CAS9相关文献与解析，生知库 | 链接生命科学的每一步

Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease.

利用 CRISPR/Cas9 技术精确切除 NOTCH2NLC 中扩增的 GGC 重复序列，用于治疗神经元核内包涵体病。

Xie Nina, Pan Yongcheng, Tong Huichun, Lin Yingqi, Jiang Ying, Wang Zhiqin, Wan Juan, Zhang Wendiao, Wang Xinhui, Sun Xiaobo, Yan Sen, Yin Peng, Sun Qiying, Qi Chengzhi, Tian Yun, Shen Lu, Jiang Hong, Liang Desheng, Tang Beisha, Li Shihua, Li Xiao-Jiang, Liu Qiong

神经科学

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas.

定量蛋白质组学和 CRISPR/Cas9 编辑揭示了 UPR 介导的杂交瘤免疫球蛋白稳态控制。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202514140

Zou Rubing, Lu Xinying, Liu Ying, Yang Peiyu, Sun Shuo, Liu Yihua, Mo Yinyuan, Zhu Guonian, Lee Jae Seong, Guo Yirong

CRISPR/Cas9-mediated t(4;11) translocation in human hematopoietic stem/precursor cells demonstrates plasticity to differentiate into either the myeloid or lymphoid lineage.

人类造血干/前体细胞中 CRISPR/Cas9 介导的 t(4;11) 易位表现出可塑性，能够分化为髓系或淋巴系。

期刊:Leukemia

影响因子:13.4

doi:10.1038/s41375-025-02791-4

eVLP-Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

利用eVLP介导的Cas9递送预防胰岛移植中的IBMIR

期刊:Small

影响因子:13

doi:10.1002/smll.202508128.

Manju Shrestha,Yeonji Kim,Subin Park,Hu-Lin Jiang,Jae-Young Lee,Daesik Kim,Jee-Heon Jeong

CAS9

发表日期：2026

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Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility.

利用一种 Cas9 变体以超高保真度和广泛兼容性靶向转甲状腺素蛋白。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adu6505

CAS9

发表日期：2026

文献求助收藏

FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing.

FAST-CRISPR：利用脂质-二氧化硅混合纳米颗粒实现 CRISPR/Cas9 核糖核蛋白的融合结合和安全转染，用于治疗性基因组编辑。

期刊:Small

影响因子:12.1

doi:10.1002/smll.202511362

Kim Minjong, Kim Kyunghwan, Lee Jihyun, Lee Soyoung, Choi Subin, Park Soo Ah, Jeong Euihwan, Choi Song-Yi, Park Hee Ho, Park Tae-Eun, Kwon Taejoon, Myung Kyungjae, Yoo Jounghyun, Cho Seung Woo, Joo Jinmyoung

Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects.

对 CRISPR/dCas9 表观基因组编辑器的全面分析表明，靶向效应和脱靶效应之间存在复杂的联系。

期刊:Genome Biology

影响因子:9.4

doi:10.1186/s13059-026-03967-6

Pahlevan Kakhki Majid, Rangani Fatemeh, Ewing Ewoud, Starvaggi Cucuzza Chiara, Zheleznyakova Galina, Kalomoiri Maria, Kenny Lea, Raghavan Anika, Rao Prakash Chandana, van den Hoeven Gabe, Venkata S Badam Tejaswi, Covacu Ruxandra, Andreou Ioanna, Needhamsen Maria, Kular Lara, Jagodic Maja

CAS9

发表日期：2026

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Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.

基于 CRISPR/dCas9 系统的 BRD7 启动子靶向去甲基化可抑制鼻咽癌的恶性进展。

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.70583

Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism.

利用 4-OHT 诱导的 Cas9 在全生物体中进行阶段和组织特异性基因编辑。

期刊:Journal of Cell Biology

影响因子:6.4

doi:10.1083/jcb.202412216

Li Yaqi, Zhang Weiying, Wei Zihang, Li Han, Liu Xin, Zheng Tao, Aziz Tursunjan, Xing Cencan, Meng Anming, Wu Xiaotong

CAS9

发表日期：2026

文献求助收藏

Optimized CRISPR-Cas9 system for efficient engineering of ecDNA in cancer cells

优化的 CRISPR-Cas9 系统可高效地对癌细胞中的 ecDNA 进行编辑

Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease.

利用 CRISPR/Cas9 技术精确切除 NOTCH2NLC 中扩增的 GGC 重复序列，用于治疗神经元核内包涵体病。

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas.

定量蛋白质组学和 CRISPR/Cas9 编辑揭示了 UPR 介导的杂交瘤免疫球蛋白稳态控制。

CRISPR/Cas9-mediated t(4;11) translocation in human hematopoietic stem/precursor cells demonstrates plasticity to differentiate into either the myeloid or lymphoid lineage.

人类造血干/前体细胞中 CRISPR/Cas9 介导的 t(4;11) 易位表现出可塑性，能够分化为髓系或淋巴系。

eVLP-Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

利用eVLP介导的Cas9递送预防胰岛移植中的IBMIR

Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility.

利用一种 Cas9 变体以超高保真度和广泛兼容性靶向转甲状腺素蛋白。

FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing.

FAST-CRISPR：利用脂质-二氧化硅混合纳米颗粒实现 CRISPR/Cas9 核糖核蛋白的融合结合和安全转染，用于治疗性基因组编辑。

Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects.

对 CRISPR/dCas9 表观基因组编辑器的全面分析表明，靶向效应和脱靶效应之间存在复杂的联系。

Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.

基于 CRISPR/dCas9 系统的 BRD7 启动子靶向去甲基化可抑制鼻咽癌的恶性进展。

Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism.

利用 4-OHT 诱导的 Cas9 在全生物体中进行阶段和组织特异性基因编辑。