eNOS相关文献与解析，生知库 | 链接生命科学的每一步

Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles.

利用 eNOS 激活，通过脂质纳米颗粒的内皮细胞转胞吞作用实现肿瘤血管正常化。

doi:10.1016/j.apsb.2025.11.040

Hao Huisong, Yi Yunfei, Fu Yanan, Sun Shengjie, Peng Zhangwen, Tang Jia, Fang Yixuan, Zhuang Shihao, Ouyang Yaqi, Wang Tianqi, Wu Meiying

Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis

负压机械信号通过上调HSP90表达来增加eNOS Ser1177的磷酸化，从而促进伤口血管生成。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2025.07.041

Dong, Yuchen; Zhang, Yuheng; Lin, Zhixiao; Li, Xueyong; Guo, Zheng; Li, Tian; Ma, Fuxin; Li, Jing

eNOS Uncoupling-ER Stress-Mitochondrial Dysfunction Axis in the Development of Pulmonary Hypertension.

eNOS解偶联-内质网应激-线粒体功能障碍轴在肺动脉高压发展中的作用。

期刊:Jacc-Basic To Translational Science

影响因子:7.2

doi:10.1016/j.jacbts.2026.101512

Murugesan Priya, Zhang Yunxia, Zhang Meng, Zhang Yixuan, Cai Hua

A Novel Role for the Small Molecule Cinnamaldehyde in Protecting Against P. gingivalis-Induced Endothelial Dysfunction in Mice: Involvement of PPARγ/Akt/eNOS and Nrf2/ARE Signaling

小分子肉桂醛在保护小鼠免受牙龈卟啉单胞菌诱导的内皮功能障碍中的新作用：PPARγ/Akt/eNOS 和 Nrf2/ARE 信号通路的参与

期刊:Antioxidants

影响因子:6.6

doi:10.3390/antiox15020243

Sampath, Chethan; Gaddam, Bhavyasri; Gray, Aaliyah C; Chukkapalli, Sasanka S; Gangula, Pandu R

Norisoboldine Induces Endothelium-Dependent Vasorelaxation and Attenuates Hypertension by Modulating Ca(2+)-eNOS Signaling, Oxidative Stress, and Inflammation.

诺立索勃林通过调节 Ca(2+)-eNOS 信号传导、氧化应激和炎症诱导内皮依赖性血管舒张并减轻高血压。

期刊:Antioxidants

影响因子:6.6

doi:10.3390/antiox15010131

Li Jiaze, Wang Shurui, Jin Enyi, Zhao Ziyi, Liang Jinyue, Lee Yun Jung, Cao Lihua

高血压

心血管

eNOS

Immunology/Inflammation

ALDH2 rs671 Variant Lowers Blood Pressure Via the Endothelial HSPA5-PIEZO1-eNOS Pathway

ALDH2 rs671 变异体通过内皮 HSPA5-PIEZO1-eNOS 通路降低血压

期刊:Journal of the American Heart Association

影响因子:5.3

doi:10.1161/JAHA.124.040121

Ye, Huaqing; Yue, Hongwei; Wei, Shujian; Wang, Kaiyi; Yang, Kehui; Du, Han; Sang, Wentao; Guo, Jialin; Wang, Jingwen; Guo, Yunyun; Zhang, Cheng; Cui, Sumei; Xu, Feng; Chen, Yuguo

ClC-3 mediates angiotensin II-induced endothelial dysfunction by inhibiting Akt-Hsp90-eNOS signaling pathway

ClC-3通过抑制Akt-Hsp90-eNOS信号通路介导血管紧张素II诱导的内皮功能障碍

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2026.1795707

Li, Lei; Lin, Yu-Quan; Peng, Yu-Sheng; Chen, Huan-Hao; Wu, Xiao-Jun; Liang, Guozheng; Du, Yan-Hua

Genotype-phenotype correlations in breast cancer susceptibility: evaluating MMP-2, TYMS, and eNOS variants in the Jordanian population

乳腺癌易感性的基因型-表型相关性：评估约旦人群中 MMP-2、TYMS 和 eNOS 变异体

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-34531-0

Alorjani, Mohammed; Al-Eitan, Laith; Ali, Haneen; Ghabbish, Malek

Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.

人参皂苷 Rb1 通过激活 PI3K-Akt-eNOS 通路缓解先兆子痫中的内皮功能障碍和血管重塑。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-38411-z

Jia Wen, Wang Wenli, Zhang Baolian, Wang Chengshu, Huang Xianghua

Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade

利用eNOS激活实现血管正常化，以增强PD-L1阻断的疗效

Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles.

利用 eNOS 激活，通过脂质纳米颗粒的内皮细胞转胞吞作用实现肿瘤血管正常化。

Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis

负压机械信号通过上调HSP90表达来增加eNOS Ser1177的磷酸化，从而促进伤口血管生成。

eNOS Uncoupling-ER Stress-Mitochondrial Dysfunction Axis in the Development of Pulmonary Hypertension.

eNOS解偶联-内质网应激-线粒体功能障碍轴在肺动脉高压发展中的作用。

A Novel Role for the Small Molecule Cinnamaldehyde in Protecting Against P. gingivalis-Induced Endothelial Dysfunction in Mice: Involvement of PPARγ/Akt/eNOS and Nrf2/ARE Signaling

小分子肉桂醛在保护小鼠免受牙龈卟啉单胞菌诱导的内皮功能障碍中的新作用：PPARγ/Akt/eNOS 和 Nrf2/ARE 信号通路的参与

Norisoboldine Induces Endothelium-Dependent Vasorelaxation and Attenuates Hypertension by Modulating Ca(2+)-eNOS Signaling, Oxidative Stress, and Inflammation.

诺立索勃林通过调节 Ca(2+)-eNOS 信号传导、氧化应激和炎症诱导内皮依赖性血管舒张并减轻高血压。

ALDH2 rs671 Variant Lowers Blood Pressure Via the Endothelial HSPA5-PIEZO1-eNOS Pathway

ALDH2 rs671 变异体通过内皮 HSPA5-PIEZO1-eNOS 通路降低血压

ClC-3 mediates angiotensin II-induced endothelial dysfunction by inhibiting Akt-Hsp90-eNOS signaling pathway

ClC-3通过抑制Akt-Hsp90-eNOS信号通路介导血管紧张素II诱导的内皮功能障碍

Genotype-phenotype correlations in breast cancer susceptibility: evaluating MMP-2, TYMS, and eNOS variants in the Jordanian population

乳腺癌易感性的基因型-表型相关性：评估约旦人群中 MMP-2、TYMS 和 eNOS 变异体

Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.

人参皂苷 Rb1 通过激活 PI3K-Akt-eNOS 通路缓解先兆子痫中的内皮功能障碍和血管重塑。