YY1相关文献与解析，生知库 | 链接生命科学的每一步

Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8(+) T-Cell-Driven Cancer Cell Pyroptosis.

靶向 Notch1-YY1-ICAM1 信号轴可激活 CD8(+) T 细胞驱动的癌细胞焦亡，从而增强免疫疗法在 HCC 中的疗效。

doi:10.1002/advs.202512845

Zhu Ke, Zhang Fa-Peng, Qin Chao, Song Zhi-Xiao, Yang Cai-Ni, Lin Shu-Sheng, Yu Xian-Huan, Wu Wen-Rui, Liu Chao-Qun, Liu Chao, Xu Lei-Bo

YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy

YY1硝化通过抑制ANXA3诱导的微脂自噬参与DbCM心肌细胞脂毒性

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2026.104085

Chai, Jiayin; Han, Lijie; Mo, Degang; Bai, Yunfei; Yang, Yiming; Ding, Yuqing; Chen, Shuai; Kong, Xiangning; Zhu, Xinyu; Xu, Lijia; Dai, Hongyan; Wang, Wen

Polystyrene nanoplastics-induced lung epithelial cells ferroptosis promotes pulmonary fibrosis via YY1/FTL axis.

聚苯乙烯纳米塑料诱导的肺上皮细胞铁死亡通过 YY1/FTL 轴促进肺纤维化。

期刊:Materials Today Bio

影响因子:10.2

doi:10.1016/j.mtbio.2025.102738

Bu Wenxia, Jin Yueyuan, Zhou Yifan, Wang Fengxu, Zheng Dongnan, Liu Rongzhu, Wang Xuehai, Yu Mengjiao, Bao Shan, Zhao Rui, Li Jinlong, Zhou Xiaoyu, Feng Jian, Zhao Xinyuan, Cheng Demin

Circ_0008219 regulates proliferation and apoptosis in goat granulosa cells via a feedback loop with the transcription factor YY1

Circ_0008219 通过与转录因子 YY1 的反馈回路调控山羊颗粒细胞的增殖和凋亡。

期刊:BMC Genomics

影响因子:3.5

doi:10.1186/s12864-026-12552-x

Hu Tao,Fan Jiang,Nian Zhang,Yi Shuai,Hua Zhao,Juan Yang,Feng Zhang,Aishao Shangguan,Qi Xiong

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis

EP300 通过 YY1/GPX4 轴减弱铁死亡，并刺激瘢痕疙瘩成纤维细胞的增殖、迁移和纤维化。

期刊:Cell Cycle

影响因子:3.4

doi:10.1080/15384101.2026.2627885

Jin, Jun; Wang, Kai; Lu, Chenxi; Yao, Chenghao; Xie, Feng

YY1-Mediated Polycomb Group Function Safeguards Hematopoietic Stem Cells from Premature Aging

YY1介导的多梳蛋白功能保护造血干细胞免受过早衰老的影响

期刊:

影响因子:

doi:10.64898/2026.01.28.702390

Saka, Sahitya; Lee, Junki P; Wang, Yinghua; Liu, Peng; Liu, Yunxia; Hong, Courtney; Kuehnl, Ashley; Rui, Lixin; Atchison, Michael L; Pan, Xuan

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

RUNX1 和 YY1 在阿尔茨海默病中调节神经元命运和能量代谢

期刊:

影响因子:

doi:10.64898/2026.04.13.716801

Lucciola, Raffaella; Herdy, Joseph R; Vajaphattana, Yatavee; Karbacher, Lukas; Sabedot, Thais S; Cuoco, Michael S; Traxler, Larissa; Kang, Austin; Reynolds, Mack; Jones, Jeffrey R; Schafer, Simon T; Mertens, Jerome; Gage, Fred H

Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast-Myofibroblast Transition and Renal Fibrosis.

HDAC3 和辅因子 YY1 对 RASAL1 的表观遗传抑制促进成纤维细胞-肌成纤维细胞转化和肾纤维化。

期刊:Research (Wash D C)

影响因子:

doi:10.34133/research.1073

Chen Fang, Zhang Lijun, Liu Weiying, Zhang Bingbing, Wang Shuren, Zhou Zhengdong, Wang Wei, Shen Jiansong, Deng Yijun, Cao Wangsen

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice

YY1通过增强肿瘤相关巨噬细胞中HIF-1α的稳定性来抑制小鼠前列腺癌的抗肿瘤免疫反应。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-61560-0

Wenchao Li # ，SaiSai Chen # ，Jian Lu # ，Weipu Mao # ，Shiya Zheng # ，Minhao Zhang # ，Tiange Wu ，Yurui Chen ，Kai Lu ，Chunyan Chu ，Chuanjun Shu ，Yue Hou ，Xue Yang ，Naipeng Shi ，Zhijun Chen ，Lihua Zhang ，Lei Zhang ，Rong Na ，Ming Chen ，Shenghong Ju ，Dingxiao Zhang ，Yi Ma ，Bin Xu

YY1 Interacts with Promoter R-Loops to Regulate Transcription

YY1与启动子R环相互作用以调控转录

Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8(+) T-Cell-Driven Cancer Cell Pyroptosis.

靶向 Notch1-YY1-ICAM1 信号轴可激活 CD8(+) T 细胞驱动的癌细胞焦亡，从而增强免疫疗法在 HCC 中的疗效。

YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy

YY1硝化通过抑制ANXA3诱导的微脂自噬参与DbCM心肌细胞脂毒性

Polystyrene nanoplastics-induced lung epithelial cells ferroptosis promotes pulmonary fibrosis via YY1/FTL axis.

聚苯乙烯纳米塑料诱导的肺上皮细胞铁死亡通过 YY1/FTL 轴促进肺纤维化。

Circ_0008219 regulates proliferation and apoptosis in goat granulosa cells via a feedback loop with the transcription factor YY1

Circ_0008219 通过与转录因子 YY1 的反馈回路调控山羊颗粒细胞的增殖和凋亡。

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis

EP300 通过 YY1/GPX4 轴减弱铁死亡，并刺激瘢痕疙瘩成纤维细胞的增殖、迁移和纤维化。

YY1-Mediated Polycomb Group Function Safeguards Hematopoietic Stem Cells from Premature Aging

YY1介导的多梳蛋白功能保护造血干细胞免受过早衰老的影响

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

RUNX1 和 YY1 在阿尔茨海默病中调节神经元命运和能量代谢

Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast-Myofibroblast Transition and Renal Fibrosis.

HDAC3 和辅因子 YY1 对 RASAL1 的表观遗传抑制促进成纤维细胞-肌成纤维细胞转化和肾纤维化。

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice

YY1通过增强肿瘤相关巨噬细胞中HIF-1α的稳定性来抑制小鼠前列腺癌的抗肿瘤免疫反应。