日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson's disease

201试验:一项安慰剂对照的随机II期研究,旨在评估c-Abl激酶抑制剂risvodetinib在未经治疗的帕金森病患者中的安全性和耐受性

Werner, M H; McGarry, A; Meyer, C; Mancino, E; Klint, C; Pellecchia, J; Kieburtz, K; Levine, T; Bellaire, B; Gibbons, C; Freeman, R; Ellenbogen, A; Klos, K; Ospina, M; Hauser, R A; Shannon, K; Asaad, H; Park, A; McAllister, P; Isaacson, S H; LeDoux, M S; Dhall, R; Shpiner, D; Charles, P; Agarwal, P; Peckham, E; Mazzeo, P; Davis, M; Pahwa, R; Brodsky, M; Lew, M; Purino, L; Mantri, S; Parashos, S; Justiz, W; Chachar, M; Robottom, B; Budman, E; Blindauer, K; Bellows, S; Goudreau, J; Steen, S; Olanow, C W

c-Abl controls early embryonic morphogenesis through YAP/p73-dependent regulation of trophectoderm and inner cell mass lineages

c-Abl 通过 YAP/p73 依赖性调控滋养外胚层和内细胞团谱系来控制早期胚胎形态发生

Yildirim, Ecem; Onel, Tugce; Yaba, Aylin

Evaluation of c-Abl inhibitor vodobatinib in subjects with early Parkinson's disease: a phase 2, randomized, double-blind, placebo-controlled study

评估 c-Abl 抑制剂 vodobatinib 在早期帕金森病患者中的疗效:一项 2 期随机、双盲、安慰剂对照研究

Sarva, Harini; Pahwa, Rajesh; Hernandez-Vara, Jorge; Goldstein, Mark A; Borgohain, Rupam; Factor, Stewart A; Inamdar, Sandeep; Love, Damon; Hames, Carrie; Fu, Yiyong; Mergel, Victor; Goldfine, Andrew; Kumar, Chandra; Piccoli, Steven P; Yao, Siu-Long; Hurko, Orest

Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathway.

C 型凝集素受体下游的非受体酪氨酸激酶 c-Abl 通过 c-Cbl/MAPK 通路调节先天性抗真菌免疫。

Correction for Angiotensin II down-regulates nephrinAkt signaling and induces podocyte injury: role of c-Abl

血管紧张素II的校正可下调肾素-Akt信号通路并诱导足细胞损伤:c-Abl的作用

Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation

感染和除草剂暴露均表明 c-Abl 激酶参与 α-突触核蛋白 Ser129 的磷酸化。

Ehsani, Marzieh; Sun, Zeyang; Quevedo-Olmos, Alvaro; Rösler, Gesa; Rasa, Mahdi; Remes, Anca Kliesow; Hedemann, Nina; Müller, Oliver J; Erttmann, Saskia F; Holthaus, David; Meyer, Thomas F

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.

溶酶体蛋白 CLN3 的缺失会触发 c-Abl 依赖的 YAP1 促凋亡信号传导。

Domingues Neuza, Calcagni' Alessia, Freire Sofia, Pires Joana, Casqueiro Ricardo, Salazar Ivan L, Herz Niculin Joachim, Huynh Tuong, Wieciorek Katarzyna, Outeiro Tiago Fleming, Girão Henrique, Milosevic Ira, Ballabio Andrea, Raimundo Nuno

The Role of c-Abl in Alzheimer's Disease: Guilty or not Guilty?

c-Abl在阿尔茨海默病中的作用:究竟是罪魁祸首还是无辜者?

Li, Wei; Wang, Xianning; Liu, Jiannan; Chen, Yurou

c-Abl Kinase Targets Tight Junction Protein ZO-2 in Regulation of Cell Migration and Morphology.

c-Abl 激酶靶向紧密连接蛋白 ZO-2,调控细胞迁移和形态。

Choi Doo Eun, Gweon Bomi, Notbohm Jacob, Kim Heejin, Liu Xue-Song, Fredberg Jeffrey J

c-Abl Inhibitors in Parkinson's: Exploring Hypotheses on Alpha-Synuclein Modulation

帕金森病中的c-Abl抑制剂:探索α-突触核蛋白调节的假设

Nargish, Jyutia; Baishya, Hirok Jyoti; Sola, Piyong