日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

脂质口袋结合物引起蛋白激酶p38α活性位点周围蛋白质动力学的变构变化

Medina Gómez, Sara; Homberg, Laurin T; Bührmann, Mike; Rauh, Daniel; Linser, Rasmus

Small Gold Nanoparticles Alleviate Huntington's Disease via Modulating p38α Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1

小金纳米颗粒通过调节p38α丝裂原活化蛋白激酶和丙酮酸脱氢酶激酶1缓解亨廷顿病

Lee, Leo Kit Cheung; Leong, Lok I; Shyngys, Moldir; Bai, Qianqian; Lui, Ying Lam; Cui, Can; Liu, Shaorui; Xiao, Yu; Chan, Cecilia Ka Wing; Cheung, Wing-Hoi; Kwan, Kin Ming; Chan, Ho Yin Edwin; Choi, Chung Hang Jonathan

Inhibition of MAPK p38α overcomes the cancer immunosurveillance defect caused by FPR1 loss-of-function mutation.

抑制 MAPK p38α 可克服 FPR1 功能丧失突变引起的癌症免疫监视缺陷。

p38α MAPK-Mediated Redox Regulation of Transglutaminase 2 Drives Microvascular Leakage in Diabetic Retinas

p38α MAPK介导的转谷氨酰胺酶2氧化还原调控驱动糖尿病视网膜微血管渗漏

Koh, Tae-Yong; Lee, Ah-Jun; Moon, Chan-Hee; Cho, Woo Ri; Yoon, Ji-Seok; Kim, Minsoo; Ha, Kwon-Soo

Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.

表儿茶素没食子酸酯通过抑制 p38α 介导的自噬和氧化应激来改善 UVB 诱导的光老化。

Yang Danni, Sun Ru, Cui Yulin, Li Yuqi, Hou Huixin, Otsuki Kouharu, Li Wei, Xu Jian, Zhang Peipei, Zhang Jie

SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38α.

AgRP 神经元中 SHANK3 的缺乏通过激活 p38α 抑制饮食诱导的肥胖。

Wu Shanshan, Liang Yixiao, Xu Yang, Ge Yueping, Wang Jing, Wang Lu, Jin Xinchen, Zhan Huidong, Peng Li, Gao Ling, Zhao Jiajun, He Zhao

Akkermansia muciniphila alleviates antibiotic- and LPS-induced oxidative stress via the p38α MAPK-Nrf2 signaling axis

阿克曼菌(Akkermansia muciniphila)通过 p38α MAPK-Nrf2 信号通路减轻抗生素和脂多糖(LPS)诱导的氧化应激。

Ye, Wen-Yu; Feng, Cai-Xia; Su, Shi-Qi; Wei, Su-Mei; Mao, Ying; Chen, Zhen-Yu; Su, Ying; Shan, Qing-Wen

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

靶向治疗癌症中的p38α:挑战、机遇和新兴策略

Nebreda, Angel R

SLC39A10 drives M2 macrophage polarization and gastric cancer progression through the MAPK14(p38α) pathway

SLC39A10 通过 MAPK14(p38α) 通路驱动 M2 巨噬细胞极化和胃癌进展。

Liang, Yinhua; Li, Mengting; Zhang, Chihao; Pan, Chunpeng; Wang, Shoulian; Xu, Xin; Yu, Jiwei

Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers.

骨骼肌中 p38α 的慢性激活会导致坏死性变化,但也会消除 MK2、MK3 和 MKK6 的表达,肌肉可以恢复。

Gilad Nechama, Darlyuk-Saadon Ilona, Mohanam Manju Payini, Engelberg David