p16 INK4A相关文献与解析，生知库 | 链接生命科学的每一步

Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction

健康的长寿相关蛋白可改善射血分数保留的心肌病小鼠模型的心脏功能

Valeria Vincenza Alvino, Sadie Slater, Yan Qiu, Monica Cattaneo, Khaled Abdelsattar Kassem Mohammed, Seamus Gate, Vealmurugan Sekar, Annibale Alessandro Puca, Paolo Madeddu

心血管

p63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysis

通过代谢组学和基因表达分析评估 p63 在角质形成细胞衰老过程中影响不同的代谢途径

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-024-07159-7

Maria Cristina Piro, Rosalba Pecorari, Artem Smirnov, Angela Cappello, Erica Foffi, Anna Maria Lena, Yufang Shi, Gerry Melino, Eleonora Candi

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

抗衰老药物 ABT263 通过选择性清除衰老骨骼细胞，改善因活性维生素 D 不足引起的骨质疏松症

期刊:Journal of Orthopaedic Translation

影响因子:5.9

doi:10.1016/j.jot.2024.08.012

Cuicui Yang, Wanxin Qiao, Qi Xue, David Goltzman, Dengshun Miao, Zhan Dong

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts

增强细胞稳态：靶向植物化合物增强正常和过早衰老成纤维细胞的细胞健康功能

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom14101310

Ramona Hartinger, Khushboo Singh, Jesse Leverett, Karima Djabali

Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes

糖尿病引起的血管老化过程中，异常的STING激活通过抑制自噬促进巨噬细胞衰老。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2024.111594

Huiqing Ding ,Quan Zhang ,Rukai Yang ,Liyao Fu ,Hejun Jiang ,Qingyi Zhu ,Shi Tai

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway

α-松油醇通过端粒酶非依赖性途径诱导 Shelterin 成分 TRF1 和 TRF2 缓解衰老和端粒完整性丧失

期刊:Antioxidants

影响因子:

doi:10.3390/antiox13101258

Marianna Kapetanou, Sophia Athanasopoulou, Andreas Goutas, Dimitra Makatsori, Varvara Trachana, Efstathios Gonos

p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling

p16 INK4A 通过胆汁 E2F1/FOXO1/IGF-1 信号通路驱动高脂饮食喂养小鼠的非酒精性脂肪肝疾病表型

期刊:Hepatology

影响因子:15.8

doi:10.1097/HEP.0000000000000307

Kundu, Debjyoti; Kennedy, Lindsey; Zhou, Tianhao; Ekser, Burcin; Meadows, Vik; Sybenga, Amelia; Kyritsi, Konstantina; Chen, Lixian; Ceci, Ludovica; Wu, Nan; Wu, Chaodong; Glaser, Shannon; Carpino, Guido; Onori, Paolo; Gaudio, Eugenio; Alpini, Gianfranco; Francis, Heather

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation

苦参水提取物通过诱导人宫颈癌细胞凋亡，涉及p16 INK4A的重新表达，而p16 INK4A的重新表达与UHRF1和DNMT1的下调有关。

期刊:Journal of Experimental & Clinical Cancer Research

影响因子:12.8

doi:10.1186/1756-9966-32-30

Krifa, Mounira; Alhosin, Mahmoud; Muller, Christian D; Gies, Jean-Pierre; Chekir-Ghedira, Leila; Ghedira, Kamel; Mély, Yves; Bronner, Christian; Mousli, Marc

Biological functions of extracellular vesicle double C2-like domain beta in cervical cancer

细胞外囊泡双C2样结构域β在宫颈癌中的生物学功能

Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence

IRTKS 凝聚物形成和重塑异染色质可抵消细胞衰老

Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction

健康的长寿相关蛋白可改善射血分数保留的心肌病小鼠模型的心脏功能

p63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysis

通过代谢组学和基因表达分析评估 p63 在角质形成细胞衰老过程中影响不同的代谢途径

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

抗衰老药物 ABT263 通过选择性清除衰老骨骼细胞，改善因活性维生素 D 不足引起的骨质疏松症

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts

增强细胞稳态：靶向植物化合物增强正常和过早衰老成纤维细胞的细胞健康功能

Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes

糖尿病引起的血管老化过程中，异常的STING激活通过抑制自噬促进巨噬细胞衰老。

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway

α-松油醇通过端粒酶非依赖性途径诱导 Shelterin 成分 TRF1 和 TRF2 缓解衰老和端粒完整性丧失

p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling

p16 INK4A 通过胆汁 E2F1/FOXO1/IGF-1 信号通路驱动高脂饮食喂养小鼠的非酒精性脂肪肝疾病表型

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation

苦参水提取物通过诱导人宫颈癌细胞凋亡，涉及p16 INK4A的重新表达，而p16 INK4A的重新表达与UHRF1和DNMT1的下调有关。