日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

通过基于片段的抑制剂先导化合物发现,展现了WRN结构的灵活性

Palte, Rachel L; Mandal, Mihir; Sikorska, Justyna; Villafania, Artjohn B; Rickard, Meredith M; Bauer, Robert J; Buevich, Alexei V; Chai, Xiaomei; He, Jiafang; Hussain, Zahid; Koglin, Markus; MacDonald, Hannah B; Mansueto, My S; Maskos, Klaus; Methot, Joey L; Robustelli, Jaclyn; Soriano, Aileen; Tauchert, Marcel J; Tyagarajan, Sriram; Zhang, Minjia; Klein, Daniel J; Hicks, Jacqueline D; McLaren, David G; Gabelli, Sandra B; Wyss, Daniel F

Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery

对WRN解旋酶的结构解析揭示了其构象状态,并为MSI-H癌症药物研发提供了契机。

Fletcher, Catherine T; Mornement, Abigail A; Barrett, Charlotte; Canning, Peter; Rucktooa, Prakash; Huber, Sophie; Cooper, Christopher D O; Scully, Conor C G; Doré, Andrew S; Rohle, Daniel; Smith, Geoffrey M T; Skerratt, Sarah E; Kennedy, Amanda J

Novel Homozygous Variants in CIDEC and WRN in a Young Female with Lipodystrophy and Thyroid Cancer

一名患有脂肪营养不良和甲状腺癌的年轻女性的CIDEC和WRN基因中存在新的纯合变异

Patni, Nivedita; Xing, Chao; Huang, Chun-Yuan; Brown, Rebecca J; Garg, Abhimanyu

Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK Properties

发现并进行临床前评估高效、选择性强、具有改进药代动力学特性的变构共价WRN抑制剂

Xu, Zhaobing; Xiao, Qi; Liu, Yong; Jiang, Wen; Liu, Lifei; Sun, Hongna; Yang, Xiulan; Lu, Zhuojian; Yan, Bocheng; Long, Hanxiong; Zhang, Xuejun

Novel Werner Syndrome RecQ DNA Helicase (WRN) Inhibitors for Cancer Treatment

用于癌症治疗的新型沃纳综合征 RecQ DNA 解旋酶 (WRN) 抑制剂

Zhou, Xin; Liang, Steven H

The bacterial MRE11-RAD50 and DNA2-WRN homologs process replication forks at distinct and separate loci on the chromosome

细菌 MRE11-RAD50 和 DNA2-WRN 同源物在染色体上不同的位点处理复制叉。

Spolek, Raymond L; Christian, Paden Y H; Courcelle, Charmain T; Courcelle, Justin

Pan-Cancer Analysis of WRN: From Multi-Omics Biomarker Discovery to Therapy-Guiding Functional Evidence

WRN的泛癌分析:从多组学生物标志物发现到指导治疗的功能证据

Yao, Qing-Qing; Qi, Yue; Shi, Pei-Qin; Yang, Zi-Ye; Qu, Pengpeng; Zhang, Wen-Wen

Silk Scaffold Crypt-Villus Geometry Combined With L-WRN Feeder Cells Sustains Spatially Organized Epithelial Proliferation and Multilineage Differentiation

丝素蛋白支架隐窝绒毛几何结构与L-WRN饲养细胞相结合,可维持空间有序的上皮细胞增殖和多系分化。

Rudolph, Sara E; Longo, Brooke N; Chen, Ying; Kaplan, David L

Long non-coding RNA PWRN4 associated with post-SVR hepatocellular carcinoma: a genome-wide association study

长链非编码RNA PWRN4与SVR后肝细胞癌相关:一项全基因组关联研究

Suda, Goki; Sugiyama, Masaya; Hikita, Hayato; Nishio, Akira; Tatsumi, Tomohide; Takehara, Tetsuo; Murakawa, Miyako; Nakagawa, Mina; Asahina, Yasuhiro; Mizokami, Masashi; Kakisaka, Tatsuhiko; Sakamoto, Yuzuru; Taketomi, Akinobu; Miyanishi, Koji; Ueno, Yoshiyuki; Haga, Hiroaki; Maekawa, Shinya; Enomoto, Nobuyuki; Kurosaki, Masayuki; Kohjima, Motoyuki; Nakamuta, Makoto; Tanaka, Yasuhito; Yamamoto, Yoshiya; Baba, Masaru; Hanamatsu, Hisatoshi; Furukawa, Jun-Ichi; Ohara, Masatsugu; Kitagataya, Takashi; Kawagishi, Naoki; Nakai, Masato; Sho, Takuya; Ogawa, Koji; Sakamoto, Naoya

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers

鉴定出VVD-214/RO7589831,一种用于治疗MSI-High癌症的临床阶段共价变构WRN解旋酶抑制剂

Kikuchi, Shota; Green, Jason C; Rogness, Don C; Lam, Betty; Owyang, Zachary A; Malmstrom, Robert D; Tabatabaei, Ali; Snead, Aaron N; Hoffman, Melissa A; Bernard, Steffen M; Ashby, Paige; Lamb, Kelsey N; Horning, Benjamin D; Baltgalvis, Kristen A; Symons, Kent T; Glaza, Thomas A; Wu, Chu-Chiao; Song, Xiaodan; Pastuszka, Martha K; Sigler, John J; Pollock, Jonathan; Burgess, Laurence; Simon, Gabriel M; Patricelli, Matthew P; Weinstein, David S