日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration

UBQLN2 将蛋白质毒性与神经退行性疾病中的脂质代谢联系起来

Liu, Yang; Huang, Zhiyuan; Hsu, Yu-Wen; Deme, Pragney; Frankenfield, Ashley M; Wu, Suheng; Zhao, Xiaofeng; Liu, Honghe; Zhang, Tao; Alexander, Elizabeth J; Liu, Mingming; Zhang, Yanjun; Wang, Haocheng; Zhou, Yixin; Monteiro, Mervyn J; Hao, Ling; Haughey, Norman J; Wang, Jiou

TRIM9 and TRIM26 Interact with UBQLN2(P497H) to Modulate Its Proteasomal Degradation

TRIM9 和 TRIM26 与 UBQLN2(P497H) 相互作用以调节其蛋白酶体降解

Chen, Xingyuan; Cao, Zhongwen; Liang, Xiaochen; Zhao, Ting; Wang, Yinsheng

TRIM32-UBQLN2-p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates

TRIM32-UBQLN2-p62轴通过穿梭凝聚体促进TDP-43包涵体形成和淀粉样蛋白聚集。

He, Ziyan; Zhou, Jiechao; Zhang, Rongzhen; Meng, Fei; Nauen, David W; Troncoso, Juan C; Worley, Paul F; Zhang, Wenchi

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential

UBQLN2在神经退行性疾病中的作用:机制解析及新兴治疗潜力

Matthews, Autumn M; Whiteley, Alexandra M

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD.

相互作用组筛选表明 BAG6 是 ALS/FTD 中 UBQLN2 错误折叠的抑制因子。

Kim Sang Hwa, Boos Claire E, Scalf Mark, Wilkemeyer Akasha K, Smith Lloyd M, Tibbetts Randal S

UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10

UBQLN2 是 UBE3A 介导的蛋白酶体降解驯化逆转录元件 PEG10 所必需的。

Roberts, Julia E; Huynh, Phuoc T; Carale, Luis O; Whiteley, Alexandra M

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia

相互作用组筛选表明,BAG6是ALS痴呆症中UBQLN2错误折叠的抑制因子。

Kim, Sang Hwa; Boos, Claire E; Scalf, Mark; Wilkemeyer, Akasha K; Smith, Lloyd M; Tibbetts, Randal S

E3 ligase recruitment by UBQLN2 protects substrates from proteasomal degradation.

UBQLN2 募集 E3 连接酶可保护底物免受蛋白酶体降解。

Scheutzow Ashley N, Thanthirige Sachini, Siffer Gracie, Sorkin Alexander D, Wohlever Matthew L

Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia

UBQLN2 p.T487I 相关的肌萎缩侧索硬化症和额颞叶痴呆患者中泛素 2 和 TDP-43 聚集体在中枢神经系统中的分布

Laura R Nementzik, Kyrah M Thumbadoo, Helen C Murray, David Gordon, Shu Yang, Ian P Blair, Clinton Turner, Richard L M Faull, Maurice A Curtis, Catriona McLean, Garth A Nicholson, Molly E V Swanson, Emma L Scotter

Chronic Oxidative Stress and Stress Granule Formation in UBQLN2 ALS Neurons: Insights into Neuronal Degeneration and Potential Therapeutic Targets

UBQLN2 ALS神经元中的慢性氧化应激和应激颗粒形成:对神经元退化和潜在治疗靶点的见解

Ao Gu ,Yiti Zhang ,Jianfeng He ,Mingri Zhao ,Lingjie Ding ,Wanxi Liu ,Jianing Xiao ,Jiali Huang ,Mujun Liu ,Xionghao Liu