日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants

多组学QTL定位揭示了GWAS位点的表型复杂性,并优先考虑了假定的致病变异。

Timothy D Arthur ,Jennifer P Nguyen ,Benjamin A Henson ,Agnieszka D'Antonio-Chronowska ,Jeffrey Jaureguy ,Nayara Silva ,Juan Carlos Izpisua Belmonte ,Matteo D'Antonio ,Graham McVicker ,Kelly A Frazer

The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses

肌动蛋白成核促进因子WASH促进人乳头瘤病毒的非网格蛋白依赖性内吞作用

Pia Brinkert ,Lena Krebs ,Pilar Samperio Ventayol ,Lilo Greune ,Carina Bannach ,Cynthia Amakiri ,Delia Bucher ,Jana Kollasser ,Petra Dersch ,Steeve Boulant ,Theresia E B Stradal ,Mario Schelhaas

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens

通过汇总单细胞 CRISPR 筛选发现 GWAS 位点的靶基因和通路

John A Morris ,Christina Caragine ,Zharko Daniloski ,Júlia Domingo ,Timothy Barry ,Lu Lu ,Kyrie Davis ,Marcello Ziosi ,Dafni A Glinos ,Stephanie Hao ,Eleni P Mimitou ,Peter Smibert ,Kathryn Roeder ,Eugene Katsevich ,Tuuli Lappalainen ,Neville E Sanjana

Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins

皮质肌动蛋白和WASP家族蛋白协同激活Arp2/3复合物的机制

Fred E Fregoso ,Malgorzata Boczkowska ,Grzegorz Rebowski ,Peter J Carman ,Trevor van Eeuwen ,Roberto Dominguez

The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells

COPD GWAS基因ADGRG6指导人iPSC衍生II型肺泡上皮细胞的功能和损伤反应

Rhiannon B Werder ,Kayleigh A Berthiaume ,Carly Merritt ,Marissa Gallagher ,Carlos Villacorta-Martin ,Feiya Wang ,Pushpinder Bawa ,Vidhi Malik ,Shawn M Lyons ,Maria C Basil ,Edward E Morrisey ,Darrell N Kotton ,Xiaobo Zhou ,Michael H Cho ,Andrew A Wilson

Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation

WASH缺陷型中性粒细胞中颗粒亚群的差异性失调导致炎症

Jennifer L Johnson # ,Elsa Meneses-Salas # ,Mahalakshmi Ramadass # ,Jlenia Monfregola ,Farhana Rahman ,Raquel Carvalho Gontijo ,William B Kiosses ,Kersi Pestonjamasp ,Dale Allen ,Jinzhong Zhang ,Douglas G Osborne ,Yanfang Peipei Zhu ,Nathan Wineinger ,Kasra Askari ,Danni Chen ,Juan Yu ,Scott C Henderson ,Catherine C Hedrick ,Matilde Valeria Ursini ,Sergio Grinstein ,Daniel D Billadeau ,Sergio D Catz

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells

利用 CRISPR 干扰技术对 COPD GWAS 基因进行分析,揭示了桥粒蛋白在 iPSC 衍生肺泡上皮细胞中的功能意义

Rhiannon B Werder ,Tao Liu ,Kristine M Abo ,Jonathan Lindstrom-Vautrin ,Carlos Villacorta-Martin ,Jessie Huang ,Anne Hinds ,Nathan Boyer ,Esther Bullitt ,Marc Liesa ,Edwin K Silverman ,Darrell N Kotton ,Michael H Cho ,Xiaobo Zhou ,Andrew A Wilson

WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues

WASp触发机械敏感性肌动蛋白斑块,促进致密组织中的免疫细胞迁移。

Florian Gaertner ,Patricia Reis-Rodrigues ,Ingrid de Vries ,Miroslav Hons ,Juan Aguilera ,Michael Riedl ,Alexander Leithner ,Saren Tasciyan ,Aglaja Kopf ,Jack Merrin ,Vanessa Zheden ,Walter Anton Kaufmann ,Robert Hauschild ,Michael Sixt

Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types

利用启动子靶向捕获技术(Capture-C)在疾病相关免疫细胞类型中鉴定 COVID-19 GWAS 位点的效应基因

Matthew C Pahl ,Carole Le Coz ,Chun Su ,Prabhat Sharma ,Rajan M Thomas ,James A Pippin ,Emylette Cruz Cabrera ,Matthew E Johnson ,Michelle E Leonard ,Sumei Lu ,Alessandra Chesi ,Kathleen E Sullivan ,Neil Romberg ,Struan F A Grant # ,Andrew D Wells #

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

精神分裂症全基因组关联研究(GWAS)位点的影响在发育过程中汇聚于皮层中间神经元和谷氨酸能神经元的不同通路。

Dongxin Liu ,Amy Zinski ,Akanksha Mishra ,Haneul Noh ,Gun-Hoo Park ,Yiren Qin ,Oshoname Olorife ,James M Park ,Chiderah P Abani ,Joy S Park ,Janice Fung ,Farah Sawaqed ,Joseph T Coyle ,Eli Stahl ,Jaroslav Bendl ,John F Fullard ,Panos Roussos ,Xiaolei Zhang ,Patric K Stanton ,Changhong Yin ,Weihua Huang ,Hae-Young Kim ,Hyejung Won ,Jun-Hyeong Cho ,Sangmi Chung