日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity

DNMT3A在造血干细胞中的非经典功能调节端粒酶活性和基因组完整性

Infencia Xavier Raj ,Won Kyun Koh ,Jessica Harrison ,Christine R Zhang ,Barbara Soares ,Roberta Amato ,Aishwarya Krishnan ,David R O'Leary ,Hassan Bjeije ,Tyler M Parsons ,Wentao Han ,Andrew L Young ,Ting Wang ,Luis F Z Batista ,Grant A Challen

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis

线粒体膜电位升高是Dnmt3a突变克隆性造血的治疗靶点。

Kira A Young,Mohsen Hosseini,Jayna J Mistry,Claudia Morganti,Taylor S Mills,Xiurong Cai,Brandon T James,Griffin J Nye,Natalie R Fournier,Veronique Voisin,Ali Chegini,Aaron D Schimmer,Gary D Bader,Grace Egan,Marc R Mansour,Grant A Challen,Eric M Pietras,Kelsey H Fisher-Wellman,Keisuke Ito,Steven M Chan,Jennifer J Trowbridge

Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early-life DNMT3A mutations

移植后携带产前和早期DNMT3A突变的造血干细胞的克隆动态

Lucca L M Derks ,Konradin F Müskens ,Markus J van Roosmalen ,Aniek O de Graaf ,Nina Epskamp ,Laurianne Trabut ,Rico Hagelaar ,Joop H Jansen ,Caroline A Lindemans ,Maaike G J M van Bergen ,Ruben van Boxtel ,Mirjam E Belderbos

Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation

转录组变化(包括p53失调)使DNMT3A突变细胞更容易发生转化。

Erin M Lawrence # ,Amali Cooray # ,Andrew J Kueh ,Martin Pal ,Lin Tai ,Alexandra L Garnham ,Connie S N Li-Wai-Suen ,Hannah Vanyai ,Quentin Gouil ,James Lancaster ,Sylvie Callegari ,Lauren Whelan ,Elizabeth Lieschke ,Annabella Thomas ,Andreas Strasser ,Yang Liao ,Wei Shi ,Andrew H Wei ,Marco J Herold

Mutated DNMT3A creates a public HLADQ- binding neoantigen on acute myeloid leukemia

突变的DNMT3A在急性髓系白血病上产生一种公共的HLADQ结合新抗原。

Dyantha I van der Lee ,Eva M Argiro ,Sebastiaan N J Laan ,M Willy Honders ,Rob C M de Jong ,Nadine E Struckman ,J H Frederik Falkenburg ,Marieke Griffioen

Dnmt3a overexpression disrupts skeletal muscle homeostasis, promotes an aging-like phenotype, and reduces metabolic elasticity

Dnmt3a 过表达会破坏骨骼肌稳态,促进衰老样表型,并降低代谢弹性。

Mamoru Oyabu ,Yuto Ohira ,Mariko Fujita ,Kiyoshi Yoshioka ,Runa Kawaguchi ,Atsushi Kubo ,Yukino Hatazawa ,Hinako Yukitoshi ,Huascar Pedro Ortuste Quiroga ,Naoki Horii ,Fumihito Miura ,Hiromitsu Araki ,Masaki Okano ,Izuho Hatada ,Hitoshi Gotoh ,Tatsuya Yoshizawa ,So-Ichiro Fukada ,Yoshihiro Ogawa ,Takashi Ito ,Kengo Ishihara ,Yusuke Ono ,Yasutomi Kamei

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

由DNMT3A突变驱动的克隆性造血促进炎症性骨丢失

Hui Wang ,Kimon Divaris ,Bohu Pan ,Xiaofei Li ,Jong-Hyung Lim ,Gundappa Saha ,Marko Barovic ,Danai Giannakou ,Jonathan M Korostoff ,Yu Bing ,Souvik Sen ,Kevin Moss ,Di Wu ,James D Beck ,Christie M Ballantyne ,Pradeep Natarajan ,Kari E North ,Mihai G Netea ,Triantafyllos Chavakis ,George Hajishengallis

Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations

结构导向的AML相关DNMT3A热点突变的功能抑制

Jiuwei Lu # ,Yiran Guo # ,Jiekai Yin ,Jianbin Chen ,Yinsheng Wang ,Gang Greg Wang ,Jikui Song

Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

癌症相关的多梳蛋白靶点DNA高甲基化需要DNMT3A双重识别组蛋白H2AK119泛素化和核小体酸性斑块。

Kristjan H Gretarsson ,Stephen Abini-Agbomson ,Susan L Gloor ,Daniel N Weinberg ,Jamie L McCuiston ,Vishnu Udayakumar Sunitha Kumary ,Allison R Hickman ,Varun Sahu ,Rachel Lee ,Xinjing Xu ,Natalie Lipieta ,Samuel Flashner ,Oluwatobi A Adeleke ,Irina K Popova ,Hailey F Taylor ,Kelsey Noll ,Carolina Lin Windham ,Danielle N Maryanski ,Bryan J Venters ,Hiroshi Nakagawa ,Michael-Christopher Keogh ,Karim-Jean Armache ,Chao Lu