日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease

磷酸化tau蛋白丝氨酸262和丝氨酸356作为阿尔茨海默病中缠结前可溶性tau蛋白聚集体的生物标志物

Tohidul Islam # ,Emily Hill # ,Eric E Abrahamson # ,Stijn Servaes ,Denis S Smirnov ,Xuemei Zeng ,Anuradha Sehrawat ,Yijun Chen ,Przemysław R Kac ,Hlin Kvartsberg ,Maria Olsson ,Emma Sjons ,Fernando Gonzalez-Ortiz ,Joseph Therriault ,Cécile Tissot ,Ivana Del Popolo ,Nesrine Rahmouni ,Abbie Richardson ,Victoria Mitchell ,Henrik Zetterberg ,Tharick A Pascoal ,Tammaryn Lashley ,Mark J Wall ,Douglas Galasko ,Pedro Rosa-Neto ,Milos D Ikonomovic ,Kaj Blennow ,Thomas K Karikari

Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss

Tau蛋白是一种对糖皮质激素亲和力较低的受体,是糖皮质激素诱导的骨丢失所必需的。

Wenyu Fu #,Meng Chen #,Kaidi Wang #,Yujianan Chen,Yazhou Cui,Yangli Xie,Zi-Ning Lei,Wenhuo Hu,Guodong Sun,Guiwu Huang,Chaopeng He,Jackie Fretz,Aubryanna Hettinghouse,Ronghan Liu,Xianyi Cai,Mingshuang Zhang,Yuehong Chen,Nan Jiang,Minchun He,Daniel H Wiznia,Huiyun Xu,Zhe-Sheng Chen,Lin Chen,Kanglai Tang,Hong Zhou,Chuan-Ju Liu

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

体内tau蛋白过度磷酸化与突触丢失和行为异常有关,即使不存在tau蛋白种子。

Naoto Watamura #,Martha S Foiani #,Sumi Bez,Mathieu Bourdenx,Alessia Santambrogio,Claire Frodsham,Elena Camporesi,Gunnar Brinkmalm,Henrik Zetterberg,Saisha Patel,Naoko Kamano,Mika Takahashi,Javier Rueda-Carrasco,Loukia Katsouri,Stephanie Fowler,Emir Turkes,Shoko Hashimoto,Hiroki Sasaguri,Takashi Saito,Afm Saiful Islam,Seico Benner,Toshihiro Endo,Katsuji Kobayashi,Chiho Ishida,Michele Vendruscolo,Masahito Yamada,Karen E Duff,Takaomi C Saido

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice

DAP12 缺失可减少雌性 tau 蛋白病小鼠的神经元 SLIT2 表达和脱髓鞘,并增强其大脑的恢复能力。

Hao Chen ,Li Fan ,Qi Guo ,Man Ying Wong ,Jingjie Zhu ,Nessa Foxe ,Winston Wang ,Aviram Nessim ,Gillian Carling ,Bangyan Liu ,Chloe Lopez-Lee ,Yige Huang ,Sadaf Amin ,Tark Patel ,Sue-Ann Mok ,Won-Min Song ,Bin Zhang ,Shiaoching Gong ,Qin Ma ,Hongjun Fu ,Li Gan ,Wenjie Luo

Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer's Disease

中脑退化会引发实验性阿尔茨海默病中的星形胶质细胞反应性和tau蛋白病理。

Livia La Barbera # ,Paraskevi Krashia # ,Gilda Loffredo # ,Emma Cauzzi ,Maria Luisa De Paolis ,Martina Montanari ,Luana Saba ,Elena Spoleti ,Serena Ficchì ,Claudio Zaccone ,Marco De Bardi ,Claudia Palazzo ,Ramona Marino ,Emanuele Claudio Latagliata ,Stefano Puglisi-Allegra ,Giovanna Borsellino ,Flavio Keller ,Luisa Lo Iacono ,Maria Teresa Viscomi ,Annalisa Nobili # ,Marcello D'Amelio #

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies

索拉非尼通过促进E3泛素连接酶FBXW7的活性来增加tau蛋白的降解,从而改善tau蛋白病。

Yunqiang Zhou ,Yong Wang ,Huiying Yang ,Chi Zhang ,Jian Meng ,Lingliang Zhang ,Kun Li ,Ling-Ling Huang ,Xian Zhang ,Hong Luo ,Yunwu Zhang

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency

种子结构和绒毛状外壳中的磷酸化影响tau蛋白的播种能力

Alysa Kasen ,Sofia Lövestam ,Libby Breton ,Lindsay Meyerdirk ,Jacob Alec McPhail ,Kristin Piche ,Ariel Louwrier ,Colt D Capan ,Hyoungjoo Lee ,Sjors H W Scheres ,Michael X Henderson

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq

全生物体snRNA测序揭示Aβ42和Tau蛋白不同的系统性影响

Ye-Jin Park ,Tzu-Chiao Lu ,Tyler Jackson ,Lindsey D Goodman ,Lindsey Ran ,Jiaye Chen ,Chung-Yi Liang ,Erin Harrison ,Christina Ko ,Xi Chen ,Baiping Wang ,Ao-Lin Hsu ,Elizabeth Ochoa ,Kevin F Bieniek ,Shinya Yamamoto ,Yi Zhu ,Hui Zheng ,Yanyan Qi ,Hugo J Bellen ,Hongjie Li

Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer's disease

突触丢失模式受大脑连接组的限制,并在阿尔茨海默病中受磷酸化tau蛋白的调节。

Ying Luan # ,Weiyi Wang # ,Qi Huang # ,Yan Wang ,Jana Nussbaumer ,Jie Wang ,Anna Steward ,Sebastian N Roemer-Cassiano ,Yihui Guan ,Michael Ewers ,Michael Schöll ,Ruiqing Ni ,Binyin Li ,Nicolai Franzmeier ,Fang Xie

Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation

聚丝氨酸介导的FAF2/UBXD8靶向作用可改善tau蛋白聚集

Meaghan Van Alstyne,Georgia Brown,Vanessa L Nguyen,Mani Ramaswami,Charles A Hoeffer,Roy Parker