日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Akap11突变小鼠(一种精神分裂症和双相情感障碍的遗传模型)中突触PKA活性升高和纹状体多巴胺信号异常

Bryan J Song # ,Yang Ge # ,Ally Nicolella ,Min Jee Kwon ,Bart Lodder ,Kevin Bonanno ,Antia Valle-Tojeiro ,Nolan D Hartley ,Kira Perzel Mandell ,John Adeleye ,Deeksha Misri ,Chuhan Geng ,Sahana Natarajan ,Inès Picard ,Nate Shepard ,Alyssa Hall ,Jiawen Tian ,Sameer Aryal ,Zohreh Farsi ,Xiao-Man Liu ,Nader Morshed ,Naeem M Nadaf ,Horia Pribiag ,Sean K Simmons ,D R Mani ,Beth Stevens ,Prabhat S Kunwar ,Zhanyan Fu ,Evan Z Macosko ,Joshua Z Levin ,Bernardo L Sabatini ,Steven A Carr ,Borislav Dejanovic ,Hasmik Keshishian ,Adam J Granger ,Morgan Sheng

Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling

自噬体锚定一个依赖于 AKAP11 的调控检查点,该检查点塑造神经元 PKA 信号传导。

Ashley Segura-Roman #,Y Rose Citron #,Myungsun Shin,Nicole Sindoni,Alex Maya-Romero,Simon Rapp,Claire Goul,Joseph D Mancias,Roberto Zoncu

Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes

锂可以部分挽救因AKAP11杂合敲除而导致的基因表达和增强子活性受损,同时诱导新的差异性变化。

Nargess Farhangdoost ,Alessia Pietrantonio ,Yumin Liu ,Calwing Liao ,Daniel Rochefort ,Alain Pacis ,Martin Alda ,Patrick A Dion ,Boris Chaumette ,Anouar Khayachi ,Guy A Rouleau

AKAP12 positive fibroblast determines immunosuppressive contexture and immunotherapy response in patients with TNBC by promoting macrophage M2 polarization

AKAP12阳性成纤维细胞通过促进巨噬细胞M2极化,决定TNBC患者的免疫抑制环境和免疫治疗反应。

Zhenkun Liu #,Siyuan Hu #,Xinlei Zhao #,Wenxin Xu,Feng Ju,Meiying Gu,Jialei Weng,Yabing Du

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

AKAP1的缺失会引发Drp1去磷酸化介导的线粒体分裂,并导致视网膜神经节细胞丢失。

Genea Edwards # ,Guy A Perkins # ,Keun-Young Kim # ,YeEun Kong ,Yonghoon Lee ,Soo-Ho Choi ,Yujia Liu ,Dorota Skowronska-Krawczyk ,Robert N Weinreb ,Linda Zangwill ,Stefan Strack ,Won-Kyu Ju

AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP

AKAP150棕榈酰化调控钙离子通透性AMPA受体在突触中的整合,从而控制长时程增强作用(LTP)。

Alicia M Purkey ,Kevin M Woolfrey ,Kevin C Crosby ,Dominik G Stich ,Wallace S Chick ,Jason Aoto ,Mark L Dell'Acqua