Trk相关文献与解析，生知库 | 链接生命科学的每一步

Zhang Yunpei, Tan Cheng, Liu Ziyi, Mao Xiangdi, Jiang Cheng, Mohammed Afzaal Nadeem, Li Xiaolei, Lu Renzhong, Wang Anmin, Maihemuti Wusiman, Pek Nicole, Fu Hailu, Milbes Omar, Pandrangi Kavya, Johnson Colin Patrick, Sekar Varun, Liu Yaping, Lai Li, Pryhuber Gloria S, Kalinichenko Vladimir V, Miao Yifei, Guo Minzhe, Gu Mingxia

心血管

Trk

NTRK2

发表日期：2026

文献求助收藏

Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1Î±-mediated mitochondrial dysfunction to senescence and ferroptosis.

三氯生通过 Nur77 泛素化加剧心肌梗死后损伤：将 NTRK2/PGC-1α 介导的线粒体功能障碍与衰老和铁死亡联系起来。

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2026.104022

Retraction Note: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

撤稿声明：NT-4 通过 TrkB/PI3K/FoxO1 通路减轻新生大鼠生发基质出血后的神经炎症

期刊:Journal of Neuroinflammation

影响因子:10.1

doi:10.1186/s12974-025-03681-3

Wang, Tianyi; Zhang, Junyi; Li, Peng; Ding, Yan; Tang, Jiping; Chen, Gang; Zhang, John H

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons.

唐氏综合征基底前脑神经元中 BDNF-TrkB 运输和信号传导受损。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08464-z

Blackburn Emily, Birsa Nicol, Lopes AndrÃ© Teixeira, Fisher Elizabeth M C, Lazo Oscar M, Schiavo Giampietro

Trk1 potassium transport is crucial for effective Candidozyma auris skin colonization

Trk1钾离子转运对于耳念珠菌有效定植皮肤至关重要。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2602824123

Glawe, Adam J; Eix, Emily F; Johnson, Chad J; Zarnowski, Robert; Andes, Maisy K; Lazarcik, James; Henzler-Wildman, Katherine A; Nett, Jeniel E

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway

MYCN通过破坏PKA信号通路抑制神经母细胞瘤细胞中TrkC介导的分化。

期刊:Cell Death Discovery

影响因子:7

doi:10.1038/s41420-026-03024-y

Maher, Stephanie; Roe, Andrew; Wynne, Kieran; Zhernovkov, Vadim; Halasz, Melinda

BIN1 Interacts with Tau Fragments to Inhibit TrkB Signaling Endosome Recycling in a Mouse Model of Alzheimer's Disease.

在阿尔茨海默病小鼠模型中，BIN1 与 Tau 片段相互作用以抑制 TrkB 信号内体回收。

期刊:Neuroscience Bulletin

影响因子:5.8

doi:10.1007/s12264-025-01435-y

Wei Yanuo, Xi Ye, Li Hui, Zhang Xingxing, Wang Yu, Li Yunpeng, Fang Ronghao, Xiang Jie, Wu Shengxi

TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells

TrkA激活维持了耐化疗髓母细胞瘤细胞的化疗耐药性。

期刊:Acta Neuropathologica Communications

影响因子:5.7

doi:10.1186/s40478-026-02265-3

Manfreda, Lorenzo; Bortolozzi, Roberta; Mao, Diletta; Mariotto, Elena; Viola, Giampietro; Persano, Luca; Rampazzo, Elena

Neurodegeneration, Oxidative Stress, NGF/TrkA/P75(NTR), and PGE2 Dysregulation Induced by PFOS Single and Repeated Treatment: Partial Protection by T3 and Other Therapeutic Approaches.

PFOS 单次和重复治疗引起的神经退行性变、氧化应激、NGF/TrkA/P75(NTR) 和 PGE2 失调：T3 和其他治疗方法的部分保护作用。

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics18030292

Moyano Paula, Flores Andrea, Sanjuan Javier, Plaza JosÃ© Carlos, Guerra-MenÃ©ndez LucÃa, Naval MarÃa Victoria, Abascal Luisa, Mateo-Sierra Olga, Del Pino Javier

Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation.

低强度脉冲超声通过抑制小胶质细胞 P2X4R 和激活 BDNF/TrkB 通路缓解 LPS 诱导的抑郁样行为。

期刊:CNS Neuroscience & Therapeutics

影响因子:5

doi:10.1002/cns.70786

Wang Yuanli, Meng Xinyue, Zhang Xinyi, Chen Ruilin, Zhang Mianzhi, Yang Deli, Zou Wanke, Chu Paul K, Ding Chengbiao, Zhan Hongrui

Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasia.

NTRK2 同工型的重新平衡可促进支气管肺发育不良中的血管再生。

Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1Î±-mediated mitochondrial dysfunction to senescence and ferroptosis.

三氯生通过 Nur77 泛素化加剧心肌梗死后损伤：将 NTRK2/PGC-1α 介导的线粒体功能障碍与衰老和铁死亡联系起来。

Retraction Note: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

撤稿声明：NT-4 通过 TrkB/PI3K/FoxO1 通路减轻新生大鼠生发基质出血后的神经炎症

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons.

唐氏综合征基底前脑神经元中 BDNF-TrkB 运输和信号传导受损。

Trk1 potassium transport is crucial for effective Candidozyma auris skin colonization

Trk1钾离子转运对于耳念珠菌有效定植皮肤至关重要。

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway

MYCN通过破坏PKA信号通路抑制神经母细胞瘤细胞中TrkC介导的分化。

BIN1 Interacts with Tau Fragments to Inhibit TrkB Signaling Endosome Recycling in a Mouse Model of Alzheimer's Disease.

在阿尔茨海默病小鼠模型中，BIN1 与 Tau 片段相互作用以抑制 TrkB 信号内体回收。

TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells

TrkA激活维持了耐化疗髓母细胞瘤细胞的化疗耐药性。

Neurodegeneration, Oxidative Stress, NGF/TrkA/P75(NTR), and PGE2 Dysregulation Induced by PFOS Single and Repeated Treatment: Partial Protection by T3 and Other Therapeutic Approaches.

PFOS 单次和重复治疗引起的神经退行性变、氧化应激、NGF/TrkA/P75(NTR) 和 PGE2 失调：T3 和其他治疗方法的部分保护作用。

Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation.

低强度脉冲超声通过抑制小胶质细胞 P2X4R 和激活 BDNF/TrkB 通路缓解 LPS 诱导的抑郁样行为。