日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells

细胞特异性模型揭示构象特异性 RAF 抑制剂组合可协同抑制胰腺癌细胞中的 ERK 信号传导

Thomas Sevrin, Hiroaki Imoto, Sarah Robertson, Nora Rauch, Uscinnia Dyn'ko, Katerina Koubova, Kieran Wynne, Walter Kolch, Oleksii S Rukhlenko, Boris N Kholodenko

Inhibition and degradation of NRAS with a pan-NRAS monobody

使用泛 NRAS 单体抑制和降解 NRAS

Michael Whaby, Gayatri Ketavarapu, Akiko Koide, Megan Mazzei, Mubashir Mintoo, Eliezra Glasser, Unnatiben Patel, Cecile Nasarre, Matthew J Sale, Frank McCormick, Shohei Koide, John P O'Bryan3

Discovery of New Quinolone-Based Diarylamides as Potent B-RAF(V600E)/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity.

发现新型喹诺酮类二芳酰胺作为强效 B-RAF(V600E)/C-RAF 激酶抑制剂,具有良好的体外抗癌活性。

Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase

C-RAF蛋白激酶介导XIAP缺失细胞的迁移和运动能力增强

Lauren G Russell ,Lydia A K Davis ,Jill E Hunter ,Neil D Perkins ,Niall S Kenneth

Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf

细粒棘球绦虫囊液中的糖分子通过 c-Raf 抑制 TLR4 介导的炎症反应。

Hou, Jun; Li, Linlin; Dong, Dan; Wang, Lianghai; Wang, Xian; Yang, Kun; Xu, Xiaodan; Chen, Congzhe; Wu, Xiangwei; Chen, Xueling

Monocyte Chemoattractant Protein-1 promotes cancer cell migration via c-Raf/MAPK/AP-1 pathway and MMP-9 production in osteosarcoma

单核细胞趋化蛋白-1通过c-Raf/MAPK/AP-1通路和MMP-9的产生促进骨肉瘤癌细胞的迁移

Liu, Ju-Fang; Chen, Po-Chun; Chang, Tsung-Ming; Hou, Chun-Han

Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD:KRas protein-protein interface

新型、可证明的算法用于高效的基于集成的计算蛋白质设计,并将其应用于c-Raf-RBD:KRas蛋白-蛋白界面的重新设计。

Lowegard, Anna U; Frenkel, Marcel S; Holt, Graham T; Jou, Jonathan D; Ojewole, Adegoke A; Donald, Bruce R

Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation

解析核c-Raf的新伙伴及其在全反式维甲酸(ATRA)诱导的髓系白血病细胞分化中的作用

Rashid, Asif; Wang, Rui; Zhang, Liang; Yue, Jianbo; Yang, Mengsu; Yen, Andrew

Correction to: Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf-MEK1-ERK signaling axis

更正:环阿屯烷三萜类化合物(23R, 24E)-23-乙酰氧基芒果酸通过抑制β-catenin和c-Raf-MEK1-ERK信号通路,进而下调MITF表达,从而抑制B16-F10黑色素瘤细胞的增殖和迁移。

Kaneda, Toshio; Matsumoto, Misaki; Sotozono, Yayoi; Fukami, Satoshi; Nugroho, Alfarius Eko; Hirasawa, Yusuke; Hamid A, Hadi A; Morita, Hiroshi

Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway

青蒿素通过激活c-Raf-Erk1/2-p90rsk-CREB通路保护大鼠骨髓间充质干细胞免受过氧化氢诱导的细胞凋亡。

Jiankang Fang ,Xia Zhao ,Shuai Li ,Xingan Xing ,Haitao Wang ,Philip Lazarovici ,Wenhua Zheng