UBR2相关文献与解析，生知库 | 链接生命科学的每一步

The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy

UBR2在三阴性乳腺癌中的作用及其对免疫检查点阻断疗法的意义

期刊:Discover Oncology

影响因子:2.8

doi:10.1007/s12672-025-03153-3

Yanlin Jiang #,Yi Fu #,Xinyan Song,Yongjie Xie,Xiaobin Shang,Xi Liang

The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling

磷酸酶DUSP22抑制UBR2介导的K63泛素化和TCR信号下游Lck的激活。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-44843-w

Ying-Chun Shih ，Hsueh-Fen Chen ，Chia-Ying Wu ，Yi-Ru Ciou ，Chia-Wen Wang ，Huai-Chia Chuang ，Tse-Hua Tan

UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

UBR2靶向肌球蛋白重链IIb和IIx进行降解：癌症诱导肌肉萎缩的关键分子机制

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2200215119

Gao, Song; Zhang, Guohua; Zhang, Zicheng; Zhu, James Z; Li, Li; Zhou, Yong; Rodney, George G Jr; Abo-Zahrah, Reem S; Anderson, Lindsey; Garcia, Jose M; Kwon, Yong Tae; Li, Yi-Ping

Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells

蛋白质组动力学分析揭示了SDE2和缺氧在前列腺癌细胞DNA损伤反应中的功能作用

期刊:NAR Cancer

影响因子:3.4

doi:10.1093/narcan/zcaa010

Ang Luo ,Yao Gong ,Hyungjin Kim ,Yue Chen

Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase

磷酸化影响 BMX 激酶蛋白水解活化形式的 N 端规则降解

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M116.737387

Mohamed A Eldeeb, Richard P Fahlman

The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

蛋白水解产生的抗凋亡酪氨酸激酶 Lyn 通过 N 端规则通路降解

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.1931

Mohamed A Eldeeb, Richard P Fahlman

Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2

肿瘤细胞诱导E3泛素连接酶UBR2上调的信号传导机制

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.12-222711

Zhang, Guohua; Lin, Ren-Kuo; Kwon, Yong Tae; Li, Yi-Ping

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

UBR2通过组蛋白泛素化介导精子发生过程中的转录沉默。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.0910267107

An, Jee Young; Kim, Eun-A; Jiang, Yonghua; Zakrzewska, Adriana; Kim, Dong Eun; Lee, Min Jae; Mook-Jung, Inhee; Zhang, Yi; Kwon, Yong Tae

An alternative pocket for binding the N-degrons by the UBR1 and UBR2 ubiquitin E3 ligases

UBR1和UBR2泛素E3连接酶结合N-降解子的另一种口袋

The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy

UBR2在三阴性乳腺癌中的作用及其对免疫检查点阻断疗法的意义

The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling

磷酸酶DUSP22抑制UBR2介导的K63泛素化和TCR信号下游Lck的激活。

UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

UBR2靶向肌球蛋白重链IIb和IIx进行降解：癌症诱导肌肉萎缩的关键分子机制

Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells

蛋白质组动力学分析揭示了SDE2和缺氧在前列腺癌细胞DNA损伤反应中的功能作用

Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase

磷酸化影响 BMX 激酶蛋白水解活化形式的 N 端规则降解

The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway

蛋白水解产生的抗凋亡酪氨酸激酶 Lyn 通过 N 端规则通路降解

Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2

肿瘤细胞诱导E3泛素连接酶UBR2上调的信号传导机制

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

UBR2通过组蛋白泛素化介导精子发生过程中的转录沉默。