USP28相关文献与解析，生知库 | 链接生命科学的每一步

Suanes-Cobos, Lucía; Aguilera-Ventura, Irene; Torres-Ramos, Miguel; Serrano-Yubero, Alejandra; Moreno Fernández-Aliseda, Claudia; Fernández, Silvia; Garrido-Rodríguez, Martín; de la Luna, Susana; Prieto-Garcia, Cristian; Diefenbacher, Markus E; Mejías-Pérez, Ernesto; Calzado, Marco A

肿瘤

DYR

肿瘤免疫

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1.

USP28 通过去泛素化和稳定 SIRT1 促进 H1975 非小细胞肺癌细胞对奥希替尼产生耐药性。

期刊:Kaohsiung Journal of Medical Sciences

影响因子:3.1

doi:10.1002/kjm2.70095

Fan Hu-Sen, Li Xiu-Mei, Gu Jia-Qi, Wang Hai-Feng, Zhang Zhen-Jiang

Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 Pathway

53BP1-USP28-p53通路保障有丝分裂的一致性，从而维护细胞的保真度。

期刊:

影响因子:

doi:10.64898/2026.03.16.712228

Shulman, Avital; Ozaki, Kanako; Chang, Lukas R; Hoong, Eden; Bryan Tsou, Meng-Fu

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization.

与癌症相关的 USP28 错义突变会破坏 53BP1 相互作用和 p53 稳定性。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-66341-3

Belal Hazrat, Ng Esther Feng Ying, Ohta Midori, Meitinger Franz

USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment

基于USP28的去泛素化酶靶向嵌合体用于癌症治疗

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.5c01889

Wang, Zhen; Qian, Chao; Xiong, Yan; Zhang, Dingpeng; Inuzuka, Hiroyuki; Zhong, Yue; Xie, Ling; Chen, Xian; Jin, Jian; Wei, Wenyi

NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

NOTCH1信号通路因del(11q)缺失导致去泛素化酶USP28丢失而失调，提示USP28抑制剂可能是慢性淋巴细胞白血病(CLL)的一种新型治疗靶点。

期刊:Leukemia

影响因子:13.4

doi:10.1038/s41375-025-02632-4

Ehrmann, Alena Sophie; Quijada-Álamo, Miguel; Close, Viola; Guo, Min; Carracoi, Valentina; Pérez-Carretero, Claudia; Corchete, Luis Antonio; Friedrich, Tobias; Giaimo, Benedetto Daniele; Yosifov, Deyan Yordanov; Bloehdorn, Johannes; Rodríguez-Sánchez, Alberto; Tausch, Eugen; Schneider, Christof; Döhner, Hartmut; Kietzmann, Thomas; Borggrefe, Tilman; Stilgenbauer, Stephan; Oswald, Franz; Hernández-Rivas, Jesús-María; Mertens, Daniel

The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma

去泛素化酶USP28维持PPARγ的表达，其失活可保护小鼠免受饮食诱导的MASH和肝癌的侵害。

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.01.046

Cai, Changzhou; Luo, Hangqi; Peng, Jin; Zhen, Xinghua; Shen, Xiang; Xi, Xiaomei; Zhu, Jianrong; Fang, Yanfei; Chen, Xiaoli; Wang, Jiewei; Yu, Chaohui; Zhang, Pumin; Xu, Chengfu

USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer

USP28通过增强卵巢癌中SOX9介导的DNA损伤修复来促进PARP抑制剂耐药性

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-025-07647-4

Pharmacologic interrogation of USP28 cellular function in p53 signaling

通过药理学方法研究USP28在p53信号通路中的细胞功能

期刊:Cell Chemical Biology

影响因子:7.2

doi:10.1016/j.chembiol.2025.08.002

Bratt, Ariana S; Kilgas, Susan; Tarazona Guzman, Maria I; Magin, Robert S; Jaen Maisonet, Isabella; Starnbach, Cara A; Teh, Wei Pin; Varca, Anthony C; Hu, Bin; Tarazona Guzman, Esteban; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Girardi, Nicholas M; Adelmant, Guillaume; Marto, Jarrod A; Chowdhury, Dipanjan; Buhrlage, Sara J

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

E3泛素连接酶DTX3L和去泛素化酶USP28通过相互调节其蛋白水平来精细调控DNA修复。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2025.112990

Daniela Mennerich ，Yashwanth Ashok ，Carlos Vela-Rodríguez ，Heli I Hentilä ，Melanie Rall-Scharpf ，Lisa Wiesmüller ，Renata Prunskaite-Hyyryläinen ，Lari Lehtiö ，Thomas Kietzmann

A novel feedback loop between DYRK2 and USP28 regulates cancer homeostasis and DNA damage signaling

DYRK2 和 USP28 之间一种新型的反馈回路调节癌症稳态和 DNA 损伤信号传导

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1.

USP28 通过去泛素化和稳定 SIRT1 促进 H1975 非小细胞肺癌细胞对奥希替尼产生耐药性。

Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 Pathway

53BP1-USP28-p53通路保障有丝分裂的一致性，从而维护细胞的保真度。

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization.

与癌症相关的 USP28 错义突变会破坏 53BP1 相互作用和 p53 稳定性。

USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment

基于USP28的去泛素化酶靶向嵌合体用于癌症治疗

NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

NOTCH1信号通路因del(11q)缺失导致去泛素化酶USP28丢失而失调，提示USP28抑制剂可能是慢性淋巴细胞白血病(CLL)的一种新型治疗靶点。

The deubiquitinase USP28 maintains the expression of PPARγ and its inactivation protects mice from diet-induced MASH and hepatocarcinoma

去泛素化酶USP28维持PPARγ的表达，其失活可保护小鼠免受饮食诱导的MASH和肝癌的侵害。

USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer

USP28通过增强卵巢癌中SOX9介导的DNA损伤修复来促进PARP抑制剂耐药性

Pharmacologic interrogation of USP28 cellular function in p53 signaling

通过药理学方法研究USP28在p53信号通路中的细胞功能

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

E3泛素连接酶DTX3L和去泛素化酶USP28通过相互调节其蛋白水平来精细调控DNA修复。