日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease

单等位基因 TYROBP 缺失是阿尔茨海默病的一个新的风险因素

Henna Martiskainen # ,Roosa-Maria Willman # ,Päivi Harju ,Sami Heikkinen ,Mette Heiskanen ,Stephan A Müller ,Rosa Sinisalo ,Mari Takalo ,Petra Mäkinen ,Teemu Kuulasmaa ,Viivi Pekkala ,Ana Galván Del Rey ,Sini-Pauliina Juopperi ,Heli Jeskanen ,Inka Kervinen ,Kirsi Saastamoinen ,Sami V Heikkinen ,Mitja I Kurki ,Jarkko Marttila ,Petri I Mäkinen ,Hannah Rostalski ,Tomi Hietanen ,Tiia Ngandu ,Jenni Lehtisalo ,Céline Bellenguez ,Jean-Charles Lambert ,Christian Haass ,Juha Rinne ,Juhana Hakumäki ,Tuomas Rauramaa ,Johanna Krüger ,Hilkka Soininen ,Annakaisa Haapasalo ,Stefan F Lichtenthaler ,Ville Leinonen ,Eino Solje ,Mikko Hiltunen

TEAD3 + high-risk melanoma cells crosstalk with GAS6 + macrophages via the GAS6-TYRO3 ligand-receptor axis to modulate propionate metabolism and drive melanoma progression

TEAD3+高危黑色素瘤细胞通过GAS6-TYRO3配体-受体轴与GAS6+巨噬细胞相互作用,从而调节丙酸代谢并驱动黑色素瘤进展。

Yongjin Fang ,Xiaofan Xu # ,Rihui Lu # ,Ye Huang # ,Xinshen Dai # ,Pucheng Huang # ,Xuefeng Fu # ,Pan Zhuge #

UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor

UNC9426,一种强效且口服生物利用度高的TYRO3特异性抑制剂

Deyu Kong ,Xiangbo Yang ,Samantha Judd ,Dan Yan ,Stephanie Springborn ,Michael A Stashko ,Adam Kidwell ,Justus M Huelse ,Dmitri Kireev ,Douglas K Graham ,Deborah DeRyckere ,Brian Branchford ,Xiaodong Wang

Discovery of Novel TYRO3/MERTK Dual Inhibitors

新型TYRO3/MERTK双重抑制剂的发现

Deyu Kong ,Jichen Zhao ,Daowei Huang ,Michael A Stashko ,Dan Yan ,Ransheng Ding ,Shiva K R Guduru ,Yubai Zhou ,Catherine E Kania ,H Shelton Earp 3rd ,Stephen V Frye ,Justus M Huelse ,Dmitri Kireev ,Deborah DeRyckere ,Douglas K Graham ,Xiaodong Wang

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes

靶向TYRP1表面表达的CAR-T细胞疗法用于治疗皮肤黑色素瘤和罕见黑色素瘤亚型

Sameeha Jilani # ,Justin D Saco # ,Edurne Mugarza # ,Aleida Pujol-Morcillo ,Jeffrey Chokry ,Clement Ng ,Gabriel Abril-Rodriguez ,David Berger-Manerio ,Ami Pant ,Jane Hu ,Rubi Gupta ,Agustin Vega-Crespo ,Ignacio Baselga-Carretero ,Jia M Chen ,Daniel Sanghoon Shin ,Philip Scumpia ,Roxana A Radu ,Yvonne Chen ,Antoni Ribas ,Cristina Puig-Saus

The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg

丁酸球菌(Butyricicoccus pullicaecorum)与3-羟基邻氨基苯甲酸的组合可通过调节肠道菌群和Th17/Treg细胞来预防绝经后骨质疏松症。

Fuping Zhu # ,Hui Liu # ,Yinsheng Cao ,Bing Dai ,Hang Wu ,Wuping Li

TYRO3 agonist as therapy for glomerular disease

TYRO3激动剂作为肾小球疾病的治疗方法

Fang Zhong ,Hong Cai ,Jia Fu ,Zeguo Sun ,Zhengzhe Li ,David Bauman ,Lois Wang ,Bhaskar Das ,Kyung Lee ,John Cijiang He

Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats

STAT3在Tyr705位点的磷酸化导致TFEB介导的自噬-溶酶体通路功能障碍,进而引起大鼠缺血性损伤。

Yueyang Liu ,Xiaohang Che ,Xiangnan Yu ,Hanxiao Shang ,Peirui Cui ,Xiaoxiao Fu ,Xianda Lu ,Yuhuan Liu ,Chunfu Wu ,Jingyu Yang

Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation

探索Tyr-82位点共价键形成对Ral GTPase活化的抑制作用

Alexander D Landgraf ,I-Ju Yeh ,Mona K Ghozayel ,Khuchtumur Bum-Erdene ,Giovanni Gonzalez-Gutierrez ,Samy O Meroueh

TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

TYRO3通过限制先天免疫和肿瘤铁死亡诱导抗PD-1/PD-L1疗法耐药。

Zhou Jiang ,Seung-Oe Lim ,Meisi Yan ,Jennifer L Hsu ,Jun Yao ,Yongkun Wei ,Shih-Shin Chang ,Hirohito Yamaguchi ,Heng-Huan Lee ,Baozhen Ke ,Jung-Mao Hsu ,Li-Chuan Chan ,Gabriel N Hortobagyi ,Liuqing Yang ,Chunru Lin ,Dihua Yu ,Mien-Chie Hung