日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

p21(+)TREM2(+) senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

p21(+)TREM2(+)衰老巨噬细胞促进炎症衰老和代谢功能障碍相关的脂肪肝疾病。

Salladay-Perez, Ivan A; Avila, Itzetl; Estrada, Lizeth; Alexandru, Andreea C; Ponce, Cristian; Dhingra, Anika; Torres, Grasiela; Deng, Christina Y; Hegde, Ronak; Gensheimer, Julia; Kale, Abhijit; Heckenbach, Indra; Hui, Simon; Edillor, Chantle; Soto, Jose A; Napior, Alexander J; Little, Isaiah; Larsen, Mark; Rose, Jacob; Farahi, Lia; Lopez Gonzalez, Edwin D J; Krieger, Matthew R; Chowdhury, Kushan; Sharma, Mridul; Jiang, Yuming; Williams, Kevin; Scheibye-Knudsen, Morten; Koehler, Carla M; Meyer, Jesse G; Mack, Julia J; Brenner, Charles; Bensinger, Steven J; Lagger, Cyril; de Magalhães, João Pedro; Schilling, Birgit; Singh, Rajat; Verdin, Eric; Lusis, Aldons J; Covarrubias, Anthony J

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of TREM2-mediated microglial activation

硫脂缺乏诱导的星形胶质细胞增生和髓鞘脂质稳态失衡与TREM2介导的小胶质细胞活化无关。

He, Sijia; Mittra, Namrata; Bao, Hanmei; Bhattacharjee, Anindita; Dodds, Sherry G; Dupree, Jeffrey L; Han, Xianlin

Paclitaxel drives TREM2(+) macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel.

紫杉醇驱动 TREM2(+) 巨噬细胞扩增,导致其治疗效果不如 Nab-紫杉醇。

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function

TREM2-T96K 功能获得性突变通过损害小胶质细胞功能增加患阿尔茨海默病的风险。

Dominika J Pilat,Hoang Le,Dmitry Prokopenko,Chih-Chung Jerry Lin,William A Eimer,Luisa Quinti,Evan P Gavrilles,Sheyla N Garcia,Sara N Heitman

TREM2 Drives Neutrophil Extracellular Traps-Induced Dendritic Cell Maturation and Contributes to Lupus Progression

TREM2驱动中性粒细胞胞外陷阱诱导的树突状细胞成熟并促进狼疮进展

Shu, Jingxian; Liang, Jiabi; Zeng, Linda; Zhong, Shuping; Fang, Xueling; Xu, Yating; Wu, Yongjian; Huang, Xi

TREM2-Mediated Cholesterol Efflux in Macrophages Inhibits Anti-Tumor Immunity via Limitation of CD4(+) T and NK Cells.

巨噬细胞中 TREM2 介导的胆固醇外流通过限制 CD4(+) T 细胞和 NK 细胞抑制抗肿瘤免疫。

TREM2-expressing macrophages in liver diseases

肝脏疾病中表达TREM2的巨噬细胞

Wang, Xiaochen; Qiu, Zhiyu; Zhong, Zhenyu; Liang, Shuang

CAR-T triggers TAM reeducation and adaptive anti-tumor response via TREM2 deficiency or CD40 agonist.

CAR-T 通过 TREM2 缺陷或 CD40 激动剂触发 TAM 再教育和适应性抗肿瘤反应。

Liu Ting, Gao Huixin, Xi Zhihui, Yu TianTian, Gu Yimei, Mai Hanbing, Yuan Hui, Liu Yafang, Liu Haikuan, Zhang Qiaoxuan, Huang Xianzhang, Fan Wenzhe, Tan Jizhou

Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases.

合成的抗裂解TREM2可增强巨噬细胞吞噬作用,用于治疗炎症性疾病。