VCP相关文献与解析，生知库 | 链接生命科学的每一步

Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

膜蛋白组装 MAN1B1-VCP 复合物，将内质网中的外源糖蛋白靶向溶酶体进行降解。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202519256

Zhang Jing, Lu Xiaoran, Li Sunan, Wang Tao, Ahmad Iqbal, Zheng Yong-Hui

VCP

发表日期：2026

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Proximity proteomics reveals OTUD6B regulation of stress granule dynamics through coalescence with VCP/p97.

邻近蛋白质组学揭示了 OTUD6B 通过与 VCP/p97 融合来调控应激颗粒动态。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08451-4

Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study

VCP抑制剂ML240在大动物和人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究

期刊:BMC Medicine

影响因子:8.3

doi:10.1186/s12916-025-04610-0

Almansa-García, Ana-Cristina; Armento, Angela; Cao, Bowen; Petremann-Dumé, Anne-Sophie; Salmaso, Stefano; Caliceti, Paolo; Henes, Cristine; Bolz, Sylvie; Kilger, Ellen; Süsskind, Daniela; Ueffing, Marius; Arango-Gonzalez, Blanca

VCP

发表日期：2026

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Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes

缺氧应激是人类VCP突变型ALS星形胶质细胞的早期致病事件。

期刊:Stem Cell Reports

影响因子:5.1

doi:10.1016/j.stemcr.2025.102723

Franklin, Hannah D; Crerar, Hamish; Parnandi, Nishita; Lattke, Michael; Majewski, Stanislaw; Clarke, Benjamin E; Pallikonda, Husayn; Howell, Michael; Boulton, Simon J; Patani, Rickie

Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.

V8 靶向 VCP 可通过形成聚集体和破坏线粒体自噬通量来抑制胶质母细胞瘤的发展。

期刊:Cellular Oncology

影响因子:4.8

doi:10.1007/s13402-025-01149-3

Retraction: Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery

撤稿：VCP疾病诱导的多能干细胞的肌源性分化：一种新型药物发现平台

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0347383

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

空泡性tau蛋白病相关突变D395G赋予p97/VCP氧化还原敏感性

期刊:

影响因子:

doi:10.64898/2026.04.16.718620

Rout, Smruti R; Kulke, Martin; Droemer, Maxim A; Wendel, Marcel; Cheng, Tat Cheung; Mauck, Tristan A; Asgari, Sean; Nemec, Antonia A; Shein, Mikhail; Sato, Yusuke; Fukai, Shuya; Witte, Gregor; Tomko, Robert J; Stengel, Florian; Zacharias, Martin; Schuetz, Anne K; Sakata, Eri

VCP

发表日期：2026

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TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins

TMEM259/MEMBRALIN 是一种非经典的内质网自噬受体，它与 MAN1B1 和 VCP 结合，从而清除病毒糖蛋白。

期刊:Autophagy Reports

影响因子:

doi:10.1080/27694127.2026.2639256

Camilleri, Jim Maurice; Zhang, Jing; Wang, Tao; Ahmad, Iqbal; Li, Sunan; Zheng, Yong-Hui

VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment

VCP下游代谢产物甘油-3-磷酸（G3P）抑制HCC微环境中CD8+T细胞的功能

期刊:Signal Transduction and Targeted Therapy

影响因子:40.8

doi:10.1038/s41392-024-02120-8

Cheng Cheng # ，Qingrui Zha # ，Linmao Sun # ，Tianming Cui # ，Xinyu Guo ，Changjian Xing ，Zhengxiang Chen ，Changyong Ji ，Shuhang Liang ，Shengwei Tao ，Junhui Chu ，Chenghui Wu ，Qi Chu ，Xuetian Gu ，Ning Zhang ，Yumin Fu ，Shumin Deng ，Yitong Zhu ，Jiabei Wang ，Yao Liu ，Lianxin Liu

Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease

异常的核孔复合体降解导致VCP疾病中的神经退行性变。

Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

膜蛋白组装 MAN1B1-VCP 复合物，将内质网中的外源糖蛋白靶向溶酶体进行降解。

Proximity proteomics reveals OTUD6B regulation of stress granule dynamics through coalescence with VCP/p97.

邻近蛋白质组学揭示了 OTUD6B 通过与 VCP/p97 融合来调控应激颗粒动态。

Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study

VCP抑制剂ML240在大动物和人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究

Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes

缺氧应激是人类VCP突变型ALS星形胶质细胞的早期致病事件。

Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.

V8 靶向 VCP 可通过形成聚集体和破坏线粒体自噬通量来抑制胶质母细胞瘤的发展。

Retraction: Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery

撤稿：VCP疾病诱导的多能干细胞的肌源性分化：一种新型药物发现平台

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

空泡性tau蛋白病相关突变D395G赋予p97/VCP氧化还原敏感性

TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins

TMEM259/MEMBRALIN 是一种非经典的内质网自噬受体，它与 MAN1B1 和 VCP 结合，从而清除病毒糖蛋白。

VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment

VCP下游代谢产物甘油-3-磷酸（G3P）抑制HCC微环境中CD8+T细胞的功能