosis suppressor

更正：TRAF2 是一种具有重要生物学意义的坏死性凋亡抑制因子

Epstein-barr virus latent membrane protein 1 targets cIAP1, cIAP2 and TRAF2 for proteasomal degradation to activate the non-canonical NF-ÎºB pathway.

Epstein-barr 病毒潜伏膜蛋白 1 靶向 cIAP1、cIAP2 和 TRAF2 进行蛋白酶体降解，从而激活非经典 NF-κB 通路。

Genetic variants and serum biomarkers of CXCL8, MAP3K7, LTA/TNF, EXOC3L1, PROCR, and TRAF2 in Age-Related macular degeneration: associations with disease risk and therapeutic response

CXCL8、MAP3K7、LTA/TNF、EXOC3L1、PROCR 和 TRAF2 的基因变异和血清生物标志物在年龄相关性黄斑变性中的作用：与疾病风险和治疗反应的关联

The Impact of Targeting TRAF2 and NCK-Interacting Protein Kinase on Antitumor Effect and Tumor Immune Environment in c-MYC-High SCLC

靶向TRAF2和NCK相互作用蛋白激酶对c-MYC高表达小细胞肺癌抗肿瘤效应和肿瘤免疫微环境的影响

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion.

HSP47抑制通过TRAF2去泛素化诱导CD155表达，从而促进肿瘤免疫逃逸。

TRAF2 Promotes Liver Fibrosis via Regulation of the HIF-1Î±/GLUT1-Mediated Glycolysis in Hepatic Stellate Cells.

TRAF2 通过调节肝星状细胞中 HIF-1α/GLUT1 介导的糖酵解促进肝纤维化。

Inflammation and cancer cell survival: TRAF2 as a key player

炎症与癌细胞存活：TRAF2 扮演关键角色

USP1-TRAF2 axis-regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma

USP1-TRAF2轴调控的mortalin稳定性通过破坏外周T细胞淋巴瘤中的钙转运介导化疗耐药性

MYSM1 promotes lung adenocarcinoma progression via TRAF2/3-mediated activation of MAPK and non-canonical NF-ÎºB pathways.

MYSM1 通过 TRAF2/3 介导的 MAPK 和非经典 NF-κB 通路激活促进肺腺癌进展。

Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma.

三级淋巴结构特征分析表明，CD40 和 STING 与 TRAF2 的竞争性结合驱动 IRF4 介导的 B 细胞活化，从而促进食管鳞状细胞癌的发生。